Bergenia ciliata as a future candidate for liver diseases: a concise review

Latief, Uzma; Tung, Gurleen Kaur; Singh, Harjeet; Per, Tasir S.; Jain, Subheet Kumar

doi:10.1186/s41936-022-00282-x

Cited by 3 publications

(2 citation statements)

References 82 publications

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“…The plant B. ciliata has long been utilised as a medication for the treatment of various human illnesses. Many rural tribes in the Himalayan region utilize B. ciliata to treat various ailments (17) . The rhizome of B. ciliata has been used for centuries to treat lung infections, piles, leucorrhoea, and to dissolve bladder as well as kidney stones (18) .…”

Section: Social Interaction Methodsmentioning

confidence: 99%

Evaluation of Anxiolytic Activity of Methanolic Extract of Rhizome of Bergenia ciliata (Pashanbheda) in Swiss Albino Mice

Rachana,

Jyothi,

Deekshitha

et al. 2023

IJST

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Objectives:To evaluate the possible anxiolytic activity of methanolic extract of Bergenia ciliata rhizome (MEBC) in Swiss albino mice. Methods: The methanolic extract of the rhizome of Bergenia ciliata was tested on various conventional animal models, such as the elevated plus maze, staircase, social interaction, and light/dark model. MEBC with 200mg/kg & 400mg/kg dose in 1% of carboxy methyl cellulose, diazepam with 2mg/kg dose,1% of Carboxy Methyl Cellulose was used as vehicle control in the study. Findings: In the Elevated plus maze model, the numbers of entries in the open arm were 3.1±0.57, 14.5±1.02, 10.8±1.07, and 7.57±0.63 respectively noted for vehicle control, Diazepam (2mg/ml), 200 and 400 mg/kg of MEBC. Similarly, in the Light-dark arena model, the numbers of entries in the dark chamber were 223. 67±0.11.59, 102.33±32.893, 188.33±28.992, and 192±25.120, respectively noted for vehicle control, Diazepam (2mg/ml), 200 and 400 mg/kg of MEBC. In the staircase exploration model, the number of steps climbed were 8.61 ± 2.21, 23.41 ± 1.34, 20.32 ± 1.06 and 11.69 ± 1.94 respectively for vehicle control, Diazepam (2mg/ml), 200 and 400 mg/kg of MEBC. In staircase exploration model and social interaction models, MEBC treated group with a low dose (200 mg/kg) revealed a statistically significant (P<0.05) increase in rearing and social contact. This result clearly showed that MEBC-200mg/KG has antianxiety properties when compared to diazepam. Novelty: Bergenia ciliata may prove to be a useful source of natural psychotherapy agents to treat a range of illnesses associated with anxiety.

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Section: Social Interaction Methodsmentioning

confidence: 99%

Evaluation of Anxiolytic Activity of Methanolic Extract of Rhizome of Bergenia ciliata (Pashanbheda) in Swiss Albino Mice

Rachana,

Jyothi,

Deekshitha

et al. 2023

IJST

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“…Searching for new natural compounds as alternative medicine effective against liver injury has gained more attention from researchers in recent years due to the drawbacks related to chemically synthetic drugs [23,24]. Thus, scientists have explored and shown the therapeutic efficacy of numerous plant-based compounds including SA against many health issues (renal, liver, diabetic, and heart diseases) [10,12,14].…”

Section: Introductionmentioning

confidence: 99%

Sinapic Acid Attenuate Liver Injury by Modulating Antioxidant Activity and Inflammatory Cytokines in Thioacetamide-Induced Liver Cirrhosis in Rats

Jabbar,

Alamri,

Abdulla

et al. 2023

Biomedicines

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Sinapic acid (SA) is a natural pharmacological active compound found in berries, nuts, and cereals. The current study aimed to investigate the protective effects of SA against thioacetamide (TAA) fibrosis in rats by histopathological and immunohistochemical assays. The albino rats (30) were randomly divided into five groups (G). G1 was injected with distilled water 3 times/week and fed orally daily with 10% Tween 20 for two months. G2–5 were injected with 200 mg/kg TAA three times weekly for two months and fed with 10% Tween 20, 50 mg/kg silymarin, 20, and 40 mg/kg of SA daily for 2 months, respectively. The results showed that rats treated with SA had fewer hepatocyte injuries with lower liver index (serum bilirubin, total protein, albumin, and liver enzymes (ALP, ALT, and AST) and were similar to that of control and silymarin-treated rats. Acute toxicity for 2 and 4 g/kg SA showed to be safe without any toxic signs in treated rats. Macroscopic examination showed that hepatotoxic liver had an irregular, rough surface with micro and macro nodules and histopathology expressed by Hematoxylin and Eosin, and Masson Trichrome revealed severe inflammation and infiltration of focal necrosis, fibrosis, lymphocytes, and proliferation bile duct. In contrast, rats fed with SA had significantly lower TAA toxicity in gross and histology and liver tissues as presented by less liver tissue disruption, lesser fibrosis, and minimum in filtered hepatocytes. Immunohistochemistry of rats receiving SA showed significant up-regulation of HSP 70% and down-regulation of alpha-smooth muscle actin (α-SMA) protein expression compared to positive control rats. The homogenized liver tissues showed a notable rise in the antioxidant enzymes (SOD and CAT) actions with significantly lower malondialdehyde (MDA) levels compared to that of the positive control group. Furthermore, the SA-treated rats had significantly lower TNF-a, IL-6, and higher IL-10 levels than the positive control rats. Thus, the findings suggest SA as a hepatoprotective compound due to its inhibitory effects on fibrosis, hepatotoxicity, liver cell proliferation, up-regulation of HSP 70, and downregulation of α-SMA expression, inhibiting lipid peroxidation (MDA), while retaining the liver index and antioxidant enzymes to normal.

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Oxidative Medicine and Novel Pharmacological Treatment Approaches in Liver Disease

Tripathi,

Singh,

Mourya

et al. 2023

Adaptation Under Stressful Environments Through Biological Adjustments and Interventions

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Bergenia ciliata as a future candidate for liver diseases: a concise review

Cited by 3 publications

References 82 publications

Evaluation of Anxiolytic Activity of Methanolic Extract of Rhizome of Bergenia ciliata (Pashanbheda) in Swiss Albino Mice

Evaluation of Anxiolytic Activity of Methanolic Extract of Rhizome of Bergenia ciliata (Pashanbheda) in Swiss Albino Mice

Sinapic Acid Attenuate Liver Injury by Modulating Antioxidant Activity and Inflammatory Cytokines in Thioacetamide-Induced Liver Cirrhosis in Rats

Oxidative Medicine and Novel Pharmacological Treatment Approaches in Liver Disease

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