Bicaudate index in computerized tomography of Huntington disease and cerebral atrophy

Barr, Arlene N.; Heinze, W; Dobben, Glen D.; Valvassori, Galdino E.; Sugar, Oscar

doi:10.1212/wnl.28.11.1196

Cited by 94 publications

(37 citation statements)

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“…2 The LeRoux score was calculated from radiographic measurements. 10 Location was classified into the following categories: thalamic, basal ganglia, cortical, cerebellar, brainstem, or subcortical white mat ter.…”

Section: Radiographic Variablesmentioning

confidence: 99%

Predictors of long-term shunt-dependent hydrocephalus in patients with intracerebral hemorrhage requiring emergency cerebrospinal fluid diversion

Zacharia¹,

Vaughan²,

Hickman³

et al. 2012

FOC

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Object Intracerebral hemorrhage (ICH) is frequently complicated by acute hydrocephalus, necessitating emergency CSF diversion with a subset of patients, ultimately requiring long-term treatment via placement of permanent ventricular shunts. It is unclear what factors may predict the need for ventricular shunt placement in this patient population. Methods The authors performed a retrospective analysis of a prospective database (ICH Outcomes Project) containing patients with nontraumatic ICH admitted to the neurological ICU at Columbia University Medical Center between January 2009 and September 2011. A multiple logistic regression model was developed to identify independent predictors of shunt-dependent hydrocephalus after ICH. The following variables were included: patient age, admission Glasgow Coma Scale score, temporal horn diameter on admission CT imaging, bicaudate index, admission ICH volume and location, intraventricular hemorrhage volume, Graeb score, LeRoux score, third or fourth ventricle hemorrhage, and intracranial pressure (ICP) and ventriculitis during hospital stay. Results Of 210 patients prospectively enrolled in the ICH Outcomes Project, 64 required emergency CSF diversion via placement of an external ventricular drain and were included in the final cohort. Thirteen of these patients underwent permanent ventricular CSF shunting prior to discharge. In univariate analysis, only thalamic hemorrhage and elevated ICP were significantly associated with the requirement for permanent CSF diversion, with p values of 0.008 and 0.033, respectively. Each remained significant in a multiple logistic regression model in which both variables were present. Conclusions Of patients with ICH requiring emergency CSF diversion, those with persistently elevated ICP and thalamic location of their hemorrhage are at increased odds of developing persistent hydrocephalus, necessitating permanent ventricular shunt placement. These factors may assist in predicting which patients will require permanent CSF diversion and could ultimately lead to improvements in the management of this disorder and the outcome in patients with ICH.

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Section: Radiographic Variablesmentioning

confidence: 99%

Predictors of long-term shunt-dependent hydrocephalus in patients with intracerebral hemorrhage requiring emergency cerebrospinal fluid diversion

Zacharia¹,

Vaughan²,

Hickman³

et al. 2012

FOC

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“…Cutoff values to segregate persons into normal or abnormal categories were calculated. These values were defined as the mean plus or minus two standard deviations, based on previously reported results in normal controls [5,18,23,241. For FWCC a value less than or equal to 2, and for CCiOTcc a value greater than or equal to 0.1 were considered abnormal.…”

Section: Ct Measzlrementsmentioning

confidence: 99%

A comparison of neurological, metabolic, structural, and genetic evaluations in persons at risk for Huntington's disease

Grafton

Mazziotta

Pahl

et al. 1990

Annals of Neurology

109

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We compared four diagnostic data sets for the assessment of individuals at risk for Huntington's disease. Fifty-four chorea-free persons were evaluated by neurological examination, positron emission tomography measurement of glucose metabolism, radiographic computerized tomographic measurement of caudate size, and genetic testing at the polymorphic DNA loci D4S10, D4S43, and D4S125. Twelve (22%) persons had abnormal caudate metabolism, 6 (11%) had subtle abnormalities of motor control, and 7 (13%) had computed tomographic evidence of caudate atrophy, compared with an expected gene frequency of 34% for this population. In 20 persons with unambiguous genetic test results or the subsequent phenotypic expression of Huntington's disease (chorea), there was a greater sensitivity of the positron emission tomographic measurement of caudate metabolism (75%) relative to computed tomography (33%) or the clinical examination (17%) for the determination of a subpopulation of probable Huntington's disease gene carriers. Hypometabolism of the putamen and globus pallidus, and hypermetabolism of the precentral gyrus were also associated with a high probability of carrying the Huntington's disease gene. The findings support the hypothesis that abnormalities of cerebral metabolism precede clinical or structural (computed tomographic) abnormalities in gene-positive individuals at risk for Huntington's disease.

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“…Some authors have found that bifrontal index has a significant influence on gait disturbance which was probably due to displacement of precentral motor cortex fibres on their way to internal capsule caused by ventricular dilatation [19]. Bicaudate index have been used in several studies to evaluate the caudate atrophy in patients with Huntington's chorea, cerebral atrophy or in multiple sclerosis [20][21][22]. Some authors have found significant correlations between bicaudate index and duration of the Huntington's chorea [23].…”

Section: Indicesmentioning

confidence: 99%

Morphometric Study of Ventricular Indices in Human Brain Using Computed Tomography Scans in Indian Population

Kolsur¹,

P.M²,

Shetty³

et al. 2018

IJAR

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Bicaudate index in computerized tomography of Huntington disease and cerebral atrophy

Cited by 94 publications

References 0 publications

Predictors of long-term shunt-dependent hydrocephalus in patients with intracerebral hemorrhage requiring emergency cerebrospinal fluid diversion

Predictors of long-term shunt-dependent hydrocephalus in patients with intracerebral hemorrhage requiring emergency cerebrospinal fluid diversion

A comparison of neurological, metabolic, structural, and genetic evaluations in persons at risk for Huntington's disease

Morphometric Study of Ventricular Indices in Human Brain Using Computed Tomography Scans in Indian Population

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