Bergenia ciliata: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety

Ahmad, Mushtaq; Butt, Maryam Akram; Zhang, Guolin; Sultana, Shazia; Tariq, Akash; Zafar, Muhammad

doi:10.1016/j.biopha.2017.10.141

Cited by 64 publications

(33 citation statements)

References 95 publications

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“…Foeniculum vulgare has been extensively utilized in traditional medicine for the treatment of a wide range of diseases. Although the previous studies indicated estragole genotoxicity and hepatocarcinogenicity of Foeniculum vulgare in mice, no DNA damage caused by this medical plant was found in human hepatic cells ( 18 – 21 ). The available scientific study has suggested that it is a critical medical plant for the management of arthritis, cancer, diarrhea, constipation, fever, gastritis, and stomachache ( 22 – 30 ).…”

Section: Discussionmentioning

confidence: 68%

A 90-Day Oral Toxicity Study of the Ethanol Extract from Eupatorium japonicum Thunb and Foeniculum vulgare in Rats

Dai

Wang

Tang

et al. 2020

BioMed Research International

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Eupatorium japonicum Thunb and Foeniculum vulgare are two of the most widely used folk herbs and constituents in many traditional Chinese herbal formulas. Nonetheless, little toxicological and safety information associated with following daily repeated exposure is obtained according to previous research. The present study was performed to assess the toxicity of ethanol extract from Eupatorium japonicum Thunb and Foeniculum vulgare (EFE) in male rats administered by dietary oral gavage at target doses of 0.39, 0.78, and 1.56 g/kg body weight/day for 90 days. There were no significant adverse effects on clinical signs, body weight, food conversion efficiency, and vital hematological indices. However, some hematology and biochemical indices such as WCV, MCH, MCHC, LY, MPV, T-CHO, as well as TG revealed significant changes in Sprague–Dawley rats and organ weights in lung and spleen showed diminished in male rats. Necropsy and histopathology findings suggested that no significant differences in absolute weights were found in all organs except lung and spleen, and no treatment-related alteration was identified in any organs. All results obtained in the present study indicated that the proper use of EFE in traditional medicine at oral dosages up to 1.56 g/kg/day body weight may harbor no prolonged toxicity to rats. However, further studies of EFE are still necessary to assess its oral safety in patients.

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Section: Discussionmentioning

confidence: 68%

A 90-Day Oral Toxicity Study of the Ethanol Extract from Eupatorium japonicum Thunb and Foeniculum vulgare in Rats

Dai

Wang

Tang

et al. 2020

BioMed Research International

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“…Based on this finding we suggested that different crude extracts of roots of B. pacumbis are the considerable source of antioxidant molecules and can be extracted and analyzed further in-vivo for the several health benefits. The different phenolics and flavonoids molecules present in the plant extract might be the source of antioxidant activities [6]. We next examined the plant extracts for their inhibitory potential towards α-amylase, α-glucosidase, lipase, tyrosinase, elastase, acetylcholinesterase, and butyrylcholinesterase.…”

Section: Discussionmentioning

confidence: 99%

“…Because of anti-lithiatic and diuretic activities, different species of Bergenia are used to treat kidney and urinary bladder stones and root powder is used to cure diarrhea, dysentery, thirst, vomiting, and indigestion in traditional medicine practice in Nepal, India, and China [1,2]. Numerous pharmacological activities such as antipyretic, antioxidant, antilithiatic, antiplasmodial, antitussive, antiulcer, antidiabetic, hepatoprotective, hemorrhoidal, analgesic, insecticidal, anti-inflammatory, antimicrobial, and diuretic properties have been reported in different species of Bergenia [3][4][5][6]. Although a variety of secondary metabolites have been identified from different parts of Bergenia species [6,7], the major bioactive phenolics compounds mainly concentrated in their roots; bergenin, arbutin, and gallic acid, are principal contributor of the therapeutic properties of Bergenia species [8][9][10] that leads to variation in their medicinal activities.…”

Section: Introductionmentioning

confidence: 99%

Bergenia pacumbis from Nepal, an astonishing enzymes inhibitor

Pandey

Pradhan

Adhikari

et al. 2020

BMC Complement Med Ther

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Background: The Bergenia species are perennial herbs native to central Asia, and one of the most promising medicinal plants of the family Saxifragaceae which are popularly known as 'Pashanbheda'. The aim of this study was to evaluate antioxidant and α-amylase, α-glucosidase, lipase, tyrosinase, elastase, and cholinesterases inhibition potential of Bergenia pacumbis of Nepali origin collected from the Karnali region of Nepal. Methods: The sequential crude extracts were made in hexane, ethyl acetate, methanol, and water. Antioxidant activities were analyzed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. The α-amylase, α-glucosidase, lipase, tyrosinase, elastase, acetylcholinesterase, and butyrylcholinesterase inhibition were analyzed by the 3,5-Dinitrosalicylic acid (DNSA), p-Nitrophenyl-α-Dglucopyranoside (p-NPG), 4-nitrophenyl butyrate (p-NPB), l-3,4-dihydroxyphenylalanine (L-DOPA), N-Succinyl-Ala-Alap-nitroanilide (AAAPVN), acetylthiocholine, and butyrylcholine as a respective substrate. The major metabolites were identified by high performance liquid chromatography with electron spray ionization-quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS) profiling. Results: Our results revealed the great antioxidant ability of crude extract of B. pacumbis in ethyl acetate extract against both DPPH (IC 50 = 30.14 ± 0.14 μg/mL) and ABTS (IC 50 = 17.38 ± 1.12 μg/mL). However, the crude methanol extract of B. pacumbis showed the comparable enzymes inhibitions with standard drugs; α-amylase (IC 50 = 14.03 ± 0.04 μg/mL), α-glucosidase (IC 50 = 0.29 ± 0.00 μg/mL), lipase (IC 50 = 67.26 ± 0.17 μg/mL), tyrosinase (IC 50 = 58.25 ± 1.63 μg/mL), elastase (IC 50 = 74.00 ± 3.03 μg/mL), acetylcholinesterase (IC 50 = 31.52 ± 0.58 μg/mL), and butyrylcholinesterase (IC 50 = 11.69 ± 0.14 μg/mL). On the basis of HPLC-ESI-QTOF-MS profiling of metabolites, we identified major compounds such as Bergenin, Catechin, Arbutin, Gallic acid, Protocatechuic acid, Syringic acid, Hyperoside, Afzelechin, Methyl gallate, Paashaanolactone, Astilbin, Quercetin, Kaempferol-7-O-glucoside, Diosmetin, Phloretin, and Morin in methanol extract which has reported beneficial bioactivities. Conclusion: Our study provides a plethora of scientific evidence that the crude extracts of B. pacumbis from Nepalese origin in different extracting solvents have shown significant potential on inhibiting free radicals as well as enzymes involved in digestion, skin related problems, and neurological disorders compared with the commercially available drugs.

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“…The plants of B. ciliata are traditionally used to cure various ailments such as boils, burns, cuts and wounds, fever, liver complaints, thirst, asthma, ophthalmia, piles, kidney stones, and urinary problems and diarrhoea in cattle (Kirtikar and Basu 1935;Rana and Samant 2011). Young shoots are edible, while rhizomes, leaves and roots possess anthelmintic, antitussive, anti-inflammatory, antiulcer, anticancer, antioxidant, antidiabetic, antibacterial, antifungal, antimalarial, antineoplastic activities and cytoprotective effects (Khan and Kumar 2016;Ahmad et al 2018). Due to the presence of various bioactive metabolites, B. ciliata is used as a chief botanical source for preparations of various Herbal and Unani medicines.…”

Section: Introductionmentioning

confidence: 99%

“…Bergenia ciliata has been investigated with respect to morphology (Chowdhary and Verma 2010), cytology (Kumar et al 2012), tissue culture and micropropagation (Rafi et al 2016), therapeutic activities and phytochemistry (Khan and Kumar 2016;Ahmad et al 2018). Recent studies in different parts of Indian Himalayan Region (IHR) have categorized this species as vulnerable (Khan et al 2013;Gajurel et al 2015), and near threatened (Kumari et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Molecular analyses of genetic variability in the populations of Bergenia ciliata in Indian Himalayan Region (IHR)

Tiwari

Meena

Nair

et al. 2020

Physiol Mol Biol Plants

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Bergenia ciliata is an important medicinal plant species of Indian Himalayan Region (IHR). Genetic variability and population genetic structure of B. ciliata sampled from IHR was studied using two single primer amplification reaction (SPAR) methods (DAMD: Directed Amplification of Minisatellite region DNA; ISSR: Inter Simple Sequence Repeats). To provide a reasonable scientific basis for management and conservation of B. ciliata populations in IHR, genetic diversity analysis of 11 populations with 24 SPAR markers (15 ISSR and 9 DAMD) revealed significantly high level of (90.03%) polymorphism at species level. However, genetic variability was low at population level and KUL and BWS populations showed maximum while SHM population revealed least genetic diversity among the 11 populations. Analysis of molecular variance revealed highest percentage of variation (73%) within populations, followed by 17% among populations and least (10%) among the Himalayan regions. Clustering pattern obtained from UPGMA dendrogram was supported by STRUCTURE and principal coordinate analysis, segregating all the 11 natural populations of B. ciliata into two genetic clusters: Eastern and Western Himalayan populations. The clustering patterns of all the three statistical methods indicated that populations of B. ciliata have structured in response to the local micro-climates of the habitats in IHR, and therefore, it can be concluded that genetic variability is in congruence with the geographical diversity.

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Bergenia ciliata: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety

Cited by 64 publications

References 95 publications

A 90-Day Oral Toxicity Study of the Ethanol Extract from Eupatorium japonicum Thunb and Foeniculum vulgare in Rats

A 90-Day Oral Toxicity Study of the Ethanol Extract from Eupatorium japonicum Thunb and Foeniculum vulgare in Rats

Bergenia pacumbis from Nepal, an astonishing enzymes inhibitor

Molecular analyses of genetic variability in the populations of Bergenia ciliata in Indian Himalayan Region (IHR)

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