Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitution

Anomalous rate dependence of the preconditioned response of soft tissue during load controlled deformation

“…1) that when tests are run under load control, higher loading rates can result in more compliant, fully preconditioned material behavior. This response has not yet been documented to the knowledge of the authors, a likely consequence of stretch control being a simpler mode of deformation in practice when dealing with nonlinear materials such as soft tissue; additionally, when load controlled cyclic testing has been performed, only the elastic material response for a single period of deformation has been reported (Lu et al, 2005;Nagatomi et al, 2004;Wells and Sacks, 2002;Billiar and Sacks, 2000). This study investigates the effects of stretch and loading rate on the behavior of soft tissue through the use of viscoelastic material models.…”

“…Numerous investigators have reported elastic data (e.g. the loading curve) from planar biaxial tension tests run under either load control (Lu et al, 2005;Nagatomi et al, 2004;Wells and Sacks, 2002;Billiar and Sacks, 2000) or stretch control (May-Newman and Yin, 1998;Humphrey and Yin, 1988;Chen et al, 2004). While the associated experimental protocols include preconditioning, only the elastic material response was modeled and thus the effects of the control mechanism on preconditioned viscoelastic material behavior were not reported.…”

Equibiaxial strain stimulates fibroblastic phenotype shift in smooth muscle cells in an engineered tissue model of the aortic wall

“…While most biaxial test systems for mechanical property testing involve suturing long threads at the periphery of test specimens [22,23], this is not possible for weaker tissues like collagen hydrogels. Precoating the silicone membrane with Cell-Tak, a mixture of adhesive proteins extracted from the marine mussel, Mytilus edulis, greatly enhanced construct adhesion.…”

Multi‐potent differentiation of human purified muscle‐derived cells: potential for tissue regeneration

“…We also found that the murine MDCs could be incorporated into acellular scaffold (small intestinal submucosa, SIS) with the formation of myotubes, and be responsible for contractile activity [17] which could also increase the compliance of SIS as a potential functional biomaterial [18].…”