Bestimmung von Kurzschlu�durchblutung und Diffusionskapazit�t der Lunge bei Gesunden und Lungenkranken

Bartels, H.; Beer, Ronny; Fleischer, E.; Hoffheinz, H. J.; Krall, John M.; Rodewald, G.; Wenner, J; Witt, I.

doi:10.1007/bf00369783

Cited by 101 publications

(13 citation statements)

References 59 publications

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“…Cardiac output studies were not performed on subject IV-2, but other parameters were within normal limits (Table III). Mixed venous oxygen pressures of 34-35 mm Hg were somewhat lower than the 39-40 mm Hg reported for normal subjects under comparable circumstances (12). A decreased intercapillary diffusion distance in the tissues would allow adequate oxygen supply at lower than normal mean capillary Po2, but no studies of tissue capillarity were performed.…”

Section: Resultsmentioning

confidence: 68%

Hemoglobin Yakima: II. High Blood Oxygen Affinity Associated with Compensatory Erythrocytosis and Normal Hemodynamics*

Novy¹,

Edwards²,

Metcalfe³

1967

J. Clin. Invest.

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Abstract. Erythrocytosis without clinical illness was noted in a man and his two daughters. Their blood contained approximately 62% hemoglobin A and 38% a new hemoglobin, designated hemoglobin Yakima. The oxygen affinity of whole blood from each subject was greatly increased and hemeheme interactions were impaired. At 370C and a plasma pH of 7.40, the oxygen pressure required to produce 50% saturation of hemoglobin with oxygen was only 12 mm Hg as compared with a normal of 26 mm Hg. The high oxygen affinity of this blood is attributed to the presence of hemoglobin Yakima; and the increased oxygen affinity was shown to be characteristic of the isolated abnormal hemoglobin. A Bohr effect was present in hemoglobin Yakima.Arterial oxygen pressure, oxygen consumption, and cardiac output at rest were normal. With respect to oxygen delivery to tissues, the increased hemoglobin concentration appears to be the major compensation for the marked displacement of the oxygen-hemoglobin equilibrium curve, although other factors may contribute. The finding of high normal quantities of erythropoietin in the urine is consistent with this degree of erythrocytosis.

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Section: Resultsmentioning

confidence: 68%

Hemoglobin Yakima: II. High Blood Oxygen Affinity Associated with Compensatory Erythrocytosis and Normal Hemodynamics*

Novy¹,

Edwards²,

Metcalfe³

1967

J. Clin. Invest.

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“…Bartels et al, 1955;Dripps and Comroe, 1947;Hemingway and Nahas, 1952]. In the first few minutes of hypoxia there is thus evidence of more exaggerated chemoreceptor effects on the circulation and respiration of the rabbit, than in man or the dog.…”

Section: Discussionmentioning

confidence: 99%

The Immediate‐effects of Acute Hypoxia on the Heart Rate, Arterial Pressure, Cardiac Output and Ventilation of the Unanæsthetized Rabbit

Edwards

1960

Exp Physiol

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The circulatory and respiratory changes occurring during the first 5 min. of hypoxia were studied in unanawsthetized rabbits. Mild degrees of hypoxia produced an increase in ventilation in the rabbit, without eliciting a detectable circulatory response. The early circulatory effects consisted of bradycardia, a rise in mean arterial pressure and a fall in cardiac output, indicating predominant systemic vasoconstriction. The magnitude of the bradyeardia and rise in arterial pressure were related to the fall in arterial 02 saturation. Atropine or vagotomy reduced or abolished the bradycardia, but greatly accentuated the rise in blood pressure. Denervation of the carotid baroreceptors and chemoreceptors almost abolished the bradyeardia and diminished the rise in blood pressure.IN the first few minutes after induction of acute hypoxia most mammalian species develop tachycardia, a moderate rise in mean arterial pressure and an increase in ventilation. It is generally agreed that the role of the arterial chemoreceptors is of paramount importance in the early respiratory drive during oxygen lack [Bjurstedt, 1946;Otis, 1947 and1949]. Up till recently the tachycardia which develops in the early phase of hypoxia has also been considered to be of chemoreceptor origin. Recent observations in dogs on the effects of stimulation of the arterial chemoreceptors by perfusion with venous blood cast considerable doubt on this interpretation, since these procedures usually produce bradyeardia [Bernthal, Greene and Revzin, 1951; Neil, 1956;Scott, 1958 and.The unanaesthetized rabbit develops during the first few minutes of hypoxia a pronounced bradycardia rather than the usual tachyeardia and some rise in arterial pressure. The purpose of this paper is to report the results of an analysis of the mechanism of this early circulatory response to acute hypoxia. METHODSUnanaesthetized rabbits were used in these experiments, except when otherwise stated. The operative techniques were carried out under local anaesthesia and included tracheotomy, central ear artery cannulation and right atrial catheterization

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“…Hemoglobin Hirose corresponds to the former case (Fig. 3), and under physiological conditions, that is, above 75% oxygen saturation of blood (46) (47,48). Hemoglobin A has higher oxygen affinity than hemoglobin F, but in the presence of DPG, the comparative oxygen affinities are reversed (49).…”

Section: Resultsmentioning

confidence: 88%

Oxygen Equilibrium Characteristics of Abnormal Hemoglobins: Hirose (α2β237Ser), L Ferrara (α247Glyβ2), Broussais (α290Asnβ2), and Dhofar (α2β258Arg)

Fujita¹

1972

J. Clin. Invest.

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A BS T R A C T The oxygen equilibrium characteristics of four structural variants of hemoglobin A were correlated with their amino acid substitutions.Hemoglobin Dhofar, in which the proline at E2 (58)9 is replaced by arginine, had normiial oxygen equilibrium characteristics.Hemoglobin L Ferrara, in which the aspartic acid at CD5 (47)a is replaced by glycine, and hemoglobin Broussais, in which the lvsine at FG2(90)a is replaced by asparagine, both showed a slightly elevated oxygen affinity; nevertheless both demonstrated a normal hemeheme interaction and a normal Bohr effect.Hemoglobin Hirose, in which the tryptophan at C3 (37),3 is replaced by serine, showed abnormalities of all oxygen equilibrium characteristics; i.e., increased oxygen affinity, diminished heme-heme interaction, and reduced Bohr effect.These results suggest that aspartic acid at CD5(47)a and lysine at FG2 (90) Tryptophan at C3 (37)13 is located at contact betwveen al-and /32-subunits. It is suggested that the substitution by serine might disturb the quarternary structure of the mutant hemoglobin molecule during transition from oxy-form to deoxy-form resulting in an alteration of the heme function.

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Bestimmung von Kurzschlu�durchblutung und Diffusionskapazit�t der Lunge bei Gesunden und Lungenkranken

Cited by 101 publications

References 59 publications

Hemoglobin Yakima: II. High Blood Oxygen Affinity Associated with Compensatory Erythrocytosis and Normal Hemodynamics*

Hemoglobin Yakima: II. High Blood Oxygen Affinity Associated with Compensatory Erythrocytosis and Normal Hemodynamics*

The Immediate‐effects of Acute Hypoxia on the Heart Rate, Arterial Pressure, Cardiac Output and Ventilation of the Unanæsthetized Rabbit

Oxygen Equilibrium Characteristics of Abnormal Hemoglobins: Hirose (α2β237Ser), L Ferrara (α247Glyβ2), Broussais (α290Asnβ2), and Dhofar (α2β258Arg)

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