Beta-cyclodextrin based reflective fiber-optic SPR sensor for highly-sensitive detection of cholesterol concentration

Lü, Yi; Li, Hao; Qian, Xiaolong; Zheng, Wanlu; Sun, Yang; Shi, Bufan; Zhang, Yanan

doi:10.1016/j.yofte.2020.102187

Cited by 31 publications

(9 citation statements)

References 27 publications

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“…Recent advances in fiber optics have boosted the demand for optical sensors in various fields as fiber-optic-based sensors provide various types of information by measuring the intensity, frequency, phase, and polarization of light [ 22 , 23 , 24 , 25 ]. Thus, fiber-optic sensors have been widely used in measuring physical [ 26 ] and chemical [ 27 ] quantities, especially in the monitoring of pressure [ 28 ], refractive index of analytes [ 29 ], and concentration of chemical species [ 30 ]. Fiber-optic sensors provide excellent performance in many of these applications.…”

Section: Fundamental Principles Of Fiber-optic Localized Surface Pmentioning

confidence: 99%

Fiber-Optic Localized Surface Plasmon Resonance Sensors Based on Nanomaterials

Lee

Song

Ahn

et al. 2021

Sensors

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Applying fiber-optics on surface plasmon resonance (SPR) sensors is aimed at practical usability over conventional SPR sensors. Recently, field localization techniques using nanostructures or nanoparticles have been investigated on optical fibers for further sensitivity enhancement and significant target selectivity. In this review article, we explored varied recent research approaches of fiber-optics based localized surface plasmon resonance (LSPR) sensors. The article contains interesting experimental results using fiber-optic LSPR sensors for three different application categories: (1) chemical reactions measurements, (2) physical properties measurements, and (3) biological events monitoring. In addition, novel techniques which can create synergy combined with fiber-optic LSPR sensors were introduced. The review article suggests fiber-optic LSPR sensors have lots of potential for measurements of varied targets with high sensitivity. Moreover, the previous results show that the sensitivity enhancements which can be applied with creative varied plasmonic nanomaterials make it possible to detect minute changes including quick chemical reactions and tiny molecular activities.

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Section: Fundamental Principles Of Fiber-optic Localized Surface Pmentioning

confidence: 99%

Fiber-Optic Localized Surface Plasmon Resonance Sensors Based on Nanomaterials

Lee

Song

Ahn

et al. 2021

Sensors

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“…The evanescent field of guide mode in microfiber leaks out at the tapered portion and interacts with immobilized AuNPs at the fiber surface, leading to a strong LSPR peak on the transmission spectrum. Cholesterol, the guest molecule of β-CD [108,110], is employed to validate the biosensing performance of the proposed LSPR device. The sterol groups of cholesterol molecules can tightly fit into the β-CD macrocyclic cavity, meanwhile forming stable host-guest interaction through the hydrophobic associations [111,112].…”

Section: Fiber-optic Localized Surface Plasmon Resonance Sensorsmentioning

confidence: 99%

“…* The values are mean of 4 independent experiments ± standard deviation (Reprinted with permission from reference[110]). …”

mentioning

confidence: 99%

Hybrid Plasmonic Fiber-Optic Sensors

Miao

Zhang

et al. 2020

Sensors

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With the increasing demand of achieving comprehensive perception in every aspect of life, optical fibers have shown great potential in various applications due to their highly-sensitive, highly-integrated, flexible and real-time sensing capabilities. Among various sensing mechanisms, plasmonics based fiber-optic sensors provide remarkable sensitivity benefiting from their outstanding plasmon–matter interaction. Therefore, surface plasmon resonance (SPR) and localized SPR (LSPR)-based hybrid fiber-optic sensors have captured intensive research attention. Conventionally, SPR- or LSPR-based hybrid fiber-optic sensors rely on the resonant electron oscillations of thin metallic films or metallic nanoparticles functionalized on fiber surfaces. Coupled with the new advances in functional nanomaterials as well as fiber structure design and fabrication in recent years, new solutions continue to emerge to further improve the fiber-optic plasmonic sensors’ performances in terms of sensitivity, specificity and biocompatibility. For instance, 2D materials like graphene can enhance the surface plasmon intensity at the metallic film surface due to the plasmon–matter interaction. Two-dimensional (2D) morphology of transition metal oxides can be doped with abundant free electrons to facilitate intrinsic plasmonics in visible or near-infrared frequencies, realizing exceptional field confinement and high sensitivity detection of analyte molecules. Gold nanoparticles capped with macrocyclic supramolecules show excellent selectivity to target biomolecules and ultralow limits of detection. Moreover, specially designed microstructured optical fibers are able to achieve high birefringence that can suppress the output inaccuracy induced by polarization crosstalk and meanwhile deliver promising sensitivity. This review aims to reveal and explore the frontiers of such hybrid plasmonic fiber-optic platforms in various sensing applications.

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“…Gold (Au) is more stable than any other recently known Surface Plasmon active metal and also the real part of its dielectric constant is greater yielding higher shift in the resonance parameters due to the changing refractive index [18]. The enticing features of Au allow OFBs desirable for many biosensing purposes like detection of various biomolecules in human body [19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Sensitive detection of vitamin C using etched SMS based LSPR biosensor

Uniyal

Choudhary²,

Raghuwanshi³

et al. 2023

Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII

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Ascorbic acid, genreally known as Vitamin ‘C’, is a nutrient, which is responsible for numerous biological functions like collagen formation, iron absorption, growth and repair of cells, tissues, bones, cartilages, teeth etc. It plays a promising role in providing a healthy immunity against bacterial and viral infections. It also helps in making several chemical messenger and hormones, thus playing importance in the nervopus system of body. Thus, ascorbic acid is a biomarker for the detection of various malfunctionings of the body like weakened immunity, scurvy, cardiovascular diseases, Alzheimer’s and Parkinson’s disease. In this work, a straightforward and effectual sensor model is proposed to detect the presence of ascorbic acid samples found in human body. Etched single mode fiber-multimode fiber-single mode fiber (E-SMS) is used for developing the sensor with the application of localized surface plasmon resonance (LSPR) phenomenon. For achieving LSPR and better sensitivity, the E-SMS are coated with gold nanoparticles (AuNPs). The different concentration of ascorbic acid solution alters the refractive index and the spectrum thus recorded and evaluated. The experimental results shows that the proposed E-SMS-based LSPR biosensors can detect the presence of ascorbic acid in human body and thus have significant application in the field of biosensing.

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Beta-cyclodextrin based reflective fiber-optic SPR sensor for highly-sensitive detection of cholesterol concentration

Cited by 31 publications

References 27 publications

Fiber-Optic Localized Surface Plasmon Resonance Sensors Based on Nanomaterials

Fiber-Optic Localized Surface Plasmon Resonance Sensors Based on Nanomaterials

Hybrid Plasmonic Fiber-Optic Sensors

Sensitive detection of vitamin C using etched SMS based LSPR biosensor

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