Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters

Rouanet, Jean-Max; Décordé, Kelly; Rio, Daniele Del; Auger, Cyril; Borges, Gina; Cristol, Jean‐Paul; Lean, Michael E. J.; Crozier, Alan

doi:10.1016/j.foodchem.2009.04.116

Cited by 58 publications

(47 citation statements)

References 29 publications

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“…These berries are thought to be related with many health benefits for humans, including eye protection, antioxidation, cardioprotection, antiinflammatory, hypoglycemic, and antimicrobial effects (Chu et al 2011;Dinkova et al 2014). They also contain a vast number of other phytochemicals for which there are no known deficiency conditions but which may have marked bioactivities in mammalian cells of potential health benefit (Tumbas Šaponjac et al 2015;Beattie et al 2005;Rouanet et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Extraction of Copper Complexes with Phenolic Compounds from Açaí (Euterpe oleracea Mart.) and Bilberry (Vaccinium myrtillus L.) Fruits

Wojcieszek

Ruzik

2016

Food Anal. Methods

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In this study, an analytical procedure for the extraction of phenolic copper complexes from two species of berries-Brazilian açaí (Euterpe oleracea Mart.) and Polish bilberry (Vaccinium myrtillus L.)-has been performed. Berries have proven to be a good source of vitamins and various nutrients, especially compounds with antioxidant capacity such as polyphenols, tocopherols, and ascorbic acid. Polyphenols from plant/foods interact strongly with cations (copper), and the experimental evidence presented in literature shows that the antioxidant activity is modified by the presence of metal ions. To obtain the information about phenolic copper complex attendance in berries, the enzymatic treatment with pectinase and hemicellulase was performed. These enzymes cause degradation of the cell wall matrix, causing enhancing to the extraction yield. Berries were treated with buffer (ammonium acetate) and enzymatic extraction (pectinase and hemicellulase) media and analyzed by size exclusion chromatography coupled to a mass spectrometer with inductively coupled plasma (SEC-ICP-MS) and an on-capillary liquid chromatograph coupled to an electrospray tandem mass spectrometer (μ-HPLC-ESI-MS/MS) techniques. The enzymatic treatment process significantly increases the extraction and helps extraction of other groups of copper complexes with polyphenols-such as those known from the literature and new one. In berries, copper is complexed by flavonols, for example, quercetin; flavanone, for example luteolin; and hydroxybenzoic acid, for example, syringic acid. We could indicate that in açaí and bilberry copper is complexed by non-cellwall phenols and, additionally, in bilberry by cell wall phenols.The six copper complexes with polyphenol presence in berries are presented in the table of this work.

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Section: Introductionmentioning

confidence: 99%

Enzymatic Extraction of Copper Complexes with Phenolic Compounds from Açaí (Euterpe oleracea Mart.) and Bilberry (Vaccinium myrtillus L.) Fruits

Wojcieszek

Ruzik

2016

Food Anal. Methods

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“…There is evidence from a diversity of sources that a berry-rich diet offers potential protective effects on health (Beattie et al, 2005;Del Rio et al, 2010) with daily consumption of red raspberry juice for 12 weeks by hamsters consuming an atherogenic diet reducing aortic lipid deposition by ϳ90% (Rouanet et al, 2010). Red raspberries contain the ellagitannins sanguiin H-6 and lambertianin C as well as a characteristic spectrum of anthocyanins, the major constituents being cyanidin-3-O-sophoroside, cyanidin-3-O-(2Љ-O-glucosyl)rutinoside, and cyanidin-3-O-glucoside with smaller quantities of cyanidin-3-O-rutinoside, cyanidin-3-O-(2Љ-Oxylosyl)rutinoside pelargonidin-3-O-sophoroside, pelargonidin-3-(2Љ-O-glucosyl)rutinoside, pelargonidin-3-O-glucoside, and pelargonidin-3-O-rutinoside (Mullen et al, 2002;Borges et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Colonic Catabolism of Ellagitannins, Ellagic Acid, and Raspberry Anthocyanins: In Vivo and In Vitro Studies

González‐Barrio

Edwards²,

Crozier³

2011

Drug Metab Dispos

Self Cite

170

157

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ABSTRACT:Red raspberries contain principally anthocyanins and ellagitannins. After ingestion of raspberries by humans, trace levels of anthocyanins, absorbed in the upper gastrointestinal tract, are excreted in urine in amounts corresponding to <0.1% of intake. Urine also contains urolithin-O-glucuronides derived from colonic metabolism of the ellagitannins. Raspberry feedings with ileostomists show that substantial amounts of the anthocyanin and ellagitannin intake are excreted in ileal fluid. In subjects with an intact functioning colon, these compounds would pass to the large intestine. The aim of this study was to identify raspberry-derived phenolic acid catabolites that form in the colon and those that are subsequently excreted in urine. In vitro anaerobic incubation of ellagitannins with fecal suspensions demonstrated conversion to ellagic acid and several urolithins. Fecal suspensions converted 80% of added ellagic acid to urolithins. In vivo, urolithins are excreted in urine as O-glucuronides, not aglycones, indicating that the colonic microflora convert ellagitannins to urolithins, whereas glucuronidation occurs in the wall of the large intestine and/or postabsorption in the liver. Unlike ellagitannins, raspberry anthocyanins were converted in vitro to phenolic acids by anaerobic fecal suspensions. Urinary excretion of phenolic acids after ingestion of raspberries indicates that after formation in the colon some phenolic acids undergo phase II metabolism, resulting in the formation of products that do not accumulate when anthocyanins are degraded in fecal suspensions. There is a growing realization that colonic catabolites such as phenolic acids and urolithins may have important roles in the protective effects of a fruit-and vegetablerich diet.

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“…Phenolic compounds from red raspberries show strong antimicrobial properties and can selectively inhibit the growth of intestinal pathogens, especially Staphylococcus strains (Puupponen-Pimiä et al, 2005). Consumption of red raspberry juice has been shown to lead to a marked reduction in aortic lipid deposition, which can help to prevent the development of early atherosclerosis (Suh et al, 2011;Rouanet et al, 2010). Red raspberry juice may also have beneficial effects against several types of human cancers, which is attributed to its ability to reduce damage resulting from oxidative stress and inflammation (Seeram, 2008;Zafra-Stone et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Clarification of red raspberry juice using microfiltration with gas backwashing: A viable strategy to maximize permeate flux and minimize a loss of anthocyanins

Vladisavljević

Vukosavljević

Veljović

2013

Food and Bioproducts Processing

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Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters

Cited by 58 publications

References 29 publications

Enzymatic Extraction of Copper Complexes with Phenolic Compounds from Açaí (Euterpe oleracea Mart.) and Bilberry (Vaccinium myrtillus L.) Fruits

Enzymatic Extraction of Copper Complexes with Phenolic Compounds from Açaí (Euterpe oleracea Mart.) and Bilberry (Vaccinium myrtillus L.) Fruits

Colonic Catabolism of Ellagitannins, Ellagic Acid, and Raspberry Anthocyanins: In Vivo and In Vitro Studies

Clarification of red raspberry juice using microfiltration with gas backwashing: A viable strategy to maximize permeate flux and minimize a loss of anthocyanins

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