Current debates around the Anthropocene tend to focus on recent planetary-scale processes. However, regional and small-scale processes can be very telling about human agency in the shaping of landscapes overtime. Indeed, anthropogenic impacts of different intensities can be observed on landscapes since Prehistory – even in such remote and allegedly marginal areas as deserts, wetlands or mountains. In this article, I reflect on the long-term anthropization of alpine and subalpine areas in the western area of the Cantabrian Mountains (North-West of Iberia) in Later Prehistory. Studying the earlier anthropogenic pressure on upland environs in this period reminds us of the potential of landscape archaeology to enhance interdisciplinarity in debates about the Anthropocene. With the aim of emphasizing the role of archaeology as a mediating arena between social sciences, humanities and earth sciences, I analyse the scarce archaeological information available for upland landscapes of this study area to show how these datasets can nuance evolutionary interpretations of paleo-environmental sequences studied at natural deposits. Only through integrated and comprehensive discussions around the cultural and environmental traits of landscapes will we be able to fully understand the complex social contexts where agrarian labour and collective action shaped the alpine and subalpine areas in the Cantabrian Mountains since the spread of the Neolithic.