Berberine inhibits inflammatory mediators and attenuates acute pancreatitis through deactivation of JNK signaling pathways

Choi, Sun-Bok; Bae, Gi‐Sang; Jo, Il‐Joo; Wang, Shaofan; Song, Ho‐Joon; Park, Sung‐Joo

doi:10.1016/j.molimm.2016.04.011

Cited by 36 publications

(30 citation statements)

References 46 publications

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“…In current study immunohistochemical examination for iNOS showed its increased expression in AP group as compared with control group and that agrees with Choi et al, 2016 [58] who found that the iNOS was markedly expressed in mice at 72 h after induction of pancreatitis by l-arginine. Moreover, few immune reactive cells were seen in between the acini, this come in line with Buchwalow et al, 2013 [59] who found increased iNOS expression in pancreatitis with strong immunostained infiltrating inflammatory cells adjacent to the affected areas.…”

Section: Discussionsupporting

confidence: 90%

Comparative Histological Study on The Effect of Bone Marrow-Derived Mesenchymal Stem Cells Versus Wheat Germ Oil on Acute Pancreatitis in A Rat Model

Aboulkhair

Nasr

Radwan

et al. 2019

Egyptian Journal of Histology

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Background: Acute pancreatitis (AP) is a common inflammatory disorder of digestive system. Mesenchymal stem cells (MSCs) and Wheat germ oil (WGO) could improve AP through their anti-inflammatory and antioxidant effects. Objective: Evaluate and compare the possible therapeutic effects of Bone marrow derived Mesenchymal Stem Cells (BMSCs) versus WGO on AP. Materials and Methods: 47 adult male albino rats were divided into 4 groups. Control group I (no.=12). AP was induced in the remaining 35 rats by a single intra peritoneal (I.P) injection of L-arginine (250 mg/100g). 5 rats died within the 1st hour after AP induction, the rest were divided randomly into group II (AP group; no.=10) that received no treatment, group III (BMSCs group; no.=10) and group IV (WGO group; no.=10). One hour after AP induction, group III was injected I.P. by 1ml of PKH26 labeled BMSCs (1x106 cells/ml) and group IV received WGO in a dose of 3 ml/kg body weight by oral gavage every 24 h for 3 successive days. Blood samples were collected 24 hours and on the 4 th day after AP induction for biochemical assessment of serum amylase, lipase, interleukin-1β and interleukin-10. Then, animals were sacrificed and specimens from the pancreas were prepared for Hematoxylin and eosin (HandE) stain and immune-histochemical staining using inducible Nitric Oxide Synthase (iNOS) and insulin antibodies. Morphometric measurements using image analyzer were done. Results: Group II showed extensive pancreatic damage associated with increase in serum amylase, lipase and interleukin-1B levels and reduction in interleukin-10 level. A significant increase in the area % of iNOS immunostaining and non-significant change in insulin immunostaining were detected. On the other hand, BMSCs group and WGO group showed improvement in the biochemical, histological and immunohistochemical results with better results in BMSCs group. Conclusion: BMSCs possess better therapeutic efficacy in treating AP compared with WGO.

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Section: Discussionsupporting

confidence: 90%

Comparative Histological Study on The Effect of Bone Marrow-Derived Mesenchymal Stem Cells Versus Wheat Germ Oil on Acute Pancreatitis in A Rat Model

Aboulkhair

Nasr

Radwan

et al. 2019

Egyptian Journal of Histology

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“…MPO activity reflects the infiltration of neutrophils into the lung, and was measured according to the method of Choi et al [17]. Briefly, lung tissue was homogenized and centrifuged.…”

Section: Methodsmentioning

confidence: 99%

Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

Hsia

Yin

2016

Nutrients

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The effects of S-ethyl cysteine (SEC) and S-methyl cysteine (SMC) on lipopolysaccharide (LPS)-induced acute lung injury in mice were examined. Eight hours after LPS challenge, SEC or SMC was supplied in drinking water at 0.5% or 1% for 3 days. LPS increased lung myeloperoxidase activity, neutrophil counts and edema. SEC or SMC post-intake attenuated these events. SEC or SMC suppressed LPS-induced lung expression of cyclooxygenase-2, nuclear factor-κB and mitogen-activated protein kinase, and lowered the generation of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and prostaglandin E2. LPS enhanced the expression of p47phox, gp91phox, Bax and cleaved caspase-3, and increased the production of reactive oxygen species in the lung. SEC or SMC post-intake reversed these alterations. These findings suggest that these agents could protect the lung through their anti-inflammatory, anti-oxidative and anti-apoptotic activities.

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“…The levels of MPO were reduced indicating potential role in the inhibition of neutrophil and macrophage infiltration. Moreover, lungs were protected from the secondary injury associated with AP, and significant protection of pancreas as well as lungs was observed histologically (Choi et al , ). This study showed that it is essential to study the pharmacological effects of active molecules in different models so as to make conclusive statements about the future of molecules for further drug discovery and development process.…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 99%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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Berberine inhibits inflammatory mediators and attenuates acute pancreatitis through deactivation of JNK signaling pathways

Cited by 36 publications

References 46 publications

Comparative Histological Study on The Effect of Bone Marrow-Derived Mesenchymal Stem Cells Versus Wheat Germ Oil on Acute Pancreatitis in A Rat Model

Comparative Histological Study on The Effect of Bone Marrow-Derived Mesenchymal Stem Cells Versus Wheat Germ Oil on Acute Pancreatitis in A Rat Model

Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

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