Beta-cyclodextrins conjugated magnetic Fe3O4 colloidal nanoclusters for the loading and release of hydrophobic molecule

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

“…50 The complete release of drugs couldn't be achieved at either pH, owing to the diffusion equilibrium between MGC/drug inclusion complexes and the released drug which would inhibit the complete drug release. 51 Furthermore, for the steric hindrance of EPI is much higher than DOX, under the same condition, more EPI will remain entrapped in the cavity of β-CD and less EPI than DOX would be released from the MGC carrier. In addition, drug release behaviors are in complete agreement with the loading amounts and the content of β-CD, suggesting that the conjugation of β-CD is conducive to the release of drug.…”

Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

“…[15] In comparison with traditional drug delivery vehicles, including polymeric micelles [16] and liposomes, [17] etc., β-CD is a good candidate as encapsulating agent for drug delivery with the advantages such as nontoxicity, stability and selective inclusion. [18] Banerjee et al [19] firstly introduced β-CD to MNPs for delivery of ketoprofen, revealing that the combination of MNPs and β-CD would generate a novel targeting delivery vehicle simultaneously with magnetic property and inclusion performance, which makes a significant breakthrough by overcoming the challenges associated with the delivery of hydrophobic drugs. Up to now, some studies have focused on constructing MNPs-β-CD nanohybrids to form new drug vectors.…”

Synthesis and in vitro evaluation of pH-sensitive magnetic nanocomposites as methotrexate delivery system for targeted cancer therapy

“…Many types of novel MTX delivery systems have been reported, such as nanoparticles [7][8][9], microspheres [10], liposomes [11], polymeric micelles [12] and miscellaneous multiparticulate systems [13]. Among these, nanoparticles, especially the magnetic iron oxide (Fe3O4) nanoparticles seem to be a promising tool for site specific delivery [14,15], based on the fact that they will release the anticancer drug on tumor cells owing to the enhanced permeability and retention (EPR) effect [16,17] and passive drug targeting. Furthermore, recently layered double hydroxide (LDH) nanoparticles have been proven effective for site-specific delivery of anticancer drugs to tumor and reduce its side effects, due to their inherent properties such as high biocompatibility [18], low cytotoxicity [19], the ability to accommodate various biologically important molecules including genes and drugs [20][21][22], and the partial dissolution of LDH layers in endosome that not only stops the passive control release of drugs, but also buffers the excess protons, which helps the drugs to escape from endosome, improves the viability of drugs in cytoplasm, and enhances the delivery efficacy [23].…”