Berberine, a Traditional Chinese Medicine, Reduces Inflammation in Adipose Tissue, Polarizes M2 Macrophages, and Increases Energy Expenditure in Mice Fed a High-Fat Diet

Lin, Jiayu; Cai, Qingyan; Liang, Bo; Wu, Lizhen; Zhuang, Yong; He, Yuanfang; Lin, Wanrong

doi:10.12659/msm.911849

Cited by 28 publications

(27 citation statements)

References 35 publications

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“…5 C and D). These results are similar to previous reports of BBR induced thermogenesis in obese db/db male mice (Zhang et al, 2014) and HF fed mice (Sun et al, 2018;Lin et al, 2019). In addition, BBR appears to target white adipose tissue directly to reduce hypertrophy and hyperplasia (Ko et al, 2005).…”

Section: Dietary Bbr Supplementation Reduced Obesity In Male and Femasupporting

confidence: 91%

“…Previous reports showed that BBR supplementation reduced the body weight of lean and obese rodents (Lee et al, 2006;Zhao et al, 2017;Sun et al, 2018;Lin et al, 2019). BBR also reduced body fat content, with reduced storage of TG in white adipose tissue (Lee et al, 2006).…”

Section: Dietary Bbr Supplementation Reduced Obesity In Male and Femamentioning

confidence: 92%

“…The anti-obesity effect of BBR treatment has been correlated with reductions in hepatic steatosis (Zhao et al, 2017;Sun et al, 2018;Lin et al, 2019). In general, significant reductions in hepatic TG accumulation have been achieved with >10% reductions in body weight due to less NEFA released from a smaller mass of adipose tissue (Vilar-Gomez et al, 2015).…”

Section: The Effects Of Bbr Treatment On Hepatic Metabolismmentioning

confidence: 99%

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Berberine Alleviates Adiposity and Cardiac Dysfunction in Offspring Exposed to Gestational Diabetes Mellitus

Cole

Zhang

Chen

et al. 2020

Preprint

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The most robust risk factor for type 2 diabetes in childhood is prior exposure to diabetes during gestation. Currently, there are few evidence-based strategies to attenuate the of risk of metabolic syndrome in offspring exposed to gestational diabetes mellitus (GDM). Berberine (BBR) is an isoquinoline alkaloid extracted from Chinese herbs and exhibits glucose lowering properties. It has been used safely for centuries in humans. Our objective was to determine whether BBR treatment improves health outcomes in the mouse offspring of GDM dams. Dams were fed either a lean low-fat diet (Lean, LF,10% kcal fat) or a GDM-inducing high-fat/high sucrose diet (GDM, HF, 45% kcal fat) prior to breeding and throughout pregnancy. The resulting Lean and GDM-exposed offspring were randomly assigned a LF, HF or HF diet containing BBR (160 mg/kg/d) for 12 weeks. We determined that BBR treatment significantly reduced body weight (∼20%), % body fat (∼40%) and gonadal fat pad mass (∼60%) compared to HF-fed GDM offspring. Furthermore, BBR treatment of HF-fed GDM offspring normalized insulin levels in the plasma and isolated pancreatic islets. Differences in food consumption did not contribute to altered body composition in BBR treated mice, as levels remained similar between experimental groups. Alternatively, BBR-treatment was associated with increased whole-body oxygen consumption (VO2), activity and heat production. Additionally, we determined that HF-fed GDM offspring developed a cardiomyopathy, characterized by increased isovolumetric contraction (∼150%, IVCT), relaxation time (∼70%, IVRT), elevated cardiac triglyceride (∼120%) and reduced mitochondrial function (30%, spare capacity) compared to LF fed Lean controls. BBR treatment normalized heart function, reduced triglyceride levels and maintained mitochondrial function. Our data supports BBR as a potential pharmacotherapeutic approach to improve health outcomes in individuals exposed to GDM.Key Points SummaryGestational diabetes mellitus is a common metabolic complication of pregnancy which is increasing worldwide due to the prevalence of obesity.It is known that individuals exposed to gestational diabetes have elevated risk of developing metabolic syndrome however there are few evidence-based strategies which provide protection.Berberine is a natural compound found in Chinese herbs which has been safely used for centuries to treat type 2 diabetes mellitus.We determined that berberine treatment of offspring exposed to gestational diabetes attenuated weight gain, reduced insulin levels and normalized both heart and pancreatic function.Our data supports berberine as a potential pharmacotherapeutic approach to improve health outcomes in individuals exposed to gestational diabetes.

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Section: Dietary Bbr Supplementation Reduced Obesity In Male and Femasupporting

confidence: 91%

Section: Dietary Bbr Supplementation Reduced Obesity In Male and Femamentioning

confidence: 92%

Section: The Effects Of Bbr Treatment On Hepatic Metabolismmentioning

confidence: 99%

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Berberine Alleviates Adiposity and Cardiac Dysfunction in Offspring Exposed to Gestational Diabetes Mellitus

Cole

Zhang

Chen

et al. 2020

Preprint

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“…The M2 population is normally predominant in AT of lean mice and a shift to M1 occurs as obesity progresses [29]. Activation of the M2 population contributes to the upregulation of immunomodulatory cells, mainly Tregs [57]. Macrophage-released CXCL2 which is upregulated in obesity stimulates the adhesion of neutrophils to WAT endothelial cells and may accelerate their infiltration in AT [58].…”

Section: Role Of Monocytes and Macrophage Within Atmentioning

confidence: 99%

Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions

Komi

Shafaghat

Christian

2020

Clinic Rev Allerg Immunol

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Excessive fatty acids and glucose uptake support the infiltration of adipose tissue (AT) by a variety of immune cells including neutrophils, pro-inflammatory M1 macrophages, and mast cells (MCs). These cells promote inflammation by releasing proinflammatory mediators. The involvement of MCs in AT biology is supported by their accumulation in the AT of obese individuals along with significantly higher serum levels of MC-derived tryptase. AT-resident MCs under the influence of locally derived adipokines such as leptin become activated and release pro-inflammatory cytokines including TNFα that worsens the inflammatory state. MCs support angiogenesis in AT by releasing chymase and inducing preadipocyte differentiation and also the proliferation of adipocytes through 15-deoxy-delta PGJ2/PPARγ interaction. Additionally, they contribute to the remodeling of the AT extracellular matrix (ECM) and play a role in the recruitment and activation of leukocytes. MC degranulation has been linked to brown adipocyte activation, and evidence indicates an important link between MCs and the appearance of BRITE/beige adipocytes in white AT. Cell crosstalk between MCs and AT-resident cells, mainly adipocytes and immune cells, shows that these cells play a critical role in the regulation of AT homeostasis and inflammation.

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“…Nrf2 is involved in upregulation of MDR1 and anti-inflammatory after berberine treated DSS-Induced Colitis [ 144 ]. Polarized M2 macrophages were appeared after a regiment of berberine administration (100 mg/kg/d for 16 weeks) in adipose tissue [ 145 ]. Thus, the Nrf2-mediated transcriptional inhibition is controlling a suppressive role for M1 macrophages polarization.…”

Section: Gsk3β-mediated Inflammation In Heartmentioning

confidence: 99%

GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

Liu

Chiang

Kao

et al. 2020

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Berberine, a Traditional Chinese Medicine, Reduces Inflammation in Adipose Tissue, Polarizes M2 Macrophages, and Increases Energy Expenditure in Mice Fed a High-Fat Diet

Cited by 28 publications

References 35 publications

Berberine Alleviates Adiposity and Cardiac Dysfunction in Offspring Exposed to Gestational Diabetes Mellitus

Berberine Alleviates Adiposity and Cardiac Dysfunction in Offspring Exposed to Gestational Diabetes Mellitus

Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions

GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

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