�ber erythrolytische Nephrose

Letterer, E; Masshoff, W

doi:10.1007/bf00947983

Cited by 20 publications

(6 citation statements)

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“…The cytological findings in the spleen conform with the results of examinations of the electrophoretic pattern made by Letterer (1949) and Bohle and others (1950) in mice during the development of experimental amyloidosis. Letterer thus found a higher y-globulin increase in amyloidosis-affected mice than in non-affected mice after fifteen injections of nucleic acid.…”

Section: Morphological Phases In Formation Of Amyloidsupporting

confidence: 88%

“…The ANNALS OF THE RHIEUMATIC DISEASES morphogenetic relations of hyalinosis, amyloidosis, and paramyloidosis in mesenchymal disease associated with hyperglobulinaemia and accumulations of plasma cells in the active phase have recently been studied in detail (Teilum, 1948a, b;1949).…”

mentioning

confidence: 99%

“…Letterer (1949), who studied the electrophoretic pattern of serum protein in amyloid mice, believes that the protein constituent of amyloid is not of a specific chemical nature, but a part of plasma protein, and in many cases the result of antigen-antibody reactions. Two processes appeared to be of importance: the disturbance of the colloidal stability of the plasma, and the formation of new plasma proteins of a, fi, and y types (Letterer, 1949).…”

mentioning

confidence: 99%

“…Letterer (1926) and Bohle and others (1950) produced experimental amyloidosis in mice by means of repeated injections of sodium caseinate or of nucleic acid solution. The incidence of amyloidosis in such experiments seems, however, to be varying, andHass and others (1943) failed to produce amyloidosis in mice which were given injections of a solution of sterile sodium caseinate.…”

mentioning

confidence: 99%

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Cortisone-Ascorbic Acid Interaction and the Pathogenesis of Amyloidosis : Mechanism of Action of Cortisone on Mesenchymal Tissue

Teilum¹

1952

Annals of the Rheumatic Diseases

128

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Section: Morphological Phases In Formation Of Amyloidsupporting

confidence: 88%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Cortisone-Ascorbic Acid Interaction and the Pathogenesis of Amyloidosis : Mechanism of Action of Cortisone on Mesenchymal Tissue

Teilum¹

1952

Annals of the Rheumatic Diseases

128

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“…However, repeated tests with varying dilutions of antigen and of the rabbit ~era were negative. (7,8) found that subcutaneous injections of EXPERIMENTAL HYPERGLOBULI NEMIA alkaline solutions of ribonucleic acid into mice often gave rise to transitory elevations in serum globulin levels similar to those observed in rabbits treated with ribonucleate alone in the present experiments ( Fig. 1).…”

Section: Monthssupporting

confidence: 82%

Experimental Hyperglobulinemia

Richter

1952

Journal of Experimental Medicine

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Although hyperglobulinemia is frequently seen in a number of diseases, notably multiple myeloma, lymphogranuloma venereum, kala azar, sarcoidosis, amyloidosis, disseminated lupus erythematosus, and hypersensitive states (1--4), its pathogenesis in these various circumstances remains largely unknown. Furthermore, apart from a few investigations on the hyperglobulinemia associated with ~rnrounization and with amyloidosis (5-9), the condition has not been studied experimentally. The phenomenon of hyperglobulinemia is necessarily related to the more fundamental problem of how proteins are formed by the living organism. In recent years numerous cytological and chemical studies have provided evidence that nucleotides are involved in the formation of proteins in diverse animal and plant cells (10-15), and it has been reported that an increase in cytoplasmic ribonucleotides develops in cells which may be actively engaged in the production of antibody globulins (16-18). It should be noted, however, that the part played by nucleotides in proteosynthesis has been inferred from correlations of cytological observations and chemical analyses, not from direct evidence; as pointed out by Brachet, the relation between nucleic acids and the synthesis of proteins is far from being solved (15).The experiments now to be reported were undertaken to study directly the relationship of ribonucleotides to globulin formation, and hence to learn more about the pathogenesis of hyperglobulinemia. The findings show that repeated injection of a ribonucleotide into rabbits undergoing immunization with horse serum markedly enhances the production of serum globulins; they indicate also that most of the globulin appearing in the blood under such circumstances differs from that comprising the specific antibodies resulting from the immunization.

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Wetzels¹

1964

Einzelfunktionen Der Niere Beim Akuten Nierenversagen

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�ber erythrolytische Nephrose

Cited by 20 publications

References 19 publications

Cortisone-Ascorbic Acid Interaction and the Pathogenesis of Amyloidosis : Mechanism of Action of Cortisone on Mesenchymal Tissue

Cortisone-Ascorbic Acid Interaction and the Pathogenesis of Amyloidosis : Mechanism of Action of Cortisone on Mesenchymal Tissue

Experimental Hyperglobulinemia

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