�ber die Abh�ngigkeit der Strahlenschutzwirksamkeit des 5-Hydroxytryptamins von Konzentration und Zeitfaktor

Melching, H.; Langendorff, M.; Ladner, H.-A.

doi:10.1007/bf00632063

Cited by 14 publications

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“…The period of maximum protection for 5HT (in our own experiments and those of Melching, Langendorff and Ladner 1958) was 5-10min after administration of 5HT, when only slight hypothermia is in evidence. However, it is cogent to draw attention to the relation of hypothermia to radioprotection in vivo in the case of 5HT.…”

Section: Discussionsupporting

confidence: 50%

“…However, it is cogent to draw attention to the relation of hypothermia to radioprotection in vivo in the case of 5HT. Langendorff et al (1958) have reported some potentiation of the protective action of cysteamine by reserpine, but it is doubtful if the potentiation shown is significant (p=0.3). Thirty minutes after injection, hypothermia is more marked, but protection is greatly reduced, which may explain Hope's results (Hope 1958).…”

Section: Discussionmentioning

confidence: 99%

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Studies of Mechanisms of Chemical Radiation Protection in Vivo

Brenk¹,

Haas²

1961

International Journal of Radiation Biology and Related Studies

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I. The radioprotective action of 5-hydroxytryptamine (5HT) in rats is specifically reversed by 5 HT antimetabolites and antagonists of the fl-haloalkylamine group, which block D receptors on smooth muscle cells. This reversal is not obtained with those antihistamines which have a very weak antiserotonin activity, despite their reversal of histamine protection.II. There is no correlation between the extractable 5HT in rat tissues, using bioassay techniques, and the radio-protection induced by exogenous administration of 5HT, by the anti-5HT-brominated lysergic acid (BOL) or by reserpine, singly or in combination.III. The sudden endogenous release of tissue 5HT gives radio-protection, but depletion of such endogenous 5HT by reserpine fails to alter radiosensitivity in vi,,o.IV. There is no correlation between hypothermia and radiosensitivity of rats, in respect to 5HT and reserpine.V. The precursor of 5I-IT in metabolism, 5-hydroxytryptophan as the L antipode, fails to afford protection against ionizing radiations quantitatively similar to 5HT; the slight protection which results is probably due to the formation of the amine in vivo following decarboxylation.VI. The results fail to support the protective action of 5HT in terms of either radical capture, or the formation of radio-resistant anaine-macromolecule complexes.VII. The results given favour a simple exposition of 5-hydroxytryptamine protection in terms of pharmacologically-induced tissue anoxia and a reduction in the 'oxygen effect'.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%