Berbamine Hydrochloride inhibits lysosomal acidification by activating Nox2 to potentiate chemotherapy-induced apoptosis via the ROS-MAPK pathway in human lung carcinoma cells

Zhan, Yujuan; Chen, Qiugu; Song, Yue; Wei, Xianli; Zhao, Tingxiu; Chen, Bonan; Li, Chengxi; Zhang, Wenbo; Jiang, Yanjun; Tan, Yu‐Hui; Du, Baoheng; Xiao, Jianru; Wang, Kun

doi:10.1007/s10565-022-09756-8

Cited by 6 publications

(2 citation statements)

References 52 publications

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“…Berbamine Hydrochloride is derived from Coptis Chinensis and has an anti-tumor function ( 284 – 286 ). Berbamine Hydrochloride can activate Nox2 to resist lysosomal acidification and, therefore, inhibit lung cancer cell autophagy, which may potentiate the effect of chemotherapy ( 277 ).…”

Section: Natural Products Targeting Immune Checkpoints or Combined Wi...mentioning

confidence: 99%

“…Erianin extracted from the Dendrobium Chrysostom also can downregulate IDO mRNA and protein levels (274,281). Dihydroartemisinin (DHA), derived from the antimalarial drug Artemisia annua, can downregulate B7-H3 expression (275,282). Calotropin isolated from Asclepias curasavica L can repress CTLA-4 expression (276, 283).…”

Section: Natural Products Targeting Other Immune Checkpointsmentioning

confidence: 99%

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From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer

Zhou,

Wang,

et al. 2024

Front. Immunol.

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Lung cancer is a disease of global concern, and immunotherapy has brought lung cancer therapy to a new era. Besides promising effects in the clinical use of immune checkpoint inhibitors, immune-related adverse events (irAEs) and low response rates are problems unsolved. Natural products and traditional medicine with an immune-modulating nature have the property to influence immune checkpoint expression and can improve immunotherapy’s effect with relatively low toxicity. This review summarizes currently approved immunotherapy and the current mechanisms known to regulate immune checkpoint expression in lung cancer. It lists natural products and traditional medicine capable of influencing immune checkpoints or synergizing with immunotherapy in lung cancer, exploring both their effects and underlying mechanisms. Future research on immune checkpoint modulation and immunotherapy combination applying natural products and traditional medicine will be based on a deeper understanding of their mechanisms regulating immune checkpoints. Continued exploration of natural products and traditional medicine holds the potential to enhance the efficacy and reduce the adverse reactions of immunotherapy.

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Section: Natural Products Targeting Immune Checkpoints or Combined Wi...mentioning

confidence: 99%

Section: Natural Products Targeting Other Immune Checkpointsmentioning

confidence: 99%

From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer

Zhou,

Wang,

et al. 2024

Front. Immunol.

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show abstract

Gold nanoparticles enhance proliferation and osteogenic differentiation of periodontal ligament stem cells by PINK1-mediated mitophagy

Wang¹,

Liu²,

Yang³

et al. 2023

Archives of Oral Biology

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Targeting tumor-derived exosome-mediated premetastatic niche formation: The metastasis-preventive value of traditional Chinese medicine

Jia¹,

Yuan²,

Cheng³

et al. 2023

Cancer Letters

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Berbamine Hydrochloride inhibits lysosomal acidification by activating Nox2 to potentiate chemotherapy-induced apoptosis via the ROS-MAPK pathway in human lung carcinoma cells

Cited by 6 publications

References 52 publications

From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer

From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer

Gold nanoparticles enhance proliferation and osteogenic differentiation of periodontal ligament stem cells by PINK1-mediated mitophagy

Targeting tumor-derived exosome-mediated premetastatic niche formation: The metastasis-preventive value of traditional Chinese medicine

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