Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression

Kim, Haksu; Kim, Myung-Jin; Kim, Sang Hyun; Yang, Young; Lee, Myeong‐Sok; Lim, Jong‐Seok

doi:10.1016/j.bcp.2011.11.008

Cited by 151 publications

(116 citation statements)

References 48 publications

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Section: Discussionmentioning

confidence: 99%

“…43) AMPK activity is involved in cell-cell interaction 44) and inhibits the metastatic potential of several cancers. 43,45) Magnolol suppresses metastasis by inhibiting invasion, migration, and matrix metalloproteinase activities in PC-3 and HT1080 cells. 19) The antimetastatic effects of magnolol in an experimental liver and spleen metastasis model using L5178YML25 lymphoma and in an experimental and spontaneous lung metastasis model of B16-BL6 melanoma, have been evaluated.…”

Section: Discussionmentioning

confidence: 99%

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Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway

Park

Lee

Young

et al. 2012

Biological & Pharmaceutical Bulletin

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Colon cancer is the third most common malignancy around the world. Surgery, chemotherapy, and radiotherapy are generally used to treat colon cancer, but no effective therapy for advanced colon carcinoma is available. Therefore, there is a need to identify other therapeutic agents against this disease. Magnolol, a hydroxylated biphenyl compound present in Magnolia officinalis, exerts anticancer potential and low toxicity. Emerging evidence has suggested that activation of AMP-activated protein kinase (AMPK), a potential cancer therapeutic target is involved in apoptosis in colon cancer cells. However, the effects of magnolol on human colon cancer through activation of AMPK remain unexplored. In this study, we explored whether magnolol exerts an antiproliferative effect, and induces apoptosis in HCT-116 human colon cancer cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway

Park

Lee

Young

et al. 2012

Biological & Pharmaceutical Bulletin

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“…In addition to its well‐characterized roles in energy regulation, AMPK more recently has been shown to be important in the maintenance and dynamic repair of intercellular tight junctions,35, 36 enhancement of cell‐cell contacts,37 induction of phenotypic differentiation, and determination of cell polarity 38, 39, 40. Although the net effects of AMPK activation or inhibition on the function of the equine LBEC are unknown, it may play a role in this highly polarized, structurally critical cell type.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Nonstructural Carbohydrate Content on Activation of 5′‐Adenosine Monophosphate‐Activated Protein Kinase in Liver, Skeletal Muscle, and Digital Laminae of Lean and Obese Ponies

Burns

Watts

Weber

et al. 2014

Veterinary Internal Medicne

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BackgroundIn EMS‐associated laminitis, laminar failure may occur in response to energy failure related to insulin resistance (IR) or to the effect of hyperinsulinemia on laminar tissue. 5′‐Adenosine‐monophosphate‐activated protein kinase (AMPK) is a marker of tissue energy deprivation, which may occur in IR.Hypothesis/ObjectivesTo characterize tissue AMPK regulation in ponies subjected to a dietary carbohydrate (CHO) challenge.AnimalsTwenty‐two mixed‐breed ponies.MethodsImmunohistochemistry and immunoblotting for total AMPK and phospho(P)‐AMPK and RT‐qPCR for AMPK‐responsive genes were performed on laminar, liver, and skeletal muscle samples collected after a 7‐day feeding protocol in which ponies stratified on body condition score (BCS; obese or lean) were fed either a low‐CHO diet (ESC + starch, approximately 7% DM; n = 5 obese, 5 lean) or a high‐CHO diet (ESC + starch, approximately 42% DM; n = 6 obese, 6 lean).Results5′‐Adenosine‐monophosphate‐activated protein kinase was immunolocalized to laminar keratinocytes, dermal constituents, and hepatocytes. A high‐CHO diet resulted in significantly decreased laminar [P‐AMPK] in lean ponies (P = .03), but no changes in skeletal muscle (lean, P = .33; obese, P = .43) or liver (lean, P = .84; obese, P = .13) [P‐AMPK]. An inverse correlation existed between [blood glucose] and laminar [P‐AMPK] in obese ponies on a high‐CHO diet.Conclusions and Clinical ImportanceLaminar tissue exhibited a normal response to a high‐CHO diet (decreased [P‐AMPK]), whereas this response was not observed in liver and skeletal muscle in both lean (skeletal muscle, P = .33; liver, P = .84) and obese (skeletal muscle, P = .43; liver, P = .13) ponies.

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“…Chemokine ligand 3 (CCL-3) can promote MMP-2 expression and the migration of human chondrosarcoma cells, which is abolished by AMPK activation (63). Kim et al reported that berberine dramatically increased AMPK phosphorylation but decreased ERK activity and cytochrome c oxidase subunit II (COX-2) expression, leading to suppression of human melanoma cell migration (64). These studies suggest that AMPK plays an important role in tumor invasion and migration.…”

Section: Regulation Of Tumor Cell Invasion and Migration By Lkb1/ampkmentioning

confidence: 97%

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)

Huang

Lü

et al. 2015

Oncology Reports

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Abstract. Liver kinase B1 (LKB1), also known as serine/threo nine kinase 11 (STK11), is a tumor suppressor that is inactivated in Peutz-Jeghers familial cancer syndrome. LKB1 phosphorylates and activates AMP-activated protein kinase (AMPK), which negatively regulates cancer cell proliferation and metabolism. However, recent evidence demonstrates that the LKB1/AMPK pathway is involved in the process of tumor invasion and migration, which is an important hallmark of carcinoma progression to higher pathological grades of malignancy. This review focuses on the function of the LKB1/AMPK pathway in the invasion and migration of cancer cells and provides an overview of therapeutic strategies aimed at this pathway in malignant tumors.

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Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression

Cited by 151 publications

References 48 publications

Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway

Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway

Effect of Dietary Nonstructural Carbohydrate Content on Activation of 5′‐Adenosine Monophosphate‐Activated Protein Kinase in Liver, Skeletal Muscle, and Digital Laminae of Lean and Obese Ponies

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)

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