“…It has been proposed that morphine may exert its lipolytic effect via a low affinity interaction with the plasma membrane adrenaline receptor (Wong, Yeung & Yeung, 1977). Recently the morphine like peptide f-endorphin has been reported to have lipolytic activity in isolated fat cells obtained from rabbits at nearly physiological concentrations (Schwandt, Richter & Wilkening, 1979). Narcotic drugs have non-specific local anaesthetic properties at high doses (Kosterlitz, Lees & Watt, 1969).…”
Section: Antagonism Of Presynaptic A2-adrenoceptors In-mentioning
thesia, measured by impedance cardiography, and the variation in response to thiopental. Acta anaesth. K12 value (r = 0.89, P < 0.001). scand., 22, 303-313.
“…It has been proposed that morphine may exert its lipolytic effect via a low affinity interaction with the plasma membrane adrenaline receptor (Wong, Yeung & Yeung, 1977). Recently the morphine like peptide f-endorphin has been reported to have lipolytic activity in isolated fat cells obtained from rabbits at nearly physiological concentrations (Schwandt, Richter & Wilkening, 1979). Narcotic drugs have non-specific local anaesthetic properties at high doses (Kosterlitz, Lees & Watt, 1969).…”
Section: Antagonism Of Presynaptic A2-adrenoceptors In-mentioning
thesia, measured by impedance cardiography, and the variation in response to thiopental. Acta anaesth. K12 value (r = 0.89, P < 0.001). scand., 22, 303-313.
Obesity as a common disorder of lipid metabolism might be caused by defective hypothalamic control as demonstrated by ventromedial lesions or the effect of cholecystokinin application. The hypothalamic proopiomelanocorticotropin is the precursor of hormonal fragments affecting fat mobilisation, the endocrine pancreas and gastrointestinal functions.
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