Berberine nanoparticles for promising sonodynamic therapy of a HeLa xenograft tumour

Liu, Han‐Qing; Zheng, Tingting; Zhou, Ziqian; Hu, Azhen; Li, Minghua; Zhang, Zhuxia; Guo, Yu; Feng, Huanhuan; An, Yu; Jiao, Peng; Chen, Yun

doi:10.1039/c8ra09172b

Cited by 13 publications

(14 citation statements)

References 34 publications

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“…However, only a few studies have proven the antitumor effects of BBR-PDT ( 15 , 31 , 59 ). The possible reasons are as follows ( 16 ): i) There are multiple factors influencing the photodynamic reactions of BBR; ii) the hydrophobic properties, along with poor stability and bioavailability of BBR limits its application; iii) BBR has high toxicity, particularly when administered by injection; and iv) the light source of BBR-PDT is UV, which has several side effects. such as burn and pain and no advantages compared with other photosensitizers ( 2 ).…”

Section: Biological Effects Of Bbr-mediated Pdtmentioning

confidence: 99%

“…The major advantage of SDT compared with PDT is the increased penetration of ultrasound through mammalian tissues compared with light, indicating that it can be used to treat deeper and less accessible tumors ( 61 , 62 ). As the light source of BBR-PDT is UV, which has several side effects, such as burn and pain, BBR-SDT may be a more favorable choice for treating tumors ( 16 ). Wang et al ( 63 ) reported that BBR can enhance ultrasound-induced BSA molecule damage.…”

Section: Biological Effects Of Bbr-mediated Pdtmentioning

confidence: 99%

“…Wang et al ( 14 ) studied the photodynamic activity of BBR on cancer cells in 1986. Our recent studies demonstrated that BBR-mediated PDT and sonodynamic therapy (SDT) significantly inhibit tumor cells in vivo ( 15 , 16 ). As a photosensitizer, BBR possesses several advantages, such as easy production, low cost and various pharmacological effects, including antitumor functions ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

“…As a photosensitizer, BBR possesses several advantages, such as easy production, low cost and various pharmacological effects, including antitumor functions ( 15 ). However, BBR also possesses several disadvantages, including toxicity and poor water solubility ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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Research progress of berberine mediated photodynamic therapy (Review)

Jin

Yuan

et al. 2021

Oncol Lett

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Berberine (BBR) is a plant secondary metabolite that has been used in photodynamic therapy (PDT) in the last few decades. The present review aimed to discuss the research progress of BBR-mediated photodynamic actions. The following key words were searched in several databases: ‘Berberine’ combined with ‘photodynamic therapy’, ‘sonodynamic therapy (SDT)’, ‘ultraviolet’, ‘reactive oxygen’ and ‘singlet oxygen’. The results demonstrated that both type I and type II reactions participated in the photodynamic progression of BBR derivatives. In addition, the photochemical characteristics of BBR derivatives were affected by the polarity, pH and O 2 content of solvents. DNA binding increases the lifespan of the photoexcited BBR state and generation of singlet oxygen ( 1 O 2 ). The chemical properties of substituents in different positions of the BBR skeleton are pivotal for its photochemical properties, particularly the methylenedioxy group at the C-2 and C-3 positions. BBR is a promising agent for mediating both PDT- and SDT-treated diseases, particularly in tumors. However, further studies are required to validate their biological effects. In addition, the molecular mechanisms underlying the antitumor effects of BBR-PDT remain unclear and warrant further investigation. The structural modification and targeted delivery of BBR have made it possible to broaden its applications; however, experimental verification is required. Overall, BBR acts as a sensitizer for PDT and has promising development prospects.

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Section: Biological Effects Of Bbr-mediated Pdtmentioning

confidence: 99%

Section: Biological Effects Of Bbr-mediated Pdtmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Research progress of berberine mediated photodynamic therapy (Review)

Jin

Yuan

et al. 2021

Oncol Lett

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“…In addition to extensive biological activities, such as anti-inflammation, antioxidative, and anti-diabetic, berberine demonstrates anti-tumor activity by means of interference in tumorigenesis and in multiple features of tumor development. Therefore, berberine is widely used in the prevention and treatment of tumors (Refaat et al, 2015;Li et al, 2017a;Liao et al, 2018;Liu et al, 2019a). In addition, it is difficult for berberine to penetrate cytomembrane and to be assimilate into the gastrointestinal tract due to its poor lipid solubility (Lu et al, 2006;Ge et al, 2016;Zhu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review

Zhang

Sheng

et al. 2020

Front. Pharmacol.

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Numerous studies have shown that berberine and its derivatives demonstrate important anti-tumor effects. However, the specific underlying mechanism remains unclear. Therefore, based on systems pharmacology, this review summarizes the information available on the anti-tumor effects and mechanism of berberine and its derivatives. The action and potential mechanism of action of berberine and its derivatives when used in the treatment of complex cancers are systematically examined at the molecular, cellular, and organismic levels. It is concluded that, with further in-depth investigations on their toxicity and efficacy, berberine and its derivatives have the potential for use as drugs in cancer therapy, offering improved clinical efficacy and safety.

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Formulating Electron Beam‐Induced Covalent Linkages for Stable and High‐Energy‐Density Silicon Microparticle Anode

Je,

Son,

Han

et al. 2024

Advanced Science

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High‐capacity silicon (Si) materials hold a position at the forefront of advanced lithium‐ion batteries. The inherent potential offers considerable advantages for substantially increasing the energy density in batteries, capable of maximizing the benefit by changing the paradigm from nano‐ to micron‐sized Si particles. Nevertheless, intrinsic structural instability remains a significant barrier to its practical application, especially for larger Si particles. Here, a covalently interconnected system is reported employing Si microparticles (5 µm) and a highly elastic gel polymer electrolyte (GPE) through electron beam irradiation. The integrated system mitigates the substantial volumetric expansion of pure Si, enhancing overall stability, while accelerating charge carrier kinetics due to the high ionic conductivity. Through the cost‐effective but practical approach of electron beam technology, the resulting 500 mAh‐pouch cell showed exceptional stability and high gravimetric/volumetric energy densities of 413 Wh kg−1, 1022 Wh L−1, highlighting the feasibility even in current battery production lines.

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Berberine nanoparticles for promising sonodynamic therapy of a HeLa xenograft tumour

Abstract: Here we show that berberine (BBR) nanoparticles (BBRNPs, ∼300 nm hydrodynamic diameter) is a promising sonosensitizer for cancer sonodynamic therapy (SDT).

Cited by 13 publications

References 34 publications

Research progress of berberine mediated photodynamic therapy (Review)

Research progress of berberine mediated photodynamic therapy (Review)

Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review

Formulating Electron Beam‐Induced Covalent Linkages for Stable and High‐Energy‐Density Silicon Microparticle Anode

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