Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: Two Extra Heteroatoms 1:1

Regan, Andrew C.; Katritzky, Alan R.; Ramsden, Christopher A.; Scriven, E. F. V.; Taylor, Richard J. K.

doi:10.1016/b978-008044992-0.01012-9

Cited by 4 publications

(8 citation statements)

References 309 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pyrazoles can act as weak bases or acids, with possible strength highly dependent on the nature of their substituent groups. The other three positions in the ring permit structural variants starting from the appropriate precursors or using post-functionalization reactions once the pyrazole ring is formed [1][2][3][4][5]; these variations give the pyrazoles diverse and valuable synthetical, biological, and photophysical properties; indeed, more complex structures with various relevant examples can be formed from them (Figure 1) [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Some fused pyrazoles also have demonstrated different biological activities, exceptional photophysical properties, and high synthetical versatility that allow the obtention of industrially and pharmaceutically crucial chemicals [1][2][3][4][5][6][7][8][9]; thus, synthesizing pyrazole derivatives efficiently and selectively is an important area of organic chemistry. For instance, pyrazoles have biological activities in many specific areas, such as anticancer, antibacterial, antifungal, antioxidant, and anti-inflammatory, among others [1,8].…”

Section: Introductionmentioning

confidence: 99%

“…The other three positions in the ring permit structural variants starting from the appropriate precursors or using post-functionalization reactions once the pyrazole ring is formed [1][2][3][4][5]; these variations give the pyrazoles diverse and valuable synthetical, biological, and photophysical properties; indeed, more complex structures with various relevant examples can be formed from them (Figure 1) [1][2][3][4][5][6][7][8][9]. Some fused pyrazoles also have demonstrated different biological activities, exceptional photophysical properties, and high synthetical versatility that allow the obtention of industrially and pharmaceutically crucial chemicals [1][2][3][4][5][6][7][8][9]; thus, synthesizing pyrazole derivatives efficiently and selectively is an important area of organic chemistry. For in-ortilla, J. stance, pyrazoles have biological activities in many specific areas, such as anticancer, antibacterial, antifungal, antioxidant, and anti-inflammatory, among others [1,8].…”

Section: Introductionmentioning

confidence: 99%

“…The chemistry of pyrazole derivatives has been extensively documented for several years due to their synthetic versatility and applicability in diverse fields [1][2][3][4][5][6][7]22,23]. Despite rings with oxygen or sulfur atoms being part of some fused pyrazole derivatives, nitrogenous rings predominate in heteroaromatic structures (Figure 1b).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recent Advances in Synthesis and Properties of Pyrazoles

Ríos

Portilla

2022

Chemistry

View full text Add to dashboard Cite

Pyrazole-containing compounds represent one of the most influential families of N-heterocycles due to their proven applicability and versatility as synthetic intermediates in preparing relevant chemicals in biological, physical-chemical, material science, and industrial fields. Therefore, synthesizing structurally diverse pyrazole derivatives is highly desirable, and various researchers continue to focus on preparing this functional scaffold and finding new and improved applications; this review highlights some of the most recent and strategic examples regarding the synthesis and properties of different pyrazole derivatives, mainly reported from 2017–present. The discussion involves strategically functionalized rings (i.e., amines, carbaldehydes, halides, etc.) and their use in forming various fused systems, predominantly bicyclic cores with 5:6 fusion taking advantage of our experience in this field and the more recent investigations of our research group.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances in Synthesis and Properties of Pyrazoles

Ríos

Portilla

2022

Chemistry

View full text Add to dashboard Cite

show abstract

“…Regardless, innovative synthesis methods still emerge that offer creative ways to modify established ones. Notably, the main synthesis route of pyrazolo[1,5-a]pyrimidines allows versatile structural modifications at positions 2, 3, 5, 6, and 7 via the cyclocondensation reaction of 1,3-biselectrophilic compounds with NH-3-aminopyrazoles as 1,3-bisnucleophilic systems ( Figure 1 b) [ 1 , 2 , 3 , 4 , 5 , 6 , 24 , 25 ].…”

Section: Synthesis and Functionalizationmentioning

confidence: 99%

Functional Pyrazolo[1,5-a]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

2021

View full text Add to dashboard Cite

Pyrazolo[1,5-a]pyrimidine (PP) derivatives are an enormous family of N-heterocyclic compounds that possess a high impact in medicinal chemistry and have attracted a great deal of attention in material science recently due to their significant photophysical properties. Consequently, various researchers have developed different synthesis pathways for the preparation and post-functionalization of this functional scaffold. These transformations improve the structural diversity and allow a synergic effect between new synthetic routes and the possible applications of these compounds. This contribution focuses on an overview of the current advances (2015–2021) in the synthesis and functionalization of diverse pyrazolo[1,5-a]pyrimidines. Moreover, the discussion highlights their anticancer potential and enzymatic inhibitory activity, which hopefully could lead to new rational and efficient designs of drugs bearing the pyrazolo[1,5-a]pyrimidine core.

show abstract

Microwave Radiations: A Green Approach to the Synthesis of Five- Membered Heterocyclic Compounds

Kamboj

Bajpai

Yadav

et al. 2023

CGC

View full text Add to dashboard Cite

Synthesis of heterocyclic scaffolds by microwave irradiation is a green and clean process. The organic transformation induced by microwave irradiation, as an alternative source of energy, has been of great interest due to the high efficiency, yield, and short reaction time with minimum by-product production. Heterocyclic compounds, an important skeleton for pharmaceuticals, are the most privileged and prevalent class of organic chemistry. They have enormous medicinal value and pharmaceutical potential. This review demonstrates the effectiveness of microwave heating for the synthesis of heterocyclic compounds. The eco-friendly microwave-induced synthesis of five-membered heterocyclic systems covering recent literature is highlighted in this article.

show abstract

Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: Two Extra Heteroatoms 1:1

Cited by 4 publications

References 309 publications

Recent Advances in Synthesis and Properties of Pyrazoles

Recent Advances in Synthesis and Properties of Pyrazoles

Functional Pyrazolo[1,5-a]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

Microwave Radiations: A Green Approach to the Synthesis of Five- Membered Heterocyclic Compounds

Contact Info

Product

Resources

About