BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo

Nieto-Veloza, Andrea; Wang, Zhihong; Zhong, Qixin; Krishnan, Hari B.; Dia, Vermont P.

doi:10.3390/antiox8060175

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…In a study, M. charantia extracts decreased the expression of intercellular adhesion molecule and tumor suppressor (miR-221/222) in tumor necrosis-factor-alpha-treated mouse lung tissues, while reducing factors with a critical role in biological processes, such as immunity, inflammation, cell growth and survival, and development (PI3K/Akt/NF B/IB). Therefore, the administration of MC extracts prior to tumor necrosis factor alpha (TNF-α) suggests that supplementation with bitter melon might be advantageous as a chemo-preventive agent for individuals at risk of inflammatory-related diseases [85]. Another study showed that glucan endo-1,3-beta-glucosidase (BG-4), a 4 kilodaltons (kDa) peptide extracted from bitter gourd seeds using 70% ethanol, has exceedingly strong trypsin-inhibiting activity [86].…”

Section: Anti-inflammatory and Antioxidant Activitymentioning

confidence: 99%

Importance of Certain Varieties of Cucurbits in Enhancing Health: A Review

Romo-Tovar,

Belmares Cerda,

Chávez-González

et al. 2024

Foods

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The Cucurbitaceae family is an extensive group of fruits and vegetables that exhibit common characteristics; for example, they are farmed on a global scale and exhibit a wide range of applications, including fresh consumption and use in various food and beverage products. As is frequent, many species or genera share a common name, and this can lead to some confusion when looking for information about a specific variety. In this review, we describe the findings about the biological activity, like antibacterial, antiviral, antidiabetic, and anticancer properties, of two genera of this family, Cucumis and Momordica, which have been characterized and evaluated in several research studies and regarding which information is readily accessible. Those activities rely on the various physicochemical qualities and nutritional content of each variety, including factors like β-carotene and polyphenols, among others. The goal of this review is to provide a rapid search for each activity examined in the literature, enabling future research on their potential uses in functional foods and nutraceutical supplements.

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Section: Anti-inflammatory and Antioxidant Activitymentioning

confidence: 99%

Importance of Certain Varieties of Cucurbits in Enhancing Health: A Review

Romo-Tovar,

Belmares Cerda,

Chávez-González

et al. 2024

Foods

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“…Cell culture and treatment. RAW 264.7 murine macrophages activated with lipopolysaccharide (LPS) were used as an in vitro model of inflammation following the methods described by [19,20]. Cells were grown in DMEM media supplemented with 10% heat-inactivated FBS and 1% of penicillin/streptomycin at 37 ºC in a humidified 5% CO 2 incubator.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil

et al. 2023

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The purpose of this study was to extract, identify, and quantify the phenolic compounds in grumixama (Eugenia brasilienses Lam.) and guabiju (Myrcianthes pungens), native fruits from southern region of Brazil, and to explore their antioxidant and anti-inflammatory properties. The phenolic compounds were extracted with acidified water and acidified methanol and evaluated for their bioactive constituents, antioxidant capacity, and anti-inflammatory properties. Spectrophotometric quantification shows tannins to be the most prevalent at 2.3 to 5.8 g/100g fresh fruit with acidified methanol containing higher concentrations of different phenolics than acidified water. HPLC analysis indicates that gallic acid, catechin, vanillic acid, and ellagic acid are the most prevalent phenolics in the two fruits extracts. Scavenging of DPPH and NO radicals showed inhibition by as much as 95% and 80%, respectively, at 2.5 gallic acid equivalent (GAE)/mL of the extract. At 50 μg GAE/mL, the release of pro-inflammatory molecules NO and IL-6 was significantly reduced with acidified methanol extract having higher inhibitory activity. Our results revealed that these native fruits, grown in the south of Brazil, are rich sources of phenolic compounds and have great antioxidant and anti-inflammatory activity.

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“…67 BG-4, an active molecule extracted from bitter melon, is also a polypeptide molecule that has an anti-inflammatory effect through the NF-κB pathway. 68,69 Mass spectrometry analysis shows that it consists of four peptide chains that exerts anti-inflammatory effects primarily through reducing the nuclear translocation of NF-κB p65 subunit. 68 Besides, BG-4 can also act as an anti-tumor factor by promoting the apoptosis of intestinal cancer cells.…”

Section: Anti-tumor Peptidementioning

confidence: 99%

Emerging self-assembling peptide nanomaterial for anti-cancer therapy

et al. 2021

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Recently it is mainly focused on anti-tumor comprehensive treatments like finding target tumor cells or activating immune cells to inhibit tumor recurrence and metastasis. At present, chemotherapy and molecular-targeted drugs can inhibit tumor cell growth to a certain extent. However, multi-drug resistance and immune escape often make it difficult for new drugs to achieve expected effects. Peptide hydrogel nanoparticles is a new type of biological material with functional peptide chains as the core and self-assembling peptide (SAP) as the framework. It has a variety of significant biological functions, including effective local inflammation suppression and non-drug-resistant cell killing. Besides, it can induce immune activation more persistently in an adjuvant independent manner when compared with simple peptides. Thus, SAP nanomaterial has great potential in regulating cell physiological functions, drug delivery and sensitization, vaccine design and immunotherapy. Not only that, it is also a potential way to focus on some specific proteins and cells through peptides, which has already been examined in previous research. A full understanding of the function and application of SAP nanoparticles can provide a simple and practical strategy for the development of anti-tumor drugs and vaccine design, which contributes to the historical transition of peptide nanohydrogels from bench to bedside and brings as much survival benefits as possible to cancer patients.

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BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo

Cited by 12 publications

References 34 publications

Importance of Certain Varieties of Cucurbits in Enhancing Health: A Review

Importance of Certain Varieties of Cucurbits in Enhancing Health: A Review

Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil

Emerging self-assembling peptide nanomaterial for anti-cancer therapy

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