Beta-blocking effect of propafenone based on spectral analysis of heart rate variability

Lombardi, Federico; Torzillo, Daniela; Sandrone, Giulia; Vecchia, Laura Adelaide Dalla; Finocchiaro, M. L.; Bernasconi, Roberto; Cappiello, E.

doi:10.1016/0002-9149(92)90355-3

Cited by 45 publications

(13 citation statements)

References 29 publications

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“…The LF/HF of HRV is a well-established marker of altered sympathovagal balance under a wide variety of conditions [16]. Decreased LF/HF of HRV is indicative of a change in autonomic balance toward decreased sympathetic activity [30]. Our results suggest that a low value of LF/HF of HRV may indicate a decreased capacity for activating sympathetically mediated HR and vasoconstriction mechanisms in response to hypotension, thus predisposing to the development of PRS following reperfusion.…”

Section: Discussionmentioning

confidence: 72%

Sympathetic withdrawal is associated with hypotension after hepatic reperfusion

et al. 2013

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Objective Post-reperfusion syndrome (PRS), severe hypotension after graft reperfusion during liver transplantation, is an adverse clinical event associated with poorer patient outcomes. The purpose of this study was to determine whether alterations in autonomic control in liver transplant recipients prior to graft reperfusion are associated with the subsequent development of PRS. Methods Heart rate variability (HRV), systolic arterial blood pressure (SBP) variability, and baroreflex sensitivity of 218 liver transplant recipients were evaluated using 5 min of ECG and arterial blood pressure signals 10 min before graft reperfusion along with other clinical parameters. Logistic regression analyses were performed to assess predictors of PRS occurrence. Results Seventy-seven patients (35 %) developed PRS while 141 did not. There were significant differences in SBP (110 ± 16 vs. 119 ± 16 mmHg, P \ 0.001) and the ratio of low frequency power to high frequency power (LF/ HF) of HRV (1.0 ± 1.4 vs. 2.1 ± 3.7, P = 0.003) between the PRS group and No-PRS group. In multivariate logistic regression analysis, predictors were LF/HF (odds ratio 0.817, P = 0.028) and SBP (odds ratio 0.966, P \ 0.001).Interpretation Low LF/HF and SBP measured before hepatic graft reperfusion were significantly correlated with subsequent PRS occurrence, suggesting that sympathovagal imbalance and depressed SBP may be key factors predisposing to reperfusion-related severe hypotension in liver transplant recipients.

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Section: Discussionmentioning

confidence: 72%

Sympathetic withdrawal is associated with hypotension after hepatic reperfusion

et al. 2013

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“…A triplet of ventricular extrasystoles was detected in one patient whereas long-term ECG registration using the Holter method showed that the overall incidence of ventricular premature beats decreased during cinchonine perfusion. Frequential analysis indicated that control of the heart rate by the sympathetic nervous system was reduced by cinchonine, an effect observed with the class Ic anti-arrhythmic propafenone, 49 but did not significantly affect the sympathetico-vagal balance. 50,51 This may explain the absence of 'torsade de pointes' whose occurrence has been shown to require a low stimulation frequency.…”

Section: Discussionmentioning

confidence: 93%

Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lymphoproliferative syndromes

Solary

Mannone²,

Moreau³

et al. 2000

Leukemia

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“…The low/high frequency component ratio has been used as an index of the sympathovagal balance to the heart. 2,13,14) An increased LF / HF ratio suggests increased sympathetic or decreased parasympathetic drive to the heart and vice versa. The balance among the two opposing elements of the autonomic nervous system alters and concomitantly reflects the pathophysiologic state of cardiac performance.…”

Section: Discussionmentioning

confidence: 99%

Modulation of the Sympathovagal Balance in Drug Refractory Dilated Cardiomyopathy, Treated with Permanent Atrioventricular Sequential Pacing.

et al. 2000

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SUMMARYThe aim of this study was to assess the long term efficacy of DDD pacing mode in selected patients with idiopathic dilated cardiomyopathy (IDCM) and drug refractory heart failure. The patients were evaluated according to the long term alteration of the sympathovagal balance (SVB). Patients with IDCM were considered eligible for DDD pacing if during temporary VDD pacing a 15% or more increase in the resting cardiac output was demonstrated. From the 29 patients studied, finally 20 patients (15M, 5F, 69 ± 10 years) fulfilled the aforementioned criterion and therefore were considered candidates for permanent DDD pacing (NYHA class: 3.5 ± 0.3, Ejection fraction : 27 ± 7%, Resting cardiac index (CI) 2.6 ± 0.4 l / min). The ECG of the patients demonstrated LBBB in 13, RBBB in 4 and RBBB + LAH in 3, with a PR interval of 232 ± 28 ms and QRS duration of 138 ± 15ms. The pacemaker was programmed at 40-150 bpm, and AV delay of 105 ± 20 ms. The lower heart rate programmed, in conjunction with the heart failure state of these patients, was responsible for essentially continuous atrial tracking, ventricular pacing. We evaluated the SVB in the pre-and post-implant periods (3rd and 6th month), using the hourly power spectral analysis (PSA) of heart rate variability during 24 hour Holter monitoring. As SVB we considered the ratio: low (0.04 -0.15 Hz) to high frequency (0.15 -0.40 Hz). We compared the SVB (LF / HF) during the day and night time for the pre-and post-implant periods. Post-pacing, the NYHA class was significantly improved (2.9 ± 0.2 and 2.7 ± 0.3 the 3rd and 6th month respectively). The mean heart rate was 78 ± 8 bpm in the 3rd and 80 ± 7 bpm in the 6th month postoperatively, which was lower than the 84 ± 9 bpm preoperatively, but this difference did not reach statistical significance. During

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Beta-blocking effect of propafenone based on spectral analysis of heart rate variability

Cited by 45 publications

References 29 publications

Sympathetic withdrawal is associated with hypotension after hepatic reperfusion

Sympathetic withdrawal is associated with hypotension after hepatic reperfusion

Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lymphoproliferative syndromes

Modulation of the Sympathovagal Balance in Drug Refractory Dilated Cardiomyopathy, Treated with Permanent Atrioventricular Sequential Pacing.

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