Recent developments in the total synthesis of natural products using the Ugi multicomponent reactions as the key strategy

Abstract

The Ugi multicomponent reaction has acquired a prominent place in modern total synthesis of natural products. Their simplicity and versatility have enabled the development of elegant, efficient, and step-economical sequences toward complex compounds.

Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years

“…This article aims to update previous reviews that covered part of the field [2] and to complement our recent publication on the use of Ugi and related MCRs for natural product synthesis. [3] Hence, the focus is placed on applying 3CR to the total syntheses of selected natural products reported in the last 15 years, emphasizing their synthetic relevance. Despite the structural diversity of the targets, they have been ordered considering the presence of heteroatoms (N, O) and the complexity of their heterocyclic rings.…”