Bevacizumab treatment for acquired vitelliform detachment in patient with cuticular drusen

Morillo, M.J.; González-Escobar, A.B.; Baquero, I.; García-Campos, J.M.

doi:10.1016/j.oftale.2012.09.015

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…With progression of disease, secondary complications of vitelliform lesions such as macular hole and choroidal neovascularization have been reported, although the major concern is atrophy. [26][27][28][29][30][31][32] The yellow vitelliform material can eventually resolve or persist, but if they resolve, atrophy of the RPE and photoreceptors is the typical result. This legacy of outer retinal atrophy after resolution of vitelliform material was seen in all 3 cases of cloudy vitelliform submaculopathy.…”

Section: We Present 3 Unique Cases Of Unilateral Transientmentioning

confidence: 99%

“…More recently, acquired vitelliform lesions, defined as subretinal accretion of clinically yellow, hyper-autofluorescent material above the RPE band and within the macular region not owing to acquired vitelliform macular dystrophies, 26 have been described in association with a variety of conditions, including cuticular drusen, reticular pseudodrusen, serous pigment epithelial detachment, pseudoxanthoma elasticum with angioid streaks, vitreomacular traction, central serous chorioretinopathy, immunogammopathies, and acute exudative paraneoplastic polymorphous vitelliform maculopathy. [26][27][28][29][30][31][32][33][34] We present 3 patients with cloudy subretinal vitelliform maculopathy that showed features distinct from pseudovitelliform macular dystrophy and acquired vitelliform lesions, resolved spontaneously within 3 months of initial presentation, and were ultimately recognized to have underlying primary vitreoretinal lymphoma and/or primary central nervous system lymphoma. The transient nature of this retinopathy suggests a paraneoplastic process.…”

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confidence: 99%

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Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Pang

Shields

Jumper

et al. 2014

American Journal of Ophthalmology

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Section: We Present 3 Unique Cases Of Unilateral Transientmentioning

confidence: 99%

mentioning

confidence: 99%

Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Pang

Shields

Jumper

et al. 2014

American Journal of Ophthalmology

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“…1 In non-exudative AMD, AVLs were reported to be associated with various types of drusen, such as cuticular drusen, subretinal drusenoid deposits, and large drusen. 2–4…”

Section: Introductionmentioning

confidence: 99%

Choroidal structural features of acquired vitelliform lesions in non-exudative age-related macular degeneration

Demirel

Yanık

Özcan

et al. 2022

European Journal of Ophthalmology

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Purpose To define the choroidal morphological characteristics of non-exudative age-related macular degeneration (AMD) cases associated with acquired vitelliform lesions (AVLs). Methods This retrospective study included intermediate AMD patients with AVLs (Group1, 21eyes) and without AVLs (Group2, 21eyes). A healthy control group was (Group3, 23eyes) also included. Subfoveal choroidal thickness (SFCT), greatest basal diameter (GBD), and maximum height (MH) of the largest PED were measured on spectral domain optical coherence tomography. Internal reflectivity of PEDs and total choroidal area (TCA) were measured using ImageJ software. The TCA was binarized to the luminal area (LA) and stromal area. The choroidal vascularity index (CVI) was assessed. Results The mean SFCT, TCA, and LA were higher in Group 1 (290.3 ± 86.8 μm, 0.840 ± 0.302 mm2, 0.602 ± 0.227 mm2) than in Group 2 (215.6 ± 85.0 μm, 0.594 ± 0.183 mm2, 0.429 ± 0.139 mm2) ( p = 0.014, p = 0.017, p = 0.020, respectively). There was no significant difference in the CVI measurements between Group 1 and Group 2 (p = 1.000). The mean GBD and MH of the PED was higher in Group 1 (1443 ± 595 µm, 188 ± 86 µm) than in Group 2 (851 ± 368 µm, 119 ± 38 µm) ( p = <0.001, p = 0.001, respectively). Internal PED reflectivity was significantly lower in Group 1 (0.44 ± 0.21) than in Group 2 (0.66 ± 0.17) ( p = <0.001). Internal PED reflectivity showed negative correlation with GBD and MH of the PED in Group 1 (r = −0.587, p = 0.005; rho = −0.448, p = 0.042, respectively). In Group 2, internal PED reflectivity had a negative correlation with MH of the PED (rho = −0.511, p = 0.018). Conclusion Non-exudative AMD patients with AVLs are more prone to have a thick choroid and large hyporeflective PEDs as compared to the those without AVLs.

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“…1 Different types of drusen, including cuticular drusen, subretinal drusenoid deposits, and large drusen, were also reported to be accompanied by AVLs. 2,5,6 The natural course of AVLs starts with an initial period of accumulation, followed by resorption. However, the literature specifically evaluating the natural course of dry AMD in the setting of AVLs is limited.…”

Section: Introductionmentioning

confidence: 99%

“…1 Different types of drusen, including cuticular drusen, subretinal drusenoid deposits, and large drusen, were also reported to be accompanied by AVLs. 2,5,6…”

Section: Introductionmentioning

confidence: 99%

Natural course of acquired vitelliform lesions associated with pigment epithelial detachments in dry age related macular degeneration

Yanık

Demirel

Batıoğlu

et al. 2021

European Journal of Ophthalmology

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Purpose: To describe the natural history of acquired vitelliform lesions (AVLs) associated with different types of pigment epithelial detachments (PEDs) in dry age-related macular degeneration. Methods: A retrospective review of clinical examination and multimodal imaging data of patients with AVLs associated with PED(s) was performed. Results: This study included 25 eyes of 17 patients. The mean age of patients was 67.2 ± 9.7 (47–83) years. The mean follow-up time was 32.6 ± 16.2 (12–66) months, excluding four patients (five eyes) that were lost to follow-up. The mean logMAR BCVA was 0.21 ± 0.16 at baseline and 0.38 ± 0.28 at final visit ( p = 0.016). At the end of the follow-up period, PEDs enlarged in eight eyes (40%) and were unchanged in two eyes (10%). Spontaneous resolution of the central PED(s) with AVLs was seen in four (20%) eyes. Rupture of the PED(s) occurred in four eyes (20%), with two developing central foveolar atrophy afterwards. Overall, central foveolar atrophy was seen ultimately in four eyes (20%). Conclusion: It seems that high PED size may be a risk factor for PED rupture during follow-up. 1/3 of the eyes ended up with unfavorable anatomical outcome.

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Bevacizumab treatment for acquired vitelliform detachment in patient with cuticular drusen

Cited by 3 publications

References 5 publications

Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Choroidal structural features of acquired vitelliform lesions in non-exudative age-related macular degeneration

Natural course of acquired vitelliform lesions associated with pigment epithelial detachments in dry age related macular degeneration

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