Gold nanoparticles enhance proliferation and osteogenic differentiation of periodontal ligament stem cells by PINK1-mediated mitophagy

Wang, Qi; Liu, Jian; Yang, Xiaomei; Zhang, Hongjie; Li, Yantao

doi:10.1016/j.archoralbio.2023.105692

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…229 Niu et al found GNSs with various sizes (5, 10, 20, 40, and 80 nm) enhanced the proliferation and osteogenic differentiation of PDLCs, improved mitochondrial quality and homeostasis, attenuated mitochondrial quantity, and activated PTEN-induced putative kinase 1-mediated mitophagy. 230 We also found that GNPs can synergistically promote the osteogenic differentiation of hPDLCs with human β-defensin 3 (hBD3) in inflammatory microenvironments. 231,232 The combination of GNPs with hBD3 led to a substantial enhancement in ALP activities and the deposition of minerals in vitro .…”

Section: Therapeutic Applications Of Engineered Gnss In Dentistrymentioning

confidence: 83%

Nanochemistry of gold: from surface engineering to dental healthcare applications

Zhang,

Kong,

Wang

et al. 2024

Chem. Soc. Rev.

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Section: Therapeutic Applications Of Engineered Gnss In Dentistrymentioning

confidence: 83%

Nanochemistry of gold: from surface engineering to dental healthcare applications

Zhang,

Kong,

Wang

et al. 2024

Chem. Soc. Rev.

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“…PDLSCs also increased mitophagy. PINK1 activation enhanced mitophagy, mitochondrial quality, homeostasis, and osteogenic differentiation in PDLSCs through AuNPs in a synergistic manner [ 71 ].…”

Section: Metal Nanoparticles In Periodontitismentioning

confidence: 99%

Recent advances in metal nanoparticles to treat periodontitis

Nasiri,

Masoumi,

Amini

et al. 2023

J Nanobiotechnol

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The gradual deterioration of the supporting periodontal tissues caused by periodontitis, a chronic multifactorial inflammatory disease, is thought to be triggered by the colonization of dysbiotic plaque biofilms in a vulnerable host. One of the most prevalent dental conditions in the world, periodontitis is now the leading factor in adult tooth loss. When periodontitis does develop, it is treated by scraping the mineralized deposits and dental biofilm off the tooth surfaces. Numerous studies have shown that non-surgical treatment significantly improves clinical and microbiological indices in individuals with periodontitis. Although periodontal parameters have significantly improved, certain bacterial reservoirs often persist on root surfaces even after standard periodontal therapy. Periodontitis has been treated with local or systemic antibiotics as well as scaling and root planning. Since there aren't many brand-new antibiotics on the market, several researchers are currently concentrating on creating alternate methods of combating periodontal germs. There is a delay in a study on the subject of nanoparticle (NP) toxicity, which is especially concerned with mechanisms of action, while the area of nanomedicine develops. The most promising of them are metal NPs since they have potent antibacterial action. Metal NPs may be employed as efficient growth inhibitors in a variety of bacteria, making them useful for the treatment of periodontitis. In this way, the new metal NPs contributed significantly to the development of efficient anti-inflammatory and antibacterial platforms for the treatment of periodontitis. The current therapeutic effects of several metallic NPs on periodontitis are summarized in this study. This data might be used to develop NP-based therapeutic alternatives for the treatment of periodontal infections. Graphical Abstract

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Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Zhang,

Yang,

Guo

et al. 2024

J of Applied Toxicology

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Mitophagy is a selective cellular process critical for the removal of damaged mitochondria. It is essential in regulating mitochondrial number, ensuring mitochondrial functionality, and maintaining cellular equilibrium, ultimately influencing cell destiny. Numerous pathologies, such as neurodegenerative diseases, cardiovascular disorders, cancers, and various other conditions, are associated with mitochondrial dysfunctions. Thus, a detailed exploration of the regulatory mechanisms of mitophagy is pivotal for enhancing our understanding and for the discovery of novel preventive and therapeutic options for these diseases. Nanomaterials have become integral in biomedicine and various other sectors, offering advanced solutions for medical uses including biological imaging, drug delivery, and disease diagnostics and therapy. Mitophagy is vital in managing the cellular effects elicited by nanomaterials. This review provides a comprehensive analysis of the molecular mechanisms underpinning mitophagy, underscoring its significant influence on the biological responses of cells to nanomaterials. Nanoparticles can initiate mitophagy via various pathways, among which the PINK1‐Parkin pathway is critical for cellular defense against nanomaterial‐induced damage by promoting mitophagy. The role of mitophagy in biological effects was induced by nanomaterials, which are associated with alterations in Ca2+ levels, the production of reactive oxygen species, endoplasmic reticulum stress, and lysosomal damage.

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Gold nanoparticles enhance proliferation and osteogenic differentiation of periodontal ligament stem cells by PINK1-mediated mitophagy

Cited by 6 publications

References 31 publications

Nanochemistry of gold: from surface engineering to dental healthcare applications

Nanochemistry of gold: from surface engineering to dental healthcare applications

Recent advances in metal nanoparticles to treat periodontitis

Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

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