Beta-catenin expression in psoriasis

Abstract

Background:Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion. Catenins are proteins found in complexes with cadherin cell adhesion molecules of cells. The role of catenin in regulating keratinocyte stem cell differentiation and hair follicle morphogenesis has been extensively reported.Aims and Objectives:is to study β-catenin expression in lesional and non-lesional psoriatic skin to throw light upon its possible role in the pathogenesis of psoriasis.Materials and Methods:Biopsies were taken from 20 patients with psoriasis vulgaris and from 10 normal controls. The distribution of Beta catenin was investigated using polycolonal rabbits B-catenin antibody-1 by immunohistochemical method.Results:In this study membranous β-catenin expression was significantly demonstrated in the control group then the non-lesional areas in comparison to the lesional areas (P < 0.001). Nuclear β-catenin staining expression was significantly more demonstrated in lesional and non-lesional areas in comparison to the control cases (P < 0.001).Conclusions:The down regulation of membranous β-catenin expression in lesional psoriatic skin might reflect a useful phenotypic marker of hyperprolifration of keratinocytes in psoriasis. Moreover, the mild down regulation of membranous β-catenin expression in non lesional psoriatic skin may provide clues about incipient structural abnormalities in the pathogenesis of psoriasis, providing an early diagnostic indicator for evolution to a generalized form of the disease. Nuclear β-catenin expression was not found in the control group but was demonstrated in lesional and moderately in non-lesional reflecting its role in kerationcyte proliferation.

IL-36γ inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis

“…Previous studies have demonstrated membranous β-catenin expression was significantly decreased in the control group in comparison to the lesions of active psoriasis. Nuclear β-catenin expression was significantly increased in lesions of psoriasis in comparison to the control cases 13 . These suggest that β-catenin may play an important role in keratinocyte differentiation.…”

“…In a study focus on the role of β-catenin in the inhibition of epithelization and wound healing, did not find any nuclear β-catenin in normal epidermis. Decreased membrane staining and increased cytoplasm/nuclear β-catenin staining in the lesions of patients with active psoriasis have been reported 13 . The downregulation of membranous β-catenin in lesional psoriatic skin might be used as phenotypic marker of hyperprolifration of keratinocytes in psoriasis 13 , 31 .…”

“…Decreased membrane staining and increased cytoplasm/nuclear β-catenin staining in the lesions of patients with active psoriasis have been reported 13 . The downregulation of membranous β-catenin in lesional psoriatic skin might be used as phenotypic marker of hyperprolifration of keratinocytes in psoriasis 13 , 31 . Thus, to improve the related mechanisms that involved in IL-36γ-regulated differentiation and inflammation, the Wnt signaling pathway is explored in the present study, we found that Wnt signaling pathway is a crucial pathway in IL-36γ-regulated differentiation and inflammation of HaCaT cells, suggesting that IL-36γ may play a critical role in suppressing the differentiation and encouraging inflammatory response by association with Wnt signaling pathway.…”

Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs

“…It is not the case in our mouse model. Recent studies [ 30 , 31 ] have demonstrated the decreased β-catenin in the lesional skin of psoriatic patients, suggesting a reduction of cepidermal barrier effect. It should be noticed that although the downregulation of β-catenin in the upper epidermis of imiquimod-treated skin could elicit deficient barrier function, the total amount of β-catenin in epidermis might not be reduced compared to intact skin in terms of the increased number of keratinocyte layers.…”

A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia

“…Many studies suggest that vitamin D plays a role in cell differentiation and proliferation of the skin. Furthermore, cell adhesion needs cadherins, which are molecules that depend on calcium [ 5 , 21 , 22 ]. These physiologic aspects may justify how some patients with hypoparathyroidism may precipitate psoriasis, including GPP, as presented here.…”