�ber die Enzymaktivit�t im Fremdk�rpergranulationsgewebe

Gedigk, P.; E, Bontke

doi:10.1007/bf00956748

Cited by 67 publications

(5 citation statements)

References 23 publications

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“…The roles of these lipopolysaccharides in the development of immunity are not clearly understood. One of these roles is the nonspecific stimulation of macrophages in the local lesion (60,61,173). Another is the production of specific antibodies to the phospholipids and polysaccharides of the bacillus (18,54,112,113,122,152,172).…”

Section: General Aspects Of Cellular Hypersensi-tivrry and Cellular Imentioning

confidence: 99%

“…26, 69), tissue debris, and bacillary lipids, e.g., cell walls or Wax D (cf. 60,61,128,133,168,173). Thus, in the local lesion, the macrophages become highly activated, probably because of both immunological factors, like stimulation by tuberculin, and nonspecific factors, like stimulation by bacillary and tissue lipids and other substances.…”

Section: Local Nature Of Cellular Immunity In Tuberculosismentioning

confidence: 99%

“…Histochemical studies in other laboratories are consistent with these conclusions. Macrophages in granulomatous lesions were found to be rich in acid phosphatase (60,61,70,173), /3-glucuron-idase (60, 61, 70), succinic dehydrogenase (61,173), cytochrome oxidase (61, 173), aminopeptidase (60, 61), phosphamidase (60: 61), nonspecific esterase (61), and nicotinamide adenine dinucleotide diaphorase (61).…”

Section: Local Nature Of Cellular Immunity In Tuberculosismentioning

confidence: 99%

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Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

Dannenberg¹

1968

Bacteriological Reviews

113

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This article makes no attempt to review the literature in a complete fashion, but relies on articles which do so. References to such articles are printed in italic type. In this review, cellular hypersensitivity, cellular allergy, and delayed hypersensitivity are used interchangeably; and macrophage activation is used synonymously with macrophage maturation and macrophage differentiation. Although macrophages frequently proliferate during the activating process, activation can occur without proliferation. These two terms are therefore used independently. with current knowledge. These assumptions are then used to explain the known facts concerning the pathogenesis of tuberculosis. Finally, the relative importance of local and systemic aspects of cellular immunity is discussed. Nature and Effects of Cellular Hypersensitivity In tuberculosis, cellular hypersensitivity, the delayed type of allergy, may be defined as an immunological state in which lymphocytes and macrophages are directly or indirectly sensitive to tuberculin. As a result of this sensitivity, tuberculin in the appropriate low concentration will activate macrophages, i.e., cause the production of new lysosomes and other organelles as well 85

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Section: General Aspects Of Cellular Hypersensi-tivrry and Cellular Imentioning

confidence: 99%

Section: Local Nature Of Cellular Immunity In Tuberculosismentioning

confidence: 99%

Section: Local Nature Of Cellular Immunity In Tuberculosismentioning

confidence: 99%

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Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

Dannenberg¹

1968

Bacteriological Reviews

113

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“…Most of the other studies concerned acid phosphatase whose activity was increased (a) in Kupffer cells most active in the phagocytosis of particles from the blood stream (63,123,126,127), (b) in MN in contact with various foreign bodies placed subcutaneously in mice and rats (128), (c) in the reticular cells of the rabbit appendix that had ingested the cell debris caused by radiation damage (129) and lymph nodes following the intravenous injection of killed typhoid bacteria (63) and in those of the liver following the ip injection of Salmonella typhimurium (130), (e) in mouse macrophages that had ingested red corpuscles in the peritoneal cavity (62), and (/) in alveolar phagocytes containing the most dust particles (this report). In addition, both the acid phosphatase and phagocytic activities of Kupffer cells can be increased by endotoxins (123,126,127).…”

Section: In Vivo Activation Of Mnmentioning

confidence: 99%

A Histochemical Study of Phagocytic and Enzymatic Functions of Rabbit Mononuclear and Polymorphonuclear Exudate Cells and Alveolar Macrophages

Dannenberg

Burstone

Walter

et al. 1963

The Journal of Cell Biology

127

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The cytochromc oxidasc (CO), aminopcptidasc (AMP), succinic dchydrogcnasc (SD), acid phosphatasc, cstcrasc, and alkaline phosphatasc of rabbit mononuclcar (MN) and polymorphonuclcar (PMN) peritoneal cxudatc cells and pulmonary alveolar macrophagcs (AM) -air dried on Mylar strips-were characterized by histochcmical techniques with respect to stability, activators, inhibitors, and pH optima. A granule count method was established for the quantitation of these cnzymcs. For the acid phosphatasc of MN, in which the most precise results wcrc obtained, time, pH, substratc, and inhibitor curves resembled those commonly obtained biochcmically. Five of these enzymes wcrc usually more active in AM than MN, whereas the sixth, alkaline phosphatasc, was not present in cithcr cell type. AM also tended to consume more oxygen than MN and to divide more frequently. Since the most active cells in thc population would bc first involved in the host's defense against microbial agents, a comparison was made of the 10 per cent of the AM and MN with the highest enzymatic activities. No differences wcrc found in the granule counts that wcrc not reflected by the means. However, within a given AM population, cells containing ingested dust particles sccmcd to have higher enzymatic activities than those without particles. MN had greater acid phosphatasc and SD activities than PMN and consumcd more oxygen, but the CO, AMP, and cstcrasc activitcs of both types of cells wcrc of similar magnitude. PMN showed high alkaline phosphatasc activity; MN showed none. A survcy of the histochcmical litcraturc indicates that a positive correlation between the enzymatic and phagocytic activities of both MN and PMN exists in vivo.Mononuclear phagocytes (MN) 1 are essential components of the reticuloendothelial system--the chief defense of the host against many micro organisms and their products. Similar functions i The abbreviations used in this report are as follows : MN, mononuclear(s), or mononuclear peritoneal exudate cells; PMN, polymorphonuclear(s) or polymorphonuclear peritoneal exudate cells; AM, are served by polymorphonuclears (PMN) in the blood and in areas of inflammation, and by alveolar macrophages (AM) in the lung. The present report (a) characterizes six enzymes of rabbit MN alveolar macrophage(s) of the lung; ip, intraperitoneal; CO, cytochrome oxidase; AMP, aminopeptidase; SD,succinic dehydrogenase; Tris, tris(hydroxymethyl) aminomethane. 465on

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“…Vanemad autoriu pidasid neid bioloogiliselt mittetäisväärtuslikeks rakkudeks. Uuemate uurimuste alusel on nad kõrge ainevahetusliku aktiivsusega rakud (Linzbach, 1955;Gedigk, Bontke, 1957;Gusek, 1958). Hiidrakkude geneesi suhtes on enamik autoreid arvamusel, et nad tekivad tuumade amitootilise jagunemise teel makrofaagidest (Wurm, 1956;Gusek, 1958Gusek, , 1962.…”

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HAAVA PARANEMINE SILIKOOSI PUHUL II. Organisatsiooniprotsessi histokeemiline iseloomustus (Eksperimentaalne uurimus)

Ehlvest¹

1965

Eesti NSV Teaduste Akadeemia Toimetised. Bioloogiline Seeria

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�ber die Enzymaktivit�t im Fremdk�rpergranulationsgewebe

Cited by 67 publications

References 23 publications

Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

A Histochemical Study of Phagocytic and Enzymatic Functions of Rabbit Mononuclear and Polymorphonuclear Exudate Cells and Alveolar Macrophages

HAAVA PARANEMINE SILIKOOSI PUHUL II. Organisatsiooniprotsessi histokeemiline iseloomustus (Eksperimentaalne uurimus)

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