Calcium dynamics in a bergmann glial cell during metabotropic activation: a simulation study

Abstract

A mathematical model of calcium dynamic~ in a Bergmann cell of the cerebellum is proposed. The model adequately describes the experimentally observed behavior of the prototype, Including the shape and time-~le of Ca 2+ responses to single and repetitive metabotropic stimuli and the changes of Ca 2+ transient~ caused by Inhibition of Ca 2+ uptake into the store. By means of the model, the role of calcium pumps in regulating the cytoplasmic Ca 2+ concentration is studied. It is found that the store dimension evaluated by stimulation has the order of magnitude of tens of nanometers, and the Ca 2+ concentration in the store is about 10 pM.