Applications of carbon nanotubes and polymeric micro‐/nanoparticles in fish vaccine delivery: progress and future perspectives

Giri, Sib Sankar; Kim, Sang Guen; Kang, Jeong Woo; Kwon, Jun; Lee, Sung Bin

doi:10.1111/raq.12547

Cited by 20 publications

(15 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this purpose, the CNTs require functionalization with biologically targeted molecules (sugar, glycolipid, protein, RNA, and DNA). [95] Functionalized CNTs were also considered for vaccine delivery in aquatic [97] and mammal vaccinology. [98] Antibodyproducing B cells in mice were induced when MWCNTs were functionalized with a tetravalent vaccine to prevent the Dengue virus.…”

Section: Applications Of Cnts As Vaccines Adjuvantsmentioning

confidence: 99%

COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

et al. 2023

View full text Add to dashboard Cite

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was responsible for the outbreak of coronavirus disease . The respiratory illness has rapidly spread worldwide and has claimed millions of lives. Although most countries have entered the endemic phase, health authorities warned that future variants could be more virulent than the existing ones. Since clinical trials of antiviral drugs for COVID-19 may last even a year before approval, developing alternative approaches to combat the virus becomes mandatory. Previ-ously, carbon nanotubes (CNTs) have exhibited an impressive track record in controlling numerous viral diseases, including COVID-19. In this article, we review recent applications of CNTs for the prevention, detection, and treatment of COVID-19. We highlight the strategies and prospective developments of CNTs in producing personal protection equipment (PPE), vaccines, immune-triggering, development of biosensors and therapeutic strategies. Finally, the challenges, limitations, and future outlook of CNTs in combating COVID-19 are also discussed.

show abstract

Section: Applications Of Cnts As Vaccines Adjuvantsmentioning

confidence: 99%

COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

et al. 2023

View full text Add to dashboard Cite

show abstract

“…These include the extract of Asparagus racemosus , 211 modified garlic, Allium sativum adjuvant, 178 nanomaterials including single‐walled carbon nanotubes (SWCNTs) 192,212,213 and poly lactic‐ co ‐glycolic acid nanoparticle 214,215 . Although nanoparticles have tremendous potential for application as delivery vehicles of novel vaccines, in‐depth studies on antigen release, cellular uptake and intracellular fate of nanovaccines are required 216 …”

Section: Overview Of Motile Aeromonas Infections In Fish Aquaculturementioning

confidence: 99%

“…214,215 Although nanoparticles have tremendous potential for application as delivery vehicles of novel vaccines, in-depth studies on antigen release, cellular uptake and intracellular fate of nanovaccines are required. 216 Most of the vaccination studies considered the production of antibodies and the RPS as the gold standard for determining vaccine efficiency, as they found a correlation between RPS and antibody titers. 166 However, besides innate and antibody-mediated immunity, adaptive cellular immunity is also elicited by a vaccine, and its role in vaccine efficacy should not be undervalued.…”

Section: Vaccinesmentioning

confidence: 99%

Non‐antibiotic approaches to combat motile Aeromonas infections in aquaculture: Current state of knowledge and future perspectives

Dien

Ngo²,

Nguyen

et al. 2022

Reviews in Aquaculture

View full text Add to dashboard Cite

Inland aquaculture contributed by three major fish groups, including carps, tilapias, and catfish plays a vital role in global food security and nutrition, particularly in low and middle-income countries. However, the sustainable development of this sector is hampered by disease epidemics, especially those caused by bacteria such as Aeromonas species. At least eight pathogenic motile Aeromonas species (A. hydrophila, A. veronii, A. jandaei, A. caviae, A. sobria, A. bestiarum, A. dhakensis and A. schubertii) have been reported in aquaculture with some causing up to 100% mortality during disease outbreaks. Simultaneously, emerging multidrug-resistant Aeromonas due to a long-inappropriate use of antibiotics is alarming and highlights a global public health concern and negative socioeconomic impacts. Here, we provide a comprehensive overview of motile Aeromonas infections, antibiotic use and antimicrobial resistance of Aeromonas species. This contribution also highlights the non-antibiotic approaches (the solutions for preventing or treating of bacterial diseases without resorting to antibiotic use) to control motile Aeromonas infections. In addition to the current state of knowledge and limitations of each prophylaxis/therapy, perspectives for future research are discussed critically, including oral/immersion multivalent vaccines, microencapsulated synbiotics, exogenous metabolites, and novel lytic bacteriophage cocktails. Some emerging applicable nanotechnology themes such as nanovaccines, nanobioactive compounds, and nanobubbles are also included in this review. In

show abstract

“…Carbon nanotubes (CNTs) belong to another important class of inorganic NPs. Their unique properties, such as inertness, biodegradability, non-immunogenicity, and nontoxicity, have enabled CNTs to be developed as safe vaccine scaffolds [159]. CNTs can be divided into two categories depending on their number of layers: single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs).…”

Section: Protein-inorganic Substance Nanoconjugatesmentioning

confidence: 99%

“…CNTs can be divided into two categories depending on their number of layers: single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs). SWCNTs comprise a single graphene cylinder, while MWCNTs comprise multiple coaxial cylinders [159]. Recently, SWCNTs have been extensively studied as carriers to harbor subunit components for the development of fish vaccines [160][161][162][163][164].…”

Section: Protein-inorganic Substance Nanoconjugatesmentioning

confidence: 99%

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Duong

Shalash

et al. 2021

Vaccines

View full text Add to dashboard Cite

The production of subunit nanovaccines relies heavily on the development of a vaccine delivery system that is safe and efficient at delivering antigens to the target site. Nanoparticles have been extensively investigated for vaccine delivery over the years, as they often possess self-adjuvanting properties. The conjugation of antigens to nanoparticles by covalent bonds ensures co-delivery of these components to the same subset of immune cells in order to trigger the desired immune responses. Herein, we review covalent conjugation strategies for grafting protein or peptide antigens onto other molecules or nanoparticles to obtain subunit nanovaccines. We also discuss the advantages of chemical conjugation in developing these vaccines.

show abstract

Applications of carbon nanotubes and polymeric micro‐/nanoparticles in fish vaccine delivery: progress and future perspectives

Cited by 20 publications

References 137 publications

COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

Non‐antibiotic approaches to combat motile Aeromonas infections in aquaculture: Current state of knowledge and future perspectives

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Contact Info

Product

Resources

About