�ber den Stoffwechsel von 3-Amino-1,2,4-triazol in Ratten

Grunow, W.; Altmann, Hans; Böhme, Chr.

doi:10.1007/bf00353851

Cited by 9 publications

(2 citation statements)

References 33 publications

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“…The 1 hr time point may not have been optimal, but the results obtained illustrate the suitability of this method for analysis of AMT in human blood as a potential marker of exposure. AMT has been reported to be a metabolite of amitrol which was detected in the urine of rats [3]. Preliminary work on AMT spiked urine samples with the omission of the protein removal step indicate that this method could readily be adapted to determine AMT levels in urine samples.…”

Section: Resultsmentioning

confidence: 97%

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Determination of 3-amino-5-mercapto-1,2,4-triazole in serum

Depree

Siegel

2004

Journal of Chromatography B

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Section: Resultsmentioning

confidence: 97%

“…One study reported AMT to be a goitrogen, inhibiting thyroid peroxidase in rats [2]. AMT is also structurally related to, and is a metabolite of the herbicide amitrol (3-amino-1,2,4-triazole) [3]. Amitrol, a well-known goitrogen [4][5][6] exhibits potent antithyroid activity in rats [2].…”

Section: Introductionmentioning

confidence: 99%

Determination of 3-amino-5-mercapto-1,2,4-triazole in serum

Depree

Siegel

2004

Journal of Chromatography B

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Selected Aliphatic and Aromatic Nitrogen Compounds

Ziegler‐Skylakakis

2023

Patty's Toxicology

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This is an update of a previous chapter. It presents an evaluation of the toxicological potential of a number of aliphatic and aromatic nitrogen compounds, with information on their use, production, and exposure scenarios. These compounds were originally selected on the basis of their use in industry. In general, there has been little new information published in the literature that has significantly altered the previous profile of each compound. The three‐membered ring compounds discussed are ethyleneimine, propylenenimine, and triethylenemelamine. They are alkylating agents and have toxicological properties similar to nitrogen mustards. Six nitrogen mustards and their hydrochlorides are discussed as a group of chemicals. Furthermore, data on representatives of five‐membered ring nitrogen compounds (pyrrolidine, N ‐methyl‐2‐pyrrolidone) and of six‐membered ring compounds (piperidine, piperazine, morpholine, and hexamethylenetetramine) are included. Captan, captafol, and folpet—three N ‐sulfenyl phthalimide fungicides—and benomyl, carbendazim, and thiophanate‐methyl—benzimidazole fungicides—are evaluated as separate groups. Data on 1‐ H ‐benzotriazol are also included in this chapter. The subchapter of each compound or group of compounds includes the physical and chemical properties, information as to use and production, data on the toxicological potential, and standards, regulations, or guidelines of exposure. In addition, data on the environmental impact of each compound or group of compounds are presented and evaluated.

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Aliphatic and Aromatic Nitrogen Compounds

Trochimowicz¹,

Kennedy²,

Krivanek³

2001

Patty's Toxicology

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This chapter covers both aliphatic and aromatic compounds that contain one or more nitrogen atoms in their structures. Only a small number of the nitrogen‐containing compounds that could be considered will be reviewed here based mainly on their uses in industry. Three‐membered rings discussed are ethyleneimine, propyleneimine, and one polyfunctional derivative, triethylenemelamine. Toxicologists, chemists, and biologists have always been interested in ethylenimine and its derivatives because they are reactive, are useful at relatively low doses, and are moderately to highly toxic. Ethylenimines are classic alkylating agents and have toxicological effects similar to nitrogen mustards. Monofunctional derivatives of ethylenimine are less potent in producing the characteristic toxicity of the group than the derivatives that have two or more ethylenimine groups. Finally, polymers of ethylenimine and its derivatives have shown a relatively low order of toxicity. Six simple nitrogen mustards (β‐chloroethylamines) are also covered in this chapter. They are all tertiary amines in which the halogen atom and the amine portion have reactivities similar to the alkyl halides and alkyl amines. They have no significant industrial uses in the United States, but they are used in medicine as “antineoplastic agents” and in treating some nonmalignant diseases. Representative nitrogen‐containing chemicals that have five‐membered rings (pyrrolidine, NMP) and six‐membered rings (piperidine, piperazine, morpholine, and HMTA) are also discussed in this chapter in some detail.

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�ber den Stoffwechsel von 3-Amino-1,2,4-triazol in Ratten

Cited by 9 publications

References 33 publications

Determination of 3-amino-5-mercapto-1,2,4-triazole in serum

Determination of 3-amino-5-mercapto-1,2,4-triazole in serum

Selected Aliphatic and Aromatic Nitrogen Compounds

Aliphatic and Aromatic Nitrogen Compounds

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