Bicontinuous microemulsions containing Melaleuca alternifolia essential oil as a therapeutic agent for cutaneous wound healing

Assis, Karoll Moangella Andrade de; Leite, Joandra Maísa da Silva; Melo, Demis Ferreira de; Borges, Joyce Cordeiro; Santana, Lucas Matheus Barreto; Reis, Malu Maria Lucas dos; Moreira, Vandiara Martins; Rocha, Wilma Rainny Vieira da; Catão, Raïssa Mayer Ramalho; Santos, Sócrates Golzio dos; Portela, Alyne da Silva; Silva, Samantha Mayara de Sousa; Oliveira, Thárcia Kiara Beserra de; Silveira, João Walter de Souza da; Pires, Emanuene Galdino; Nonaka, Cassiano Francisco Weege; Sanches, Fátima Aparecida Castriani; Damasceno, Bolívar Ponciano Goulart de Lima

doi:10.1007/s13346-020-00850-0

Cited by 14 publications

(9 citation statements)

References 80 publications

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“…Terpinenes (e.g., g- and α-terpinene and terpinen-4-ol) have also shown excellent antioxidant, analgesic, anti-inflammatory, anti-proliferative, and antimicrobial effects [ 94 ]. Most importantly, both terpinenes and 1,8-cineole (eucalyptol) have been recently recognized as promising therapeutic agents for accelerating wound healing and for suppressing microbial burden in skin injuries and dermatological disorders [ 95 , 96 ] via inhibition of the production of pro-inflammatory cytokines and other mediators in injured tissues [ 97 ].…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Mekkaoui

Assaggaf

Qasem

et al. 2021

Foods

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Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits. Dressing mixtures of Thymus vulgaris honey with three essential oils (Origanum vulgare, Rosmarinus officinalis, and Thymus vulgaris) were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time. The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and Thymus vulgaris essential oil, which had wound closure rates of 85.21% and 82.14% in thermal- and chemical-induced burns, respectively, and showed the shortest healing time (14 days) in comparison to other groups. Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials.

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Section: Resultsmentioning

confidence: 99%

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Mekkaoui

Assaggaf

Qasem

et al. 2021

Foods

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“…In recent years, TTO enjoys increased popularity in many topical formulation applied clinically to treat cutaneous infections and oral diseases ( 19 , 20 ) and has been extensively researched in protozoan control, antibiotic alternative, and so on ( 21 , 22 ). With regard to its antiviral effect, it was evidenced that 50% inhibitory concentration (IC50) of TTO for HSV was 0.0009% by plaque assay in vitro ( 23 ) and showed a simultaneously synergistic effect with acyclovir ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Intracellular Replication Inhibitory Effects of Tea Tree Oil on Vesicular Stomatitis Virus and Anti-inflammatory Activities in Vero Cells

Shao

Huang

2021

Front. Vet. Sci.

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Viral disease management has been proven difficult, and there are no broadly licensed vaccines or therapeutics. Vesicular stomatitis virus (VSV) is an active pathogen of wild ungulates and livestock; its infection frequently caused irreversible vesicles on the tongue or other positions, leading to enormous economic loss. Tea tree oil (TTO) has been shown to be a popular remedy for many skin diseases owing to its antibacterial, antipruritic, and anti-inflammatory effects. However, the potential effect of TTO on VSV proliferation and the corresponding inflammatory response in cells remain unclear. In this study, methyl thiazolyl tetrazolium assay was used to evaluate the cell viability of TTO, and cytotoxic concentration 50 (CC50) was calculated. Then, fluorescence observation, reverse transcription–quantitative polymerase chain reaction, Western blot (WB), and flow cytometry (FCM) assay were used to evaluate the antiviral effect of TTO against VSV under three manners of pre-infection before medication, co-administration, pretreatment before infection at safe doses to Vero cells. Meanwhile, the mRNA expressions of interleukin 8, tumor necrosis factor α, and ISG56 in cells were also detected. The results showed that the maximum safe concentration of TTO to Vero cells was 0.063% and the CC50 is 0.32%. Most notably, TTO dose-dependently inhibited the VSV GFP fluorescence generation and restrained the replication of VSV in gene and protein levels regardless of the treatment modes. Based on the results of the FCM, effective concentration 50 of TTO against VSV is 0.019%. Similarly, the mRNA expression of the above cytokines induced by viral infection was also remarkably curbed. These findings suggest that TTO emerged blocking, prophylaxis, and treatment action against VSV replication and suppressed the related inflammation in Vero cells. This study provides a novel potential for TTO fighting against viral infection and anti-inflammatory activities in Vero cells.

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“…Other TTO delivery system was studied [ 89 ] for combating Gram-positive and Gram-negative bacteria and to be used as an antimicrobial and healing agent in skin wounds. Semisolid bicontinuous microemulsions containing TTO is an example, in which a formulation consisting of Kolliphor ® HS 15 (31.05%), Span ® 80 (3.45%), isopropyl myristate (34.5%), and distilled water (31%) with TTO incorporated in the proportion of 3.45% ( v/v ) was selected after optimization through diagram construction [ 89 ].…”

Section: Biological Properties Of Ttomentioning

confidence: 99%

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

et al. 2023

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Acne vulgaris is an inflammatory dermatological pathology that affects mostly young people. However, it can also appear in adulthood, mainly in women. It has a high psychosocial impact, not only at the time of active lesions but also due to the consequences of lesions such as scarring and hyperpigmentation. Several factors are involved in the physiopathology of acne and the constant search for active ingredients is a reality, namely phytotherapeutic ingredients. Tea tree oil is an essential oil extracted from Melaleuca alternifolia (Maiden & Betch) Cheel with known antibacterial, anti-inflammatory, and antioxidant properties, making it a candidate for the treatment of acne. This review aims to describe the various properties of tea tree oil that make it a possible ingredient to use in the treatment of acne and to present several human studies that have evaluated the efficacy and safety of using tea tree oil in the treatment of acne. It can be concluded that tea tree oil has good antibacterial, anti-inflammatory, and antioxidant properties that result in a decrease in the number of inflammatory lesions, mainly papules, and pustules. However, given the diversity of study designs, it is not possible to draw concrete conclusions on the efficacy and safety of this oil in the treatment of acne.

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Bicontinuous microemulsions containing Melaleuca alternifolia essential oil as a therapeutic agent for cutaneous wound healing

Cited by 14 publications

References 80 publications

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Intracellular Replication Inhibitory Effects of Tea Tree Oil on Vesicular Stomatitis Virus and Anti-inflammatory Activities in Vero Cells

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

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