Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Zhang, Hao; Wei, Jing; Xue, Rong; Wu, Jindan; Zhao, Wei; Wang, Zizheng; Wang, Shukui; Zhou, Zhen; Song, Dan–Qing; Wang, Yueming; Pan, Hongqiu; Kong, Weijia; Jiang, Jian‐Dong

doi:10.1016/j.metabol.2009.07.029

Cited by 356 publications

(234 citation statements)

References 37 publications

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“…Maestro et al (34) observed that vitamin D 3 induced a 1·8-fold increase in both INSR gene expression and insulin receptor number, and enhanced cellular responsiveness to insulin in terms of glucose transport (1·3-fold increase) and glucose oxidation (1·6-fold increase) in human cells. Kong et al (35) and Zhang et al (36) suggested that INSR up-regulators have clinical benefit in improving insulin sensitivity and lowering blood glucose. The vitamin D-responsive element is present in the INSR gene promoter and accounts for the transcriptional induction of the INSR gene by vitamin D 3 .…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

George¹,

Kumar

Antony

et al. 2012

Br J Nutr

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Diabetes mellitus is a growing health problem worldwide and is associated with severe liver complications. The aim of the present study is to analyse the status of metabolic and free-radical-scavenging enzymes and second messengers in the liver of streptozotocin (STZ)-induced diabetic rats, and to determine the hepatoprotective role of vitamin D 3 . All studies were performed using the liver of adult male Wistar rats. Gene expression studies were carried out using real-time PCR with specific probes. Second messenger levels were determined using 3 H-labelled Biotrak assay kits, and glucose uptake assay with D-[ 14 C]glucose. The present results show that there was a decrease in hepatic glucose uptake, malate dehydrogenase activity, glycogen content, inositol triphosphate (IP 3 ) and cyclic GMP levels, and superoxide dismutase, glutathione peroxidase, phospholipase C, cyclic AMP-responsive element-binding protein, vitamin D receptor (VDR) and insulin receptor (INSR) gene expression in the diabetic rats when compared with the controls (all P,0·05), while cyclic AMP levels and GLUT2 expression were increased (P,0·05). Treatment of the diabetic rats with vitamin D 3 and insulin reversed the altered parameters to near control values. In conclusion, the data suggest a novel role of vitamin D 3 in restoring impaired liver metabolism in STZ-induced diabetic rats by regulating glucose uptake, storage and metabolism. We demonstrated that the restoring effect of vitamin D 3 is mediated through VDR modulation, thereby improving signal transduction and controlling free radicals in the liver of diabetic rats. These data suggest a potential role for vitamin D 3 in the treatment of diabetes-associated hepatic complications.Key words: Vitamin D: Diabetes: Liver: Oxidative stress: Metabolism: Insulin Diabetes-associated complications are major causes of morbidity and mortality. The liver plays a unique role in glucose homeostasis. Because of its anatomical location, it is ideally suited to control the systemic supply of absorbed nutrients, and it is one of only two organs that both consume and produce substantial amounts of glucose. The central role of the liver in the maintenance of blood glucose levels is assured by complex regulation by metabolic substrates, insulin and other hormones (1) . Diabetes-associated hyperglycaemia and hypoinsulinaemia lead to the impairment of hepatic glucose and lipid metabolism. Virtually, the entire spectrum of liver diseases is seen in patients with diabetes, including liver cirrhosis, a significant cause of death in diabetic patients, even more relevant than CVD (2) . Interest in the development of novel antidiabetic agents has been fuelled by the intense complications due to therapeutic treatment of diabetes and associated liver failure (2,3) . An increased prevalence of diabetes has been observed in vitamin D-deficient individuals (4) , and our previous study has shown that vitamin D 3 treatment restores blood glucose homeostasis in streptozotocin (STZ)-induced diabetic rats (5) . Bind...

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Section: Discussionmentioning

confidence: 99%

Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

George¹,

Kumar

Antony

et al. 2012

Br J Nutr

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“…[13] xxv Alpha-glucosidase is an intestinal enzyme which breaks down sucrose into glucose and fructose. Alphaglucosidase inhibitors class delay and reduce the amount of glucose that is ready for absorption by interfering with the break down of the long-chain carbohydrates allowing the pancreas more time to secret einsulin to cover the meal xxvi The histological studies demonstrated severe changes in the pancreas of STZ induced hyperglycemic rats [18,19], whereas BA fruit aqueous extract treatment shows significant recovery when compared with untreated hyperglycemic rats, this could signify the regeneration of beta cells of islets of Langherhans xxvii .…”

Section: Discussionmentioning

confidence: 99%

“…Whereas no such effect were seen with methanol and chloroform extracts.The histological studies demonstrated severe changes in the pancreas of STZ induced hyperglycemic rats [18,19], whereas BA fruit aqueous extract treatment shows significant recovery when compared with untreated hyperglycemic rats, this could signify the regeneration of beta cells of islets of Langherhans xv .…”

Section: Evaluation Of Hypoglycemic Activity Of Barringtonia Acutangumentioning

confidence: 95%

“…The present study of severely diabetic animals showed significantlydeclined levels of TC, LDL, and VLDL by 23.4, 24.9 and 50.2% respectively and enhanced HDL cholesterol level by 28.4% after two weeks treatment with C. longa. Manyantihypercholesterolemic drugs do not decrease TG levels though TG plays an independent role in increasingly the riskof coronary heart disease (28,29). However, this long-termtreatment of C. longa for two weeks lowered the TG levels tooby 50.3 %.Moreover, the enhanced levels of hepatoprotective enzymesdue to severe diabetes such as SGOT, SGPT, ALP and CREwere also reduced by 28.0, 34.6, 34.6, and 8.3% respectivelyas an additional advantage of this study.…”

Section: Effect Of Curcuma Longa Freeze Dried Rhizome Powder With Milmentioning

confidence: 99%

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Scientific Exploration of Ingredients of katak Khadiradi Kashyayamfor Their Anti Diabetic Property

Ns¹

2017

IJAHM

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Abstract:-Background:-A huge number of drugs are prescribed by Ayurvedic physicians to the patients of diabeteslike diseases and number of preparation are traditionally used by different school of practitioners, since thousands of years. Among them Katak Khadiradi Kashayamhas been advocated in Sahasra Yogam(A popular book on Kerliya tradition of Ayurvedic treatment). Andis being practiced in Southern part of India,since two hundred years to treat Diabetes Mellitus. Though principally its mode of action is well established as per Ayurvedic parameters, it is a need of time to establish this on the basis of modern biochemical and pharmacological parameters. Methods:-we searched Pubmed and scholarly articles with the help of google search engine to see that is there any kind of alkaloid present in any drug of this combination which shows antidiabetic or hypoglycemic effect.For this each drug of this combination is studied separately on the basis of previous researches especially animal experiments and data is gathered. Results:-Extract of almost each drug shows anti-hyperglycemic effect along with rejunuvative and antioxidant properties in experimental or animal studies. Conclusion:-Hence, Katak Khadiradi Kashayam has an effect on protecting β-cells and smoothing out fluctuation in glucose levels. shows antidiabetic effect along with antioxidant property which can be very helpful for diabetes Mellitus.

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“…Among the various possible mechanism of berberine's antidiabetic action are through inhibition of peroxisome proliferator-activated receptors expression [42,43] carbohydrate digestion [44], various signalling pathways [45], modulation of protein tyrosine phosphatase 1B activity [46], activation of glucose transport pathway of GLUT-1 [47], promoting the secretion of glucagon-like peptide secretion [48], increasing insulin receptor expression [49], control of lipid dysregulation [50] antioxidant mechanisms and aldose reductase inhibitory activity [51], and anti-inflammatory mechanisms [52].…”

Section: Case Example 1-berberis Darwiniimentioning

confidence: 99%

The Hidden Treasure in Europe?s Garden Plants: Case Examples; Berberis darwinni and Berginia cordifolia

Habtemariam¹

2012

Med Aromat Plants

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Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Cited by 356 publications

References 37 publications

Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

Scientific Exploration of Ingredients of katak Khadiradi Kashyayamfor Their Anti Diabetic Property

The Hidden Treasure in Europe?s Garden Plants: Case Examples; Berberis darwinni and Berginia cordifolia

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Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Cited by 356 publications

References 37 publications

Effect of vitamin D3in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

Effect of vitamin D3in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

Scientific Exploration of Ingredients of katak Khadiradi Kashyayamfor Their Anti Diabetic Property

The Hidden Treasure in Europe?s Garden Plants: Case Examples; Berberis darwinni and Berginia cordifolia

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Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats

Effect of vitamin D₃in reducing metabolic and oxidative stress in the liver of streptozotocin-induced diabetic rats