Bergmann glial cells in situ express endothelinB receptors linked to cytoplasmic calcium signals

Tuschick, Sebastian; Kirischuk, Sergei; Kirchhoff, Frank; Liefeldt, Lutz; Paul, Martin; Verkhratsky, Alexei; Kettenmann, Helmut

doi:10.1016/s0143-4160(97)90052-x

Cited by 47 publications

(24 citation statements)

References 28 publications

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“…After termination of the stimulus, [CaZ § decreased below the initial equilibrium value. Such dynamics of [Ca 2 § ] resembled the experimental data [2,7].…”

Section: +supporting

confidence: 75%

“…Local dynamics of Ca z § concentration in the cytoplasm, [Ca It, and resting Ca 2+ concentration in the cytoplasm [1,2] resting Ca 2+ concentration in the store effective thickness of the submemhrane layer volume-to-area ratio in the intracellular store dimensional coefficient efficiency of Ca2+/Na + exchanger efficiency of ATP-driven Ca z+ pump of the plasma membrane efficiency of ATP-driven pump of the endoplasmic reticulum…”

Section: Description Of the Model Of Calcium Dynamics In A Glial Cellmentioning

confidence: 99%

“…A close morphological linkage is a prerequisite for the functional neuro-glial interaction [1]. Such an interaction can influence accumulation and release of neuroactive substances, permeability of ion channels, and concentration of ions, particularly calcium, in the neurons [2 ]. An important role in calcium dynamics is attributed to the intracellular stores.…”

Section: Introductionmentioning

confidence: 99%

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Calcium dynamics in a bergmann glial cell during metabotropic activation: a simulation study

1998

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A mathematical model of calcium dynamic~ in a Bergmann cell of the cerebellum is proposed. The model adequately describes the experimentally observed behavior of the prototype, Including the shape and time-~le of Ca 2+ responses to single and repetitive metabotropic stimuli and the changes of Ca 2+ transient~ caused by Inhibition of Ca 2+ uptake into the store. By means of the model, the role of calcium pumps in regulating the cytoplasmic Ca 2+ concentration is studied. It is found that the store dimension evaluated by stimulation has the order of magnitude of tens of nanometers, and the Ca 2+ concentration in the store is about 10 pM.

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“…After termination of the stimulus, [CaZ § decreased below the initial equilibrium value. Such dynamics of [Ca 2 § ] resembled the experimental data [2,7].…”

Section: +supporting

confidence: 75%

Section: Description Of the Model Of Calcium Dynamics In A Glial Cellmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Calcium dynamics in a bergmann glial cell during metabotropic activation: a simulation study

1998

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“…Two types of endothelin receptors, the ET A and ET B , were discovered in neural cells; the stimulation of these receptors triggers Ca 2ϩ mobilization via InsP 3 -induced intracellular Ca 2ϩ release (621,811,937 (573).…”

Section: Endothelin Receptorsmentioning

confidence: 99%

Physiology of Microglia

Kettenmann

Hanisch

Нода

et al. 2011

Physiological Reviews

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3,100

2,981

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Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed “resting microglia.” Recent studies indicate that even in the normal brain, microglia have highly motile processes by which they scan their territorial domains. By a large number of signaling pathways they can communicate with macroglial cells and neurons and with cells of the immune system. Likewise, microglial cells express receptors classically described for brain-specific communication such as neurotransmitter receptors and those first discovered as immune cell-specific such as for cytokines. Microglial cells are considered the most susceptible sensors of brain pathology. Upon any detection of signs for brain lesions or nervous system dysfunction, microglial cells undergo a complex, multistage activation process that converts them into the “activated microglial cell.” This cell form has the capacity to release a large number of substances that can act detrimental or beneficial for the surrounding cells. Activated microglial cells can migrate to the site of injury, proliferate, and phagocytose cells and cellular compartments.

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“…That is, investigations of Bergmann glial cells (BG) in cerebellar slices revealed a particular organization of Ca 2+ signals, probably associated with intracellular Ca 2+ release. BGs are endowed with a specific set of metabotropic neurotransmitter receptors (mGluRs, adreno-, purino-and histamine metabotropic receptors as well as endothelin receptors -see [13,15,16,17,24]), which are all coupled with Ca 2+ release from the ER store. Electrical stimulation of parallel fibres evokes highly localized [Ca 2+ ] i elevations in small compartments within BG processes [10].…”

Section: Introductionmentioning

confidence: 99%

Theoretical estimation of the capacity of intracellular calcium stores in the Bergmann glial cell

Kiryushko

Savtchenko

Verkhratsky

et al. 2001

Pflügers Arch - Eur J Physiol

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We propose a mathematical model for calcium dynamics ([Ca2+]i) during metabotropic activation of a specialized astrocyte, the cerebellar Bergmann glial cell. The model adequately describes the experimentally observed behaviour of the prototype in response to single and repetitive metabotropic stimuli and to the inhibition of Ca2+ uptake into the store. By means of the model, the capacity of the intracellular calcium store for two types of calcium buffer was estimated. The estimated buffer capacity of the store lies within the following intervals: (0.8-15.5).10-19 mol calmodulin, and (0.6-12.3).10-19 mol calbindin. This result reveals, that, in the store of a small Ca2+-containing compartment optically detected in the Bergmann glial cell process after electrical stimulation of parallel fibres, the amount of releasable Ca2+ does not exceed 25,000 ions. The quantitative estimates were obtained from experimentally based theoretical relationships between the capacity and volume of the store and parameters of the cytoplasmic calcium buffer. In these relationships, the estimated store capacity was proportional to the total buffer concentration, inversely proportional to the constant of buffer affinity for calcium and was smaller for a greater relative store volume.

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Bergmann glial cells in situ express endothelinB receptors linked to cytoplasmic calcium signals

Cited by 47 publications

References 28 publications

Calcium dynamics in a bergmann glial cell during metabotropic activation: a simulation study

Calcium dynamics in a bergmann glial cell during metabotropic activation: a simulation study

Physiology of Microglia

Theoretical estimation of the capacity of intracellular calcium stores in the Bergmann glial cell

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