Hypothyroidism after treatment with ketoconazole.

Chronic mucocutaneous candidosis (CMC) is a rare, complex disorder characterized by chronic and recurrent candida infections of the skin, nails and oropharynx. In over 50% of cases there is an associated endocrine disease, the complex being described as the candida endocrinopathy syndrome. Inheritance of familial endocrine associated cases has been thought to follow an autosomal recessive pattern. In addition, autosomal recessive and autosomal dominant forms of CMC not associated with endocrinopathy have been described. We report a new syndrome in which there is vertical transmission of CMC within families associated with primary hypothyroidism. This suggests that the candida endocrinopathy syndrome can be subdivided into at least two types, one associated with hypoparathyroidism and/or hypoadrenalism which is inherited as an autosomal recessive trait, the other associated with hypothyroidism which is an autosomal dominant disease. We emphasize the importance of early and regular monitoring thyroid function in individuals with CMC and a need to provide appropriate genetic counselling to affected members.

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Chronic mucocutaneous candidosis associated with hypothyroidism: a distinct syndrome?

Coleman¹,

Hay²

1997

Br J Dermatol

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Hypothyroidism after treatment with ketoconazole.

Cited by 3 publications

References 2 publications

Endocrine Complications of the Acquired Immunodeficiency Syndrome

Endocrine Complications of the Acquired Immunodeficiency Syndrome

Chronic mucocutaneous candidosis associated with hypothyroidism: a distinct syndrome?

Chronic mucocutaneous candidosis associated with hypothyroidism: a distinct syndrome?

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