Bicistronic DNA vaccine against Edwardsiella tarda infection in Labeo rohita : Construction and comparative evaluation of its protective efficacy against monocistronic DNA vaccine

Kumari, Ranjeeta; Kole, Sajal; Soman, Praveena; Rathore, Gaurav; Tripathi, Gayatri; Makesh, M.; Rajendran, K. V.; Bedekar, Megha Kadam

doi:10.1016/j.aquaculture.2017.11.052

Cited by 24 publications

(10 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Curiously, fish immunized with the chitosan-based pDNA vaccine by immersion led a lower RPS (72.73%) with respect to the oral route. However, both immunization routes using the chitosan-based pDNA nanovaccine showed higher RPS than the group immunized with the naked pDNA vaccine administered intramuscularly as previously reported in Rhou (Kumari et al 2018) and Tilapia (Cao et al 2014).…”

Section: Oral Nanovaccine-based Chitosan Against Bacterial Diseasessupporting

confidence: 68%

“…However, both immunization routes using the chitosan‐based pDNA nanovaccine showed higher RPS than the group immunized with the naked pDNA vaccine administered intramuscularly as previously reported in Rhou (Kumari et al . 2018) and Tilapia (Cao et al . 2014).…”

Section: Chitosan Npsmentioning

confidence: 99%

“…Another disease for which oral nanovaccines have been developed is edwardsiellosis, a putrefactive systemic disease of both marine and freshwater fish (Mohanty & Sahoo 2007). In an attempt to prevent edwardsiellosis, a pDNA vaccine was developed containing the glyceraldehyde-3phosphate dehydrogenase gene from Edwardsiella tarda along with interferon gamma (IFN) gene from Rohu (Labeo rohita) as adjuvant (Kumari et al 2018). In a previous study, this pDNA vaccine elicited protective immunity (63%) against virulent E. tarda challenge in i.m.…”

Section: Oral Nanovaccine-based Chitosan Against Bacterial Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Developing oral nanovaccines for fish: a modern trend to fight infectious diseases

Angulo

Tello‐Olea

Reyes‐Becerril

et al. 2020

Reviews in Aquaculture

View full text Add to dashboard Cite

Nanovaccines constitute an innovative approach in vaccinology, enabled by the nanotechnology advances on the synthesis, functionalization and application of nanoparticles for immunization. Currently, several organic materials such as chitosan, poly(lactic-co-glycolic acid), nanopoliplexes and virus-like particles (VLPs) have been used for nanovaccine development to fight against fish diseases. The oral route is the most practical and economical for fish vaccination; thus, several oral vaccine candidates have been developed by using NPs in which the antigen is encapsulated, surface exposed or recombinantly ensembled (VLPs), leading to promising results in terms of protection capacity against infectious diseases. In this review, the state of the art on oral nanovaccine prototypes developed for use in fish was analysed and discussed. Oral nanovaccines have showed remarkably possibilities for application in fish aquaculture, which surely will be adopted by the industry in the following years.

show abstract

Section: Oral Nanovaccine-based Chitosan Against Bacterial Diseasessupporting

confidence: 68%

Section: Chitosan Npsmentioning

confidence: 99%

Section: Oral Nanovaccine-based Chitosan Against Bacterial Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Developing oral nanovaccines for fish: a modern trend to fight infectious diseases

Angulo

Tello‐Olea

Reyes‐Becerril

et al. 2020

Reviews in Aquaculture

View full text Add to dashboard Cite

show abstract

“…A bicistronic DNA vaccine was constructed using interferon gamma (IFN-c) gene of rohu (L. rohita) and an antigenic glyceraldehyde-3-phosphate dehydrogenase (GPD) gene of pathogenic E. tarda (Kumari et al 2018). This bicistronic DNA vaccine was conjugated with CNPs via coacervation and termed as CNP-pGPD-IFN (Kole et al 2018).…”

Section: Chitosan Nps/mps Against Bacterial Diseases In Fishmentioning

confidence: 99%

Applications of carbon nanotubes and polymeric micro‐/nanoparticles in fish vaccine delivery: progress and future perspectives

Giri

Kim

Kang

et al. 2021

Reviews in Aquaculture

View full text Add to dashboard Cite

Newly evolving strains of pathogenic microorganisms in aquaculture are posing formidable challenge in controlling and/or eradication of diseases affecting aquaculture. Many research studies have aimed to address this challenge, and the delivery of vaccines using biocompatible nano-delivery systems is widely investigated. Nanoparticles (NPs) have tremendous potential for application as delivery vehicles of novel vaccines. At present, various polymeric and non-polymeric NPs are utilized to deliver vaccines in aquatic species. This review comprehensively discusses recent research advancements in the utilization of carbon nanotubes and polymeric micro-/nanoparticles for the delivery of drug/nutrients to control fish diseases. Further, this review compares the potentials of various vaccine delivery systems utilized to control fish pathogens. The necessity of non-toxic and eco-friendly strategies for aquaculture has also been emphasized in this review.

show abstract

“…Nevertheless, the number of studies that focus on the application of cytokine genes as molecular adjuvants in fish is limited when compared to those undertaken in mammals [21]. To date, it has been reported that fish cytokines such as IL-6 [22], IL-8 [23][24][25], IL-2 [24,26], IL-1β [24,25,27], IL-15, IL-17 [24], TNFα, granulocyte colony-stimulating factors (G-CSF) [25], IL12 [28], chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL19, CCL21 [29], and IFNγ [30] can be applied as promising molecular adjuvants for DNA or recombinant subunit vaccines against particular viral or bacterial infections. Interleukin-34 (IL-34), a cytokine newly discovered in 2008, has been documented as a pluripotent cytokine that modulates a wide array of cellular processes, including differentiation, adhesion, proliferation, survival, metabolism, inflammation, and immune modulators in mammals [31].…”

Section: Introductionmentioning

confidence: 99%

Interleukin 34 Serves as a Novel Molecular Adjuvant against Nocardia Seriolae Infection in Largemouth Bass (Micropterus Salmoides)

2020

View full text Add to dashboard Cite

DNA vaccines have been widely employed in controlling viral and bacterial infections in mammals and teleost fish. Co-injection of molecular adjuvants, including chemokines, cytokines, and immune co-stimulatory molecules, is one of the potential strategies used to improve DNA vaccine efficacy. In mammals and teleost fish, interleukin-34 (IL-34) had been described as a multifunctional cytokine and its immunological role had been confirmed; however, the adjuvant capacity of IL-34 remains to be elucidated. In this study, IL-34 was identified in largemouth bass. A recombinant plasmid of IL-34 (pcIL-34) was constructed and co-administered with a DNA vaccine encoding hypoxic response protein 1 (Hrp1; pcHrp1) to evaluate the adjuvant capacity of pcIL-34 against Nocardia seriolae infection. Our results indicated that pcIL-34 co-injected with pcHrp1 not only triggered innate immunity and a specific antibody response, but also enhanced the mRNA expression level of immune-related genes encoding for cytokines, chemokines, and humoral and cell-mediated immunity. Moreover, pcIL-34 enhanced the protection of pcHrp1 against N. seriolae challenge and conferred the relative percent survival of 82.14%. Collectively, IL-34 is a promising adjuvant in a DNA vaccine against nocardiosis in fish.

show abstract

Bicistronic DNA vaccine against Edwardsiella tarda infection in Labeo rohita : Construction and comparative evaluation of its protective efficacy against monocistronic DNA vaccine

Cited by 24 publications

References 27 publications

Developing oral nanovaccines for fish: a modern trend to fight infectious diseases

Developing oral nanovaccines for fish: a modern trend to fight infectious diseases

Applications of carbon nanotubes and polymeric micro‐/nanoparticles in fish vaccine delivery: progress and future perspectives

Interleukin 34 Serves as a Novel Molecular Adjuvant against Nocardia Seriolae Infection in Largemouth Bass (Micropterus Salmoides)

Contact Info

Product

Resources

About