A 90-Day Oral Toxicity Study of the Ethanol Extract from <i>Eupatorium japonicum Thunb</i> and <i>Foeniculum vulgare</i> in Rats

Dai, Guangcheng; Wang, Chenglu; Tang, Wei; Liu, Jiangyun; Xue, Boxin

doi:10.1155/2020/6859374

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…The roles of increased proliferation and insufficient apoptosis in the RA joint, which contribute to synovial membrane hyperplasia, have been previously described in this review, while several investigations are focusing on the modulating effects of natural products as well as reactive oxygen species (ROS) in this context. Eupatorium japonicum Thunb (also reported as Eupatorium chinense L.) is a widely used folk herb in many traditional Chinese herbal formulas [ 79 ]. The extract of Eupatorium japonicum Thunb was investigated among others in a study.…”

Section: Resultsmentioning

confidence: 99%

The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research

et al. 2021

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Rheumatoid arthritis (RA) is an autoimmune disorder affecting a vast variety of the population. The onset of RA as well as the development of systematic immunization is affected by both genetic and environmental risk factors. This review aims to point out the role of natural products in the management of RA, focusing on the reports of basic research (in vitro and animal studies) emphasizing the antioxidant and anti-inflammatory properties considered in the field of RA. A systematic screening of the relevant literature was carried out on PubMed, Google Scholar, and Scopus with the following criteria: publication date, 2015–2020; language, English; study design, in vitro or animal models; and the investigation of one or several natural products in the context of RA, including, when available, the molecular mechanisms implicated. A total of 211 papers were initially obtained and screened. In vitro and animal studies referring to 20 natural products and 15 pure compounds were ultimately included in this review. The outcomes of this work provide an overview of the methods employed in basic research over the past five years, with emphasis on the limitations presented, while demonstrating the potential benefits of utilizing natural products in the management of RA as supported by in vitro and animal studies.

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Section: Resultsmentioning

confidence: 99%

The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research

et al. 2021

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“…The final mean body weights of the female rats group treated at 15, 30, and 60 mg/kg were 206 ± 19.17 g, 196 ± 1.47 g, and 185 g, respectively, as compared to their initial body weight, which was 200 g. The variation in body weights suggests no compound related adverse effects on the body weight of the rats. Moreover, the decrease in body weight was of no toxicological significance, i.e., less than 10% of the mean control value [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Toxicity Profiling and Antihyperuricemic Activity of Goubion: A Polyherbal Formulation

Sadia

Naveed

Rehman

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The objective of the present study was to determine the acute and subacute toxicity profile of a polyherbal formulation called “Goubion” in addition to the in vivo antihyperuricemic study using fructose-induced hyperuricemia. Goubion is a combination of Colchicum autumnale (tuber), Tribulus terresteris (fruit), Vitex negundo (leaves), Smilax chinensis (root), Glycyrrhiza glabra (root), and Curcuma amada (rhizome). The acute toxicity study revealed no signs of mortality and morbidity at a single dose of 2000 mg/kg. Similarly, the results of the subacute repeated dose toxicity study exhibited no signs of mortality at any of the doses. However, significant changes in hematological, biochemical, and renal parameters were recorded at the dose of 60 mg/kg. Antihyperuricemic activity was tested at the dose of 15 mg/kg and 20 mg/kg of Goubion, respectively against 5 mg/kg Allopurinol. Based on the antihyperuricemic study, we infer that the Goubion has a significant hypouricemic action, as it remarkably decreased the elevated uric acid levels. The results also suggest the potential inhibitory capability of Goubion on xanthine oxidase dehydrogenase might be the mechanism behind the hypouricemic effect.

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“…Other researchers reported that platycodin D, a major saponin component of Platycodi radix, inhibits fat accumulation and adipogenesis [ 45 ]. According to Dai et al [ 28 ], it is generally accepted that a decrease of 10% body weight gain of treated rats, when compared to the control rats, is defined as toxicological significance. However, the differences in body weight and food consumption observed with respect to control in this study were minor, less than 10%, and therefore considered to be without toxicological relevance.…”

Section: Discussionmentioning

confidence: 99%

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

Sindete

Gbankoto

Osseni

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Plant medicine is the oldest form of health care known to mankind; hence, studies on their safety for use are essential for the control of adverse drug effects. In Benin, Caesalpinia bonduc is one of many medicinal plants used as aphrodisiac, and for treatment of various ailments including prostatic hyperplasia. Despite its numerous ethnomedicinal benefits, toxicological information associated with its chronic use is currently limited. Objective. The present study therefore assessed the toxicity of an ethanolic root extract of Caesalpinia bonduc in Wistar rats. Methods. Caesalpinia bonduc root extract was administered by oral gavage at doses of 31.25, 125, and 500 mg/kg/day for 90 days to male Wistar rats, after which body weight changes, food consumption, urinary parameters, hematological and blood biochemical parameters, organ weights changes, gross pathology, and histopathology of vital organs were assessed. Results. There were no death or abnormal clinical signs, no significant changes in body weight gain or urinary parameters, and no changes in necropsy and histopathology findings of vital organs associated with extract treatment. However, some indices such as erythrocytes, total cholesterol, and aspartate amino transferase increased in rats treated with high doses of the extract, as well as relative weight of testes, followed by a decrease in food intake and prostate relative weight. Conclusion. The results indicate that an ethanolic root extract of Caesalpinia bonduc does not cause significant adverse effects and suggest its tolerability up to 500 mg/kg for daily administration of 90 days.

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A 90-Day Oral Toxicity Study of the Ethanol Extract from Eupatorium japonicum Thunb and Foeniculum vulgare in Rats

Cited by 7 publications

References 25 publications

The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research

The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research

Toxicity Profiling and Antihyperuricemic Activity of Goubion: A Polyherbal Formulation

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

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