Biaxial rupture properties of ascending thoracic aortic aneurysms

Duprey, Ambroise; Trabelsi, Olfa; Vola, Marco; Favre, Jean‐Pierre; Avril, Stéphane

doi:10.1016/j.actbio.2016.06.028

Cited by 109 publications

(114 citation statements)

References 61 publications

(92 reference statements)

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“…"> 2.The second situation is with the luminal side of the aorta outside so that the aorta is mounted upside down in the device (Figure B). Experimentally, this situation was used to permit painting the surface and track the deformation during the test with DIC . Indeed, the luminal surface is smoother and cleaner, permitting a better optical contrast.…”

Section: Resultsmentioning

confidence: 99%

“…Biaxial tests are more appropriate to determine if the tissue shows different properties between the axial and circumferential directions. An appropriate alternative to investigate the biaxial mechanical behavior of the arterial walls can be bulge inflation technique . Quasi‐static bulge inflation tests of Mohan and Melvin on 16 healthy descending aortas demonstrated that the rupture of aortic tissue is always oriented in the circumferential direction.…”

Section: Introductionmentioning

confidence: 99%

“…This is consistent with the results of Marra et al obtained from inflation tests on porcine healthy aortic tissues. Inflation tests using ATAA specimens were recently performed by Duprey et al up to rupture. They derived for all the samples the average Cauchy stress at which the rupture occurred.…”

Section: Introductionmentioning

confidence: 99%

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Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms

Mousavi

Farzaneh

2017

Numer Methods Biomed Eng

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Dissections of ascending thoracic aortic aneurysms (ATAAs) cause significant morbidity and mortality worldwide. They occur when a tear in the intima-media of the aorta permits the penetration of the blood and the subsequent delamination and separation of the wall in 2 layers, forming a false channel. To predict computationally the risk of tear formation, stress analyses should be performed layer-specifically and they should consider internal or residual stresses that exist in the tissue. In the present paper, we propose a novel layer-specific damage model based on the constrained mixture theory, which intrinsically takes into account these internal stresses and can predict appropriately the tear formation. The model is implemented in finite-element commercial software Abaqus coupled with user material subroutine. Its capability is tested by applying it to the simulation of different exemplary situations, going from in vitro bulge inflation experiments on aortic samples to in vivo overpressurizing of patient-specific ATAAs. The simulations reveal that damage correctly starts from the intimal layer (luminal side) and propagates across the media as a tear but never hits the adventitia. This scenario is typically the first stage of development of an acute dissection, which is predicted for pressures of about 2.5 times the diastolic pressure by the model after calibrating the parameters against experimental data performed on collected ATAA samples. Further validations on a larger cohort of patients should hopefully confirm the potential of the model in predicting patient-specific damage evolution and possible risk of dissection during aneurysm growth for clinical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms

Mousavi

Farzaneh

2017

Numer Methods Biomed Eng

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“…The restricted boundary nodes limited the longitudinal deformation of the aorta model. Although the “almost-true” stress alone can be used in many applications, such as using the stress-based rupture potential index as an aneurysm rupture risk predictor [39], different tissue damage and failure models exist such as accumulated energy [40, 41], stretch based criterion [42] and distensibility [43] which rely on the deformation and thus depend on patient-specific material properties. Previous works in our group [17] showed that the failure pressure of ascending aortic aneurysm was much higher than the measured systolic pressure, and the failure behavior of the aorta were highly correlated with material properties.…”

Section: Discussionmentioning

confidence: 99%

A new inverse method for estimation of in vivo mechanical properties of the aortic wall

Liu

Liang

Sun

2017

Journal of the Mechanical Behavior of Biomedical Materials

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The aortic wall is always loaded in vivo, which makes it challenging to estimate the material parameters of its nonlinear, anisotropic constitutive equation from in vivo image data. Previous approaches largely relied on either computationally expensive finite element models or simplifications of the geometry or material models. In this study, we investigated a new inverse method based on aortic wall stress computation. This approach consists of the following two steps: (1) computing an “almost true” stress field from the in vivo geometries and loading conditions, (2) building an objective function based on the “almost true” stress fields, constitutive equations and deformation relations, and estimating the material parameters by minimizing the objective function. The method was validated through numerical experiments by using the in vivo data from four ascending aortic aneurysm (AsAA) patients. The results demonstrated that the method is computationally efficient. This novel approach may facilitate the personalized biomechanical analysis of aortic tissues in clinical applications, such as in the rupture risk analysis of ascending aortic aneurysms.

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“…The mechanical properties of the ATA wall show directional dependency [17,18,19,20] and that it is inhomogeneous with respect to region and the aortic layers [8,13,17,19]. The mechanical response of the ATA is governed by the properties of its layers, the intima, media, and adventitia, which could be associated with non-uniform tissue remodelling during the progression of aortic aneurysms [21,22].…”

Section: Introductionmentioning

confidence: 99%

Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms

et al. 2016

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An aortic aneurysm is a lethal arterial disease that mainly occurs in the thoracic and abdominal regions of the aorta. Thoracic aortic aneurysms are prevalent in the root/ascending parts of the aorta and can lead to aortic rupture resulting in the sudden death of patients. Understanding the biomechanical and histopathological changes associated with ascending thoracic aortic aneurysms (ATAAs), this study investigates the mechanical properties of the aorta during strip-biaxial tensile cycles. The loss factor—defined as the ratio of dissipated energy to the energy absorbed during a tensile cycle—the incremental modulus, and their anisotropy indexes were compared with the media fiber compositions for aneurysmal (n = 26) and control (n = 4) human ascending aortas. The aneurysmal aortas were categorized into the aortas with bicuspid aortic valves (BAV) and tricuspid aortic valves (TAV). The strip-biaxial loss factor correlates well with the diameter of the aortas with BAV and TAV (for the axial direction, respectively, R2 = 0.71, p = 0.0022 and R2 = 0.54, p = 0.0096). The loss factor increases significantly with patients’ age in the BAV group (for the axial direction: R2 = 0.45, p = 0.0164). The loss factor is isotropic for all TAV quadrants, whereas it is on average only isotropic in the anterior and outer curvature regions of the BAV group. The results suggest that loss factor may be a useful surrogate measure to describe the histopathology of aneurysmal tissue and to demonstrate the differences between ATAAs with the BAV and TAV.

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Biaxial rupture properties of ascending thoracic aortic aneurysms

Cited by 109 publications

References 61 publications

Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms

Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms

A new inverse method for estimation of in vivo mechanical properties of the aortic wall

Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms

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