Ameliorative effects of chickpea flavonoids on redox imbalance and mitochondrial complex I dysfunction in type 2 diabetic rats

Ying-hua, FU; Li, Zhenglei; Xiao, Shiqi; Zhao, Caiyun; Zhou, Keqiang; Cao, Shenyi

doi:10.1039/d2fo00753c

Cited by 6 publications

(6 citation statements)

References 62 publications

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“…NAD + /NADH redox balance is altered in diabetes; consequently, Fu et al demonstrated that crude chickpea flavonoid extract relieved NAD + /NADH redox imbalance, alleviated mitochondrial complex I dysfunction, and reduced oxidative stress in the pancreas of a T2D rat model [160].…”

Section: Phytochemicals Targeting Dr-an Evidence-based Contribution T...mentioning

confidence: 99%

Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

et al. 2023

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Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age population. The current screening process for the DR risk is not sufficiently effective such that often the disease is undetected until irreversible damage occurs. Diabetes-associated small vessel disease and neuroretinal changes create a vicious cycle resulting in the conversion of DR into PDR with characteristic ocular attributes including excessive mitochondrial and retinal cell damage, chronic inflammation, neovascularisation, and reduced visual field. PDR is considered an independent predictor of other severe diabetic complications such as ischemic stroke. A “domino effect” is highly characteristic for the cascading DM complications in which DR is an early indicator of impaired molecular and visual signaling. Mitochondrial health control is clinically relevant in DR management, and multi-omic tear fluid analysis can be instrumental for DR prognosis and PDR prediction. Altered metabolic pathways and bioenergetics, microvascular deficits and small vessel disease, chronic inflammation, and excessive tissue remodelling are in focus of this article as evidence-based targets for a predictive approach to develop diagnosis and treatment algorithms tailored to the individual for a cost-effective early prevention by implementing the paradigm shift from reactive medicine to predictive, preventive, and personalized medicine (PPPM) in primary and secondary DR care management.

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Section: Phytochemicals Targeting Dr-an Evidence-based Contribution T...mentioning

confidence: 99%

Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

et al. 2023

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“…T2DM and AD are two of the most common metabolic diseases and continue to be a leading cause of death worldwide. Evidence is growing for a strong association between mitochondria and T2DM, and mitochondrial dysfunction in peripheral insulin-responsive tissues, such as skeletal muscle, liver, and adipose tissue, is an important initiator of T2DM . For AD, a metabolic hypothesis suggests that the cause of AD might be rooted in mitochondrial dysfunction accompanied by fuel shortage in the brain .…”

Section: Resultsmentioning

confidence: 99%

“…Evidence is growing for a strong association between mitochondria and T2DM, and mitochondrial dysfunction in peripheral insulin-responsive tissues, such as skeletal muscle, liver, and adipose tissue, is an important initiator of T2DM. 14 For AD, a metabolic hypothesis suggests that the cause of AD might be rooted in mitochondrial dysfunction accompanied by fuel shortage in the brain. 10 Reduced ATP levels and glucosestimulated insulin secretion in patients with T2DM are caused by ultrastructural, morphological, and functional abnormalities in the plasma β-cell mitochondria.…”

Section: Effects Of Walnut-derived Peptide Lvrl On Learning and Memor...mentioning

confidence: 99%

“…12 We subsequently demonstrated that a peptide, LVRL, from this peptide fraction could attenuate oxidative stress occurring via IRS-1/PI3K/AKT and NRF2/HO-1 signaling by alleviating IR in high glucose-induced HepG2 cells. 13 Recognizing that mitochondria play critical roles in both T2DM and AD, 10,14 and that oxidative stress and mitochondrial dysfunction comprise a vicious cycle of interaction, 9 we hypothesized that the walnut-derived LVRL peptide may show neuroprotective effects by suppressing oxidative stress and restoring mitochondrial function in STZ-and HFD-treated T2DM mice. However, whether the walnut-derived peptide LVRL would also alleviate cognitive dysfunction�and the mechanism by which this might occur�remains to be discovered.…”

Section: ■ Introductionmentioning

confidence: 99%

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Interaction between the Neuroprotective and Hyperglycemia Mitigation Effects of Walnut-Derived Peptide LVRL via the Wnt3a/β-Catenin/GSK-3β Pathway in a Type 2 Diabetes Mellitus Model

Zhao,

Guo,

Huang

et al. 2024

J. Agric. Food Chem.

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The term type 3 diabetes mellitus (T3DM) has been considered for Alzheimer's disease (AD) due to the common molecular and cellular characteristics found between type 2 diabetes mellitus (T2DM) and cognitive deficits. However, the specific mechanism of T3DM remains elusive, especially the neuroprotective effects of dietary components in hyperglycemic individuals. In this study, a peptide, Leu-Val-Arg-Leu (LVRL), found in walnuts significantly improved memory decline in streptozotocin (STZ)and high-fat-diet (HFD)-stimulated T2DM mouse models (p < 0.05). The LVRL peptide also mitigated hyperglycemia, enhanced synaptic plasticity, and ameliorated mitochondrial dysfunction, as demonstrated by Morris water maze tests, immunoblotting, immunofluorescence, immunohistochemistry, transmission electron microscopy, and cellular staining. A Wnt3a inhibitor, DKK1, was subsequently used to verify the possible role of the Wnt3a/β-Catenin/GSK-3β pathway in glucose-induced insulin resistance in PC12 cells. In vitro LVRL treatment dramatically modulated the protein expression of p-Tau (Ser404), Synapsin-1, and PSD95, elevated the insulin level, increased glucose consumption, and relieved the mitochondrial membrane potential, and MitoSOX (p < 0.05). These data suggested that peptides like LVRL could modulate the relationship between brain insulin and altered cognition status via the Wnt3a/β-Catenin/GSK-3β pathway.

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“…Isoflavones also presented cancer prevention due to nonhormonal mechanisms, and these compounds suppress angiogenesis, induce apoptosis, and inhibit DNA topoisomerases and cancer cell differentiation (Dulce‐María et al, 2021 ). The NAD + /NADH (nicotinamide adenine dinucleotide) redox imbalance and mitochondrial complex I dysfunction in the pancreas of type 2 diabetes mellitus (T2DM) rats were corrected by chickpea flavonoids (Fu et al, 2022 ). In naturally occurring glycosidic form, isoflavones are conjugated at the 7′ position and are often esterified with acetyl or malonyl groups at the 6′ position of the sugar residue (Taylor et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition of kabuli and desi chickpea (Cicer arietinum L.) cultivars grown in Xinjiang, China

Xiao

Zhou

et al. 2022

Food Science & Nutrition

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Chickpeas are a very important legume crop and have abundant protein, carbohydrate, lipid, fiber, isoflavone, and mineral contents. The chemical compositions of the four chickpea species (Muying‐1, Keying‐1, Desi‐1, Desi‐2) from Xinjiang, China, were analyzed, and 46 different flavonoids in Muying‐1 were detected. The moisture content ranged from 7.64 ± 0.01 to 7.89 ± 0.02 g/100 g, the content of starch in the kabuli chickpeas was greater than that in the desi chickpeas, the total ash content ranged from 2.59 ± 0.05 to 2.69 ± 0.03 g/100 g and the vitamin B1 content of the chickpeas ranged from 0.31 to 0.36 mg/100 g. The lipid content ranged from 6.35 to 9.35 g/100 g and the major fatty acids of chickpeas were linoleic, oleic, and palmitic acids. Both kabuli and desi chickpeas have a high content of unsaturated fatty acids (USFAs), Muying‐1 and Desi‐1 contained the highest level of linoleic acid, and Keying‐1 had the highest oleic acid content. The protein level ranged from 19.79 ± 2.89 to 23.38 ± 0.30 g/100 g, and the main amino acids were aspartic acid, glutamic acid, and arginine acid. The four chickpea species had significant amounts of essential amino acids (EAAs). Forty‐six varieties of flavonoids in Muying‐1 were determined by ultra high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC‐QqQ‐MS) analysis, and there were higher levels of conjugate flavonoids (55.95%) than free flavonoids (44.05%). Isoflavones were the most abundant flavonoids in Muying‐1, and among the isoflavones, daidzin had the highest content, followed by biochanin A and genistin. Muying‐1 was rich in daidzin, biochanin A, genistin, troxerutin, isorhamnetin, astilbin, L‐epicatechin, astragalin, acacetin, hyperoside, and myricitrin. Information provided in the study will be helpful to further understand the chemical composition of chickpeas and be beneficial to the development of chickpeas.

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Ameliorative effects of chickpea flavonoids on redox imbalance and mitochondrial complex I dysfunction in type 2 diabetic rats

Abstract: CCFE prevented diabetes and its complications via suppressing the up-regulation of the polyol pathway and poly ADP ribose polymerase to alleviate NAD+/NADH redox imbalance, complex I dysfunction and oxidative stress.

Cited by 6 publications

References 62 publications

Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

Interaction between the Neuroprotective and Hyperglycemia Mitigation Effects of Walnut-Derived Peptide LVRL via the Wnt3a/β-Catenin/GSK-3β Pathway in a Type 2 Diabetes Mellitus Model

Chemical composition of kabuli and desi chickpea (Cicer arietinum L.) cultivars grown in Xinjiang, China

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