Betaine-Palmitate Reduces Acetylsalicylic Acid-induced Gastric Damage in Rats

Zöllei, I; Szabó, Andrea; Kaszaki, József; Tiszlavicz, László; Ghyczy, Miklós; Boros, Mihály

doi:10.1080/003655201750313324

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…The dose of salicylate employed in the present study was more than 50-fold greater than the dose of aspirin recommended for prevention of CVD/events in humans (ie, 81 mg) but less than half the aspirin dose described to induce ulcers in mice (52). Whereas chronic low-dose aspirin typically is used prophylactically in humans for its COX-dependent antithrombotic effects, salicylates, metabolites of aspirin, are much less effective COX inhibitors (53).…”

Section: Clinical Relevancementioning

confidence: 83%

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor B and Forkhead Box O Phosphorylation

Lesniewski

Durrant

Connell

et al. 2011

The Journals of Gerontology Series A: Biological Sciences and M

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We hypothesized that I kappa B kinase (IKK)-mediated nuclear factor kappa B and forkhead BoxO3a phosphorylation will be associated with age-related endothelial dysfunction. Endothelium-dependent dilation and aortic protein expression/phosphorylation were determined in young and old male B6D2F1 mice and old mice treated with the IKK inhibitor, salicylate. IKK activation was greater in old mice and was associated with greater nitrotyrosine and cytokines. Endothelium-dependent dilation, nitric oxide (NO), and endothelial NO synthase phosphorylation were lower in old mice. Endothelium-dependent dilation and NO bioavailability were restored by a superoxide dismutase mimetic. Nuclear factor kappa B and forkhead BoxO3a phosphorylation were greater in old and were associated with increased expression/activity of nicotinamide adenine dinucleotide phosphate oxidase and lower manganese superoxide dismutase expression. Salicylate lowered IKK phosphorylation and reversed age-associated changes in nitrotyrosine, endothelium-dependent dilation, NO bioavailability, endothelial NO synthase, nuclear factor kappa B and forkhead BoxO3a phosphorylation, nicotinamide adenine dinucleotide phosphate oxidase, and manganese superoxide dismutase. Increased activation of IKK with advancing age stimulates nuclear factor kappa B and inactivates forkhead BoxO3a. This altered transcription factor activation contributes to a pro-inflammatory/pro-oxidative arterial phenotype that is characterized by increased cytokines and nicotinamide adenine dinucleotide phosphate oxidase and decreased manganese superoxide dismutase leading to oxidative stress-mediated endothelial dysfunction.

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Section: Clinical Relevancementioning

confidence: 83%

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor B and Forkhead Box O Phosphorylation

Lesniewski

Durrant

Connell

et al. 2011

The Journals of Gerontology Series A: Biological Sciences and M

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“…Betaine plays a role in reducing the level of homocysteine, which is a toxic byproduct of amino acid metabolism that may promote atherosclerosis and osteoporosis, in blood, , and it is also sometimes taken as a nutritional supplement to protect against chemical damage to the liver. , Betaine hydrochloride is used as a digestive aid and is particularly helpful for people with insufficient acid production in the stomach. Furthermore, betaine and its palmitic acid complex (betaine-palmitate) protect the gastric mucosa . Betaine is also used as a toothpaste ingredient, and the daily use of topical products containing olive oil, betaine, and xylitol has been found to provide safe and effective relief of the dry mouth symptoms in a population with polypharmacy-induced xerostomia …”

Section: Introductionmentioning

confidence: 99%

Equilibrium Distribution Model of Betaine between Surfactant Micelles and Water: Application to a Micellar-Enhanced Ultrafiltration Process

Ruiz

Benito

Barriuso

et al. 2010

Ind. Eng. Chem. Res.

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The aim of this work was to determine the optimal surfactant concentration and operating conditions for betaine recovery from aqueous solutions by micellar-enhanced ultrafiltration (MEUF). Initial centrifugal ultrafiltration experiments with commercial 5 kDa cutoff polyethersulfone membranes showed that optimal betaine extraction was achieved with 200 mol/m3 of sodium dodecyl sulfate (SDS) as surfactant, at pH 1, with phosphoric acid for pH adjustment. The degree of betaine extraction increased with SDS concentration but remained constant with increasing betaine concentration for a given initial SDS concentration. The equilibrium distribution constants, K S, of betaine between SDS micelles and water were determined assuming a theoretical pseudophase separation model. Continuous MEUF with a 5 kDa cutoff TiO2 tubular ceramic membrane was performed in order to concentrate the micellar solution. Complete rejection of the micelles by the membrane was observed, resulting in 54% of the betaine and 99% of the SDS in micellar form, in agreement with the values estimated using the proposed theoretical model.

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Integrating untargeted metabonomics, partial least square regression analysis and MetPA to explore the targeted pathways involved into Huangqi Jiangzhong Tang against chronic atrophic gastritis rats

Cui

et al. 2017

Chemometrics and Intelligent Laboratory Systems

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Betaine-Palmitate Reduces Acetylsalicylic Acid-induced Gastric Damage in Rats

Abstract: Betaine-palmitate affords a significant protective effect against ASA-induced injury, without influencing the ATP synthesis, and this suggests that the defence is due to its ability to prevent secondary damage.

Cited by 8 publications

References 29 publications

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor B and Forkhead Box O Phosphorylation

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor B and Forkhead Box O Phosphorylation

Equilibrium Distribution Model of Betaine between Surfactant Micelles and Water: Application to a Micellar-Enhanced Ultrafiltration Process

Integrating untargeted metabonomics, partial least square regression analysis and MetPA to explore the targeted pathways involved into Huangqi Jiangzhong Tang against chronic atrophic gastritis rats

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