Beta hydroxy beta methylbutyrate supplementation impairs peripheral insulin sensitivity in healthy sedentary Wistar rats

Abstract

The data altogether indicate that beta hydroxy beta methylbutyrate supplementation impairs insulin sensitivity in healthy sedentary rats, which, in the long-term, could lead to an increased risk of developing type 2 diabetes.

Transfer of β-hydroxy-β-methylbutyrate from sows to their offspring and its impact on muscle fiber type transformation and performance in pigs

“…1), which might be the important proof leading to the non-difference in BW of piglets at weaning. But till now it has not been demonstrated in the reduced feed intake of sows fed HMB, and research in the rat has shown that dietary HMB supplementation could impair insulin resistance and increase plasma non-essential fatty acid level [23], which could lead to the decreased feed intake during lactation, and the underlying mechanism of which remains to be explained further. However, studies have suggested that neonatal pigs have great growth potential in the immediate neonatal period, especially in terms of skeletal muscle growth, which is dependent on maternal milk intake and quality [24] and the increased milk production is associated with an increased lactation feeding level [25, 26], therefore, lower feed intake of sows during lactation might affect to some extent piglet growth in this study.…”

The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver

“…This effect was attributed mainly to glucocorticoid effect on lipolysis of adipose tissue (Geer et al 2014). In addition, HMB supplementation for 4 weeks in healthy sedentary Wistar rats reduced glucose tolerance and elevated insulin (Yonamine et al 2014). Moreover, HMB supplementation slightly D r a f t 4 increased insulin level after exercise in humans (Townsend et al 2015).…”

Keeping in synch

“…) and sometimes, interestingly, the uncritical use of food supplements (Yonamine et al . ). Factors which cannot be voluntarily influenced by the affected individual have been discussed.…”

“…Causes for obesity are numerous: unfavourable diets (Heinonen et al 2014, Brown et al 2015, lifestyle choices (R€ onn et al 2014) and sometimes, interestingly, the uncritical use of food supplements (Yonamine et al 2014). Factors which cannot be voluntarily influenced by the affected individual have been discussed.…”