Benzodiazepine receptor and serotonin 2A receptor modulate the aversive-like effects of nitric oxide in the dorsolateral periaqueductal gray of rats

Abstract

The results suggest that the aversive-like effects of NO donor in the dlPAG may be modulated by the BZ and 5-HT(2A/2C) receptors.

Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters

“…The effects of 5-HT on flight responses induced by SIN-1 may involve indirect GABAergic facilitation, since 5-HT 2 receptors are co-expressed in GABAergic neurons (8). In agreement with these results, defensive-like responses induced by intra-dlPAG administration of SIN-1 were attenuated by midazolam, a benzodiazepine receptor agonist (47). …”

Role of glutamate NMDA receptors and nitric oxide located within the periaqueductal gray on defensive behaviors in mice confronted by predator

“…For instance, a number of studies have shown that NO enhancement can also occur following other glutamatergic receptor subtypes activation such as AMPA, kainate, and metabotropic receptors (Southam et al 1991;Okada 1992). Furthermore, it has been suggested that a set of neurotransmitters including serotonin, bradykinin, endothelin, acetylcholine, noradrenaline and GABA might be involved in the nitric oxide modulation (Reiser 1990a, b;Lovick et al 2000;Moreira and Guimarães 2004). In this context, there are evidences emphasizing that NO production following NMDA receptor activation plays a role over some neurotransmitters release such as serotonin and dopamine in different brain regions (e.g., hippocampus and striatum; Whitton et al 1994;Wegener et al 2000).…”

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

“…Corroborating this finding, neuroimaging studies show increased DPAG activity in panic patients (Del-Ben et al, 2009) or in healthy volunteers exposed to a proximal threatening stimulus such as predator exposure (Mobbs et al, 2007). Panic-like responses can be modulated by several neurotransmitters including serotonin, GABA, glutamate and nitric oxide (Moreira and Guimaraies, 2004). …”