Beta-Blockers in Treatment of Theophylline Overdose

Farrar, Keith; Dunn, A.M.

doi:10.1016/s0140-6736(85)91754-4

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…Experiments showed that theophylline (or its metabolites) could stimulate cholinergic effect [ 28 ]. Beta-adrenergic blockers may also interfere the effects of theophylline if they are taken together [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Characterization of the mechanism of drug-drug interactions from PubMed using MeSH terms

et al. 2017

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Identifying drug-drug interaction (DDI) is an important topic for the development of safe pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases such as cancer and HIV. There have been about 150,000 publications on DDIs in PubMed, which is a great resource for DDI studies. In this paper, we introduced an automatic computational method for the systematic analysis of the mechanism of DDIs using MeSH (Medical Subject Headings) terms from PubMed literature. MeSH term is a controlled vocabulary thesaurus developed by the National Library of Medicine for indexing and annotating articles. Our method can effectively identify DDI-relevant MeSH terms such as drugs, proteins and phenomena with high accuracy. The connections among these MeSH terms were investigated by using co-occurrence heatmaps and social network analysis. Our approach can be used to visualize relationships of DDI terms, which has the potential to help users better understand DDIs. As the volume of PubMed records increases, our method for automatic analysis of DDIs from the PubMed database will become more accurate.

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Section: Resultsmentioning

confidence: 99%

Characterization of the mechanism of drug-drug interactions from PubMed using MeSH terms

et al. 2017

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“…Since coronary artery spasm may be an initiating event in myocardial infarction,'3 we suggest that in patients whodevelopcardiotoxicityassociatedwithfluorouracil further treatment if necessary should be accompanied by vasodilator therapy. 3 Kaye SB, Ikram H. Acute cardiac pain and electrocardiographic changes following cytotoxic treatment for metastatic carcinoma. Clin Oncol 1976;2:215-8.…”

Section: Drug Pointsmentioning

confidence: 99%