Beta-carboline as a promising heterocyclic nucleus: Synthetic aspects, pharmacological potential and structure activity relationship

Recent developments in the total synthesis of natural products using the Ugi multicomponent reactions as the key strategy

“…The alkaloids alangiobussine (229) and alangiobussinine (230) were isolated from the leaves of Alangium bussyanum Guill., a small shrub that grows in the wet tropical forest of New Caledonia. 165 These β-carbolines bear a C-1 carboxamide motif found in many bioactive natural products, 166 and structurally similar compounds of this family have shown strong cytotoxic activity. Both natural products were synthesized by Diallo et al for comparative NMR purposes.…”

“…These β-carbolines bear a C-1 carboxamide motif found in many bioactive natural products, 166 and structurally similar compounds of this family have shown strong cytotoxic activity. Both natural products were synthesized by Diallo et al for comparative NMR purposes.…”

The Progress in Pictet‐Spengler β‐Carboline Synthesis under Green Conditions

“…The β ‐carboline scaffold is present in many biologically active compounds (Figure 2) and in some approved drugs (Figure 3). [13] The different synthetic approaches used for β ‐carboline ring preparation were previously discussed in many review articles [14–19] . However, none of them focused on the green chemical methods applied for the synthesis of this ring.…”

“…[13] The different synthetic approaches used for β-carboline ring preparation were previously discussed in many review articles. [14][15][16][17][18][19] However, none of them focused on the green chemical methods applied for the synthesis of this ring. The wide application of the β-carboline ring as previously discussed need to apply atom economical, safe, and environment-friendly methods to ensure sustainability of the synthetic procedure.…”

Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β‐Carbolines Using Diazo Compounds as Radical Precursors

“…Chiral β‐carbolines and their derivatives are widely acknowledged as remarkable and privileged scaffolds in biologically active compounds, pharmaceuticals, and natural products ( Figure 1 ) ref. [ 1 ]. The asymmetric synthesis of chiral β‐carbolines has garnered significant attention due to their unique structural features, diverse potent biological activities, and their ability to access a broad range of bio‐important molecules.…”