Zur Beeinflussung der Strahlenempfindlichkeit von Säugetieren durch chemische Substanzen

Cytofluorometric determination of protein‐bound thiols and DNA in cell nuclei

“…It is known that fast proliferating cells generally contain more sulfhy-dry1 groups than slowly proliferating cells (33) as well as the fact that the contents of PSH and PSS vary during the cell cycle (32). There is evidence that a number of substances containing SH-groups can increase the radioresistance of cells (28), whereas substances that covalently bind to SH-groups induce radiosensitization (35). As radiation-induced cell killing (reproductive cell death) is caused by radiation damage to the cell nucleus, likely the chromatin (l), radical scavanging by the nuclear SH-groups might be an important factor in radioprotection.…”