Beta‐endorphin and beta‐lipotropin secretion by an acth‐secreting mouse pituitary tumor

Scherrer, H; Benjannet, Suzanne; Pezalla, Paul D.; Bourassa, Martial G.; Seidah, Nabil G.; Lis, M.; Chrétien, Michel

doi:10.1016/0014-5793(78)80403-7

Cited by 6 publications

(1 citation statement)

References 23 publications

(3 reference statements)

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“…Since our approach to elucidating the beta-LPH maturation process was mainly to characterize chemically the secretory products, we could not do it directly since the amount of common precursor is too low. However, we were able to show that ACTH-producing tumors (AtT-20 and MtT-F4) also contain beta-LPH and beta-endorphin (183,184), thus completing the analogy of their secretory material with the normal pituitary gland.…”

Section: E Beta-lph and Acth: Part Of The Same Precursormentioning

confidence: 94%

Chemistry and biosynthesis of pro-opiomelanocortin

Chrétien

Seidah

1981

Mol Cell Biochem

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Studies of lipotropins, melanotropins and endorphins on one hand, and of adrenocorticotropin on the other, has given rise to the concept of a multipotent precursor molecule recently renamed proopiomelanocortin. The preferential sites of cleavage of the precursor to produce its biologically active components are made of pairs of basic amino acid residues as described for the biosynthesis of beta-MSH and pro-insulin. Such structural feature is also found in other pro-hormone molecules. Pulse chase experiments and secretory studies carried out in both anterior and intermediate lobes of rat pituitary glands revealed the transformation of different forms of the precursor into different end-products, the anterior lobe producing preferentially ACTH and beta-LPH while the intermediate produces mainly the alpha-MSH and beta-endorphin. The multiple forms of precursors seem to differ in their carbohydrate content although at least two different gene products are still possible. The presence of similar peptides in the hypothalamus makes it highly probable that neuropeptides are biosynthesized with similar process. Thus the model of beta-LPH precursor, proposed as early as in 1967, is now applicable to the biosynthesis of all other neuropeptides. Major advances in this field are expected in the 1980s.

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Section: E Beta-lph and Acth: Part Of The Same Precursormentioning

confidence: 94%

Chemistry and biosynthesis of pro-opiomelanocortin

Chrétien

Seidah

1981

Mol Cell Biochem

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In vitro lipolytic activity of porcine β‐endorphin not mediated by an opiate receptor

Schwandt¹,

Richter²,

Wilkening³

1979

FEBS Letters

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The possibility that a component of morphine-induced analgesia is contributed indirectly via the release of endogenous opioids

Schlen

Bentley

1980

Pain

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The abdominal constriction test was used to explore the effects of cold stress (4 degrees C) of varying duration on the antinociceptive effects of morphine in mice. It was found that after 15 min exposure to cold significant endogenous analgesia was observed, together with a significant potentiation of the antinociceptive effects of morphine. However, after more prolonged exposure to 4 degrees C, the endogenous analgesia was no longer seen and, in addition, the antinociceptive effects of morphine diminished progressively, and after 2 h or longer exposure it was significantly less than control values. It was sown that, in the absence of cold stress, pretreatment with corticosterone, dexamethasone or ACTH reduced the potency of morphine in a manner similar to that seen after 4 h cold stress. It was also shown that the potency of morphine in adrenalectomized mice was not affected by 3 h cold stress. It is concluded that adrenal corticoids, released in response to the stressor effect of exposure to cold, are responsible for the antagonism of the antinociceptive action of morphine seen in mice after extended exposure to cold. It is suggested that the initial potentiation of the antinociceptive potency of morphine is due to the release of endogenous opioids. With more prolonged stress, the stores of these substances may become progressively depleted, possibly as a result of raised corticosteroid levels, so that the component of analgesia contributed by them is steadily reduced and ultimately abolished.

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Beta‐endorphin and beta‐lipotropin secretion by an acth‐secreting mouse pituitary tumor

Cited by 6 publications

References 23 publications

Chemistry and biosynthesis of pro-opiomelanocortin

Chemistry and biosynthesis of pro-opiomelanocortin

In vitro lipolytic activity of porcine β‐endorphin not mediated by an opiate receptor

The possibility that a component of morphine-induced analgesia is contributed indirectly via the release of endogenous opioids

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