Beta-Thromboglobulin and Platelet Factor 4 Levels in Pregnancy and Preeclampsia

Ayhan, Ali; Akkök, Erol; Urman, Bülent; Yaralı́, Hakan; Dündar, Serkan; Kirazli, S

doi:10.1159/000293203

Cited by 26 publications

(21 citation statements)

References 15 publications

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“…Previous studies have demonstrated that both β‐TG and PF‐4 concentrations increased significantly in pre‐eclampsia compared to normotensive pregnancy, and a further increment was observed with the severity of pre‐eclampsia (26, 27). In normotensive pregnancy in the present study, the β‐TG concentration showed a significant increase, whereas PF‐4 concentration did not differ.…”

Section: Discussionmentioning

confidence: 99%

Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre‐eclampsia

Hayashi¹,

Inoue

Hoshimoto³

et al. 2002

European J of Haematology

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Platelet aggregation, vascular constriction, and thrombin formation (detected by 11-DTXB2/Cr and TAT) may be markedly enhanced even in group 2, but further enhancement may be relatively slight in groups 3 and 4. In contrast, endothelial damage (determined by TM) and platelet release of PF-4 may not increase significantly in group 2, but they may increase in group 4. Platelet-release of beta-TG may be enhanced in groups 2, 3, and 4. Endothelial damage and platelet-releasing reaction (detected by PF-4 and beta-TG) may be significantly more enhanced in group 4 than in group 3.

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Section: Discussionmentioning

confidence: 99%

Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre‐eclampsia

Hayashi¹,

Inoue

Hoshimoto³

et al. 2002

European J of Haematology

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“…A potential explanation for the latter is physiological activation (with associated partial release of granule contents) of platelets during pregnancy . In keeping with this, plasma PF4 levels are increased in pregnancy . Interestingly, while albumin levels were reduced in the PR, fibrinogen (FG) levels were increased.…”

Section: Resultsmentioning

confidence: 81%

The Platelet Releasate is Altered in Human Pregnancy

Szklanna

Parsons

Wynne

et al. 2018

Proteomics Clinical Apps

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Purpose: Healthy pregnancy is characterized by an increase in platelet activation and a decrease in the number of circulating platelets with gestation. Despite this recognized importance, proteomic studies investigating platelets in healthy pregnancy have not been performed. As platelet cargo can be altered in different conditions, it is hypothesized that platelets may store a relevant and bespoke collection of molecules during pregnancy. Experimental design: Comparative label-free quantitative proteomic profiling of platelet releasates (PRs) is performed from 18 healthy pregnant and 13 non-pregnant women using an MS/MS approach. Results: Of the 723 proteins identified, 69 PR proteins are found to be differentially released from platelets in pregnancy, including proteins only expressed during pregnancy such as pregnancy-specific glycoproteins and human placental lactogen. Moreover, the population of exosomal vesicles present in the PR is also modified in pregnancy. Receiver operating characteristic analysis shows the predictive ability of 11 PR proteins to distinctly classify pregnant and nonpregnant women with an area under the curve of 0.876, a sensitivity of 88.9%, and a specificity of 84.6%. Conclusions and clinical relevance: Taken together this demonstrates that platelets and their released cargo are 'educated' in physiologic stressful conditions such as pregnancy and may represent a promising platform to study pregnancy complications.

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“…-thromboglobulin (BTG) is an index of invivo platelet activation. There is controversy regarding BTG where both increased [29] and normal [30,31] levels were reported. Adenosine deaminase (ADA) is the enzyme that breaks down adenosine -an inhibitor of platelet aggregation.…”

Section: Qualitative Changes In Platelets and Activation Markersmentioning

confidence: 99%

A Review of Hemostasis in Normal Pregnancy and Puerperium

Moiz¹

2017

Natl. j. health sci.

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Significant alterations are seen in hemostatic system during normal pregnancy and puerperium. Overall, it is a state of hypercoagulability and hypofibrinolysis mitigating the risk of severe bleeding during placental separation at delivery. On the flip side, it threatens a pregnant woman for thrombosis with the risk being four to six folds more in comparison to a non-pregnant woman. It is important to understand the hemostatic changes in normal pregnancy by all health care providers who manage pregnant women in obstetric wards, trauma, anesthesia and other circumstances. This review describes the changes in qualitative and quantitative changes in platelet, clotting factors, anticoagulants and fibrinolysis during normal pregnancy and puerperium.

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Beta-Thromboglobulin and Platelet Factor 4 Levels in Pregnancy and Preeclampsia

Cited by 26 publications

References 15 publications

Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre‐eclampsia

Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre‐eclampsia

The Platelet Releasate is Altered in Human Pregnancy

A Review of Hemostasis in Normal Pregnancy and Puerperium

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