Background: Periprosthetic Joint Infection (PJI) remains a great challenge for joint orthopedic surgeons. The purpose of this study is to identify promising research directions by comprehensively analyze the global status and development trend of research in PJI based on bibliometrics and visual analysis.Methods: Overall the literature about PJI from 1994 to 2020 was searched from Web of Science Core Collection (WOSCC). The extracted data (author, journal, institution, country or region, research orientation, support fund, Cited situation) were analyzed by bibliometrics. VOSviewer was used for bibliographic coupling, co-citation, co-authorship, co-occurrence analysis. According to the results of visual analysis, this paper explores the global status and hot prediction direction of PJI.Results: A total of 2,283 eligible publications were retrieved. In terms of the trend of previous years, an increasing number of PJI publications will be published. Among the countries in the world, the United States has the largest contribution to the field of PJI. Although “Journal of Arthroplasty” has published the largest number of articles, the most influential journal is "Clinical Orthopaedics and Related Research”. Thomas Jefferson University has the largest number of publications of any organization. The study of PJI can be divided into four clusters: "Study on diagnosis", "Related risk factors", "Study on treatment", and "Study on anti-biofilm in vitro". The diagnosis and risk factors of PJI is considered to be a hot direction in the future direction.Conclusions: In recent years, the literature related to PJI has presented a continuous growth trend. The United States is the largest contributor to this field. More attention should be paid to the diagnostic and risk factors of PJI, which may be the future hot spots in this field.