Benzothiazole applications as fluorescent probes for analyte detection

Near-Infrared Probes for Biothiols (Cysteine, Homocysteine, and Glutathione): A Comprehensive Review

“…Along with excellent biological properties, the benzothiazole moiety is also known for its photophysical properties, especially high fluorescence quantum yields and high stability in different solvents. Therefore, benzothiazole-based compounds have been used for applications in sensing, supramolecular chemistry, material chemistry, etc. − …”

Highly sensitive benzothiazole-based chemosensors for detection and bioimaging of peroxynitrite in living cells

“…Inspired by the previous works, two simple benzothiazole-based fluorescent probes, BS1 and BS2, for the detection and imaging of ONOO − in vitro and vivo were designed for that benzothiazole probes share the merits of high quantum yield and large Stokes shift. 48 And the two probes were easily obtained based on the condensation reaction of 2-aminothiophenol and aromatic aldehydes in the presence of catalytic amount of lanthanum( iii ) nitrate hexahydrate in a considerable yield under mild conditions. 49 The difference of the probes in structure is that BS1 possesses a reactive electron withdrawing diphenyl phosphonate unit while BS2 bears a pinacol boronic ester group for monitoring ONOO − .…”

Development of Brain-Tumor-Targeted Benzothiazole-Based Boron Complex for Boron Neutron Capture Therapy

“…7 Benzothiazole, a heterocyclic compound, has been widely used as a scaffold in several theranostic agents for brain diseases (e.g., Alzheimer's disease and brain tumors) owing to its high brain permeability and antitumor effects 11 and its good optical properties. 12 We previously reported that Gd-DO3Abenzothiazole (Gd-DO3A-BTA) exhibited antiproliferative activity while showing an MRI contrast effect by targeting tumors. 13 Thereafter, it was applied to gadolinium neutron capture therapy (Gd-NCT) to demonstrate the therapeutic effect on tumors in vivo, but there was a limit to its application in brain diseases due to its low BBB permeability.…”

“…Benzothiazole, a heterocyclic compound, has been widely used as a scaffold in several theranostic agents for brain diseases (e.g., Alzheimer’s disease and brain tumors) owing to its high brain permeability and antitumor effects and its good optical properties . We previously reported that Gd-DO3A-benzothiazole (Gd-DO3A-BTA) exhibited antiproliferative activity while showing an MRI contrast effect by targeting tumors .…”

“…This indicates that the brain uptake of L-BPA is a result of active, not passive, transport of LAT-1 . Benzothiazole derivatives are known to penetrate the BBB and enter tumor cells through the aryl hydrocarbon receptor (AHR), which is expressed in the tumors. ,, However, even considering passive transport, except for active transport through receptors, BTPB showed very high BBB permeability. This resulted in high brain uptake in a biodistribution experiment, which is thought to be the effect of both passive and active transport through receptors in vivo .…”