Beta2-Microglobulin Levels in Serum and Saliva of Patients with Juvenile Periodontitis.

Abstract

Beta2-microglobulin (ƒÀ2-m) is a low-molecular-weight protein which has been suggested to play an important role in immune functions. The aim of this study was to determine ƒÀ2-m levels in serum and saliva from patients with juvenile periodontitis (JP) and to compare them with those of periodontally healthy subjects. The study was performed on 11 patients with JP and 10 periodontally healthy controls (C). Clinical measurements were recorded and serum and saliva samples were obtained from the individuals. ƒÀ2-m levels were determined using the ELISA technique. Serum ƒÀ2-m levels were significantly higher in the JP group than in the control group. In saliva, no significant difference in ƒÀ2-m levels between the groups was found. The higher ,ƒÀ2-m levels in serum in the JP group suggest that ƒÀ2-m may play a role as a systemic factor in the etiology and pathogenesis of JP.

Antimicrobial peptides of the oral cavity

“…Similarly, beta‐2‐microglobulin levels are higher in gingival crevicular fluid from patients with periodontal than in gingival crevicular fluid from healthy controls (225). However, this difference was not noted in a study of juvenile periodontitis saliva, where the beta‐2‐microglobulin level did not differ between patients and controls, while serum levels were higher in periodontitis patients than in controls (5). Beta‐2‐microglobulin causes agglutination of S. mutans in the presence of 1.4 m m Ca 2+ (66).…”

Proteomic Analysis of Human Whole and Parotid Salivas Following Stimulation by Different Tastes

“…As for beta-2-microglobulin, increased levels have been reported in saliva in the cases of autoimmune disorders 34,35 and in juvenile periodontitis. 36 Therefore, over-representation of these two proteins after a strong sour taste again suggests an association with an immunological-type reaction.…”

Oral antimicrobial peptides: Types and role in the oral cavity

“…In the higher vertebrates, prior to the evolution of adaptive immunity, a more simpler and nonspecific system of innate immunity evolved and still continues to play a role as the principal defense system for almost all living organisms (Adonogianaki et al, 1993, Adonogianaki et al, 1996, Aguilera et al, 1998). The innate immunity modulates its antimicrobial functionality by small cationic peptides with activity against gram-positive and negative bacteria, parasites, fungi and some viruses (Akalin et al, 1993, Allaker et al, 1999, Allgrove et al, 2008). The mechanism of action against microbes and pathogens is principally attributed to the disruption of the microbial cell membrane (van‘t Hof et al, 2001, Shai, 2002).…”