“…Especially noncardioselective ,B-adrenoceptor blockers such as timolol, metipranolol, carteolol, levobunolol, pindolol, befunolol, and others result in systemic Iadrenoceptor blockade in healthy volunteers (Bacon et al, 1989, Berlin et al, 1987Cervantes et al, 1986;LeJeunne et al, 1990;Mekki et al, 1984) as well as in patients with obstructive airway disease (Cervantes et al, 1986;Dunn etal., 1986;Hugues etal., 1987;Schoene et al, 1984;Spiritus & Casciari, 1985). Systemic ,3-adrenoceptor blocking effects have been reported to be minimal or completely absent in patients with obstructive airway disease following cardioselective ocular betaxolol (Brooks et al, 1987;Cervantes et al, 1986;Dunn et al, 1986;Ofner & Smith, 1987;Schoene etal., 1984;Spiritus & Casciari, 1985;Van Buskirk et al, 1986).…”