Adenomatous changes, and early and invasive carcinomas of the glandular stomach in Wistar rats ingesting N-methyl-N'-nitro-N-nitrosoguanidine were studied. Almost all adenomatous changes and carcinomata were located near the midpoint of the lesser curvature. In electron microscopic and histochemical studies, both changes showed great cytological similarity. Electron microscopically, they were found to consist of predominantly undifferentiated cells with poorly developed cytoplasmic organelles, with some highly differentiated cells present. Histochemically, both showed strongly positive reactions for lysosomal enzymes. For tumor transplantation, five lesions were used and in all cases, the transplants were successful.
Während der durch das ,Marburg-Virus' verursachten Epidemie starben in Marburg fünf Patienten. Uber das Ergebnis der Autopsien und der bisher vorgenommenen feingeweblichen Untersuchungen soll im folgenden berichtet werden. Dabei möchten wir uns in dieser ersten Mitteilung nur auf die wesentlichen, mit der Krankheit direkt oder indirekt in Zusammenhang stehenden Veränderungen beschrän-ken1.Um einen Einblick in die formale Genese und den Ablauf der morphologischen Veränderungen zu gewinnen, haben wir die Fälle nach der Erkrankungsdauer, das heißt nach der Zeitdauer, die zwischen den ersten klinischen Symptomen und dem Eintritt des Todes verstrichen war, eingeteilt.
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