Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3

Pogostone attenuates adipose tissue inflammation by regulating the adipocyte–macrophage crosstalk via activating SIRT1

“…31,32 In our previous studies, NF-κB and MAPK signals mediated the inflammatory response in the adipose tissue of LPS-induced mice, the HFD-treated adipose tissue and the aged adipose tissue through the production of pro-inflammatory cytokines and chemokines. 12,13,15 In the current research, we showed that PO could suppress the phosphorylation of NF-κB including IKKα/β, IκBα and p65 as well as MAPK signals such as ERK, p38 and JNK in TNF-α-stimulated adipocytes, CM-challenged macrophages, and the EAT of LPS-treated mice. These findings suggested that PO might attenuate adipose tissue inflammation through inhibitory effects on NF-κB and MAPK activation in both adipocytes and macrophages.…”

“…After co-culture incubation for 4 h, the macrophages attached to the lower face were stained with DAPI, and were observed using a fluorescence microscope (Nikon) and analyzed using ImageJ as described previously. 13…”

Network Pharmacology and Molecular Docking Analysis on Targets and Mechanisms of Berberine in Atypical Antipsychotic-Induced Metabolic Syndrome

“…Numerous evidence highlighted that BBR can regulate diverse metabolic aspects and exert favorable therapeutic effects on metabolic diseases, including lowering blood glucose, increasing insulin sensitivity, ameliorating insulin resistance, regulating blood lipids, and reducing inflammation. [23][24][25][26] Recently, the atypical antipsychotics associated metabolic side effects have drawn much clinical attention. [1][2][3][4] Indeed, several studies have revealed that BBR has potential application as a therapeutic drug for antipsychotic-induced MetS.…”

Ameliorative effects of chickpea flavonoids on redox imbalance and mitochondrial complex I dysfunction in type 2 diabetic rats

“…43,44 Increasing the NAD + levels through various strategies could enhance the activity of sirtuins, improve organ function and increase longevity. 45 Li et al 46 also reported that the modulation of adipose tissue remodeling by activating Sirt3 could contribute to the antihyperlipidemic and antihyperglycemic effects of berberine. In this study, as shown in Fig.…”